Navigation Links
A new mechanism that contributes to the evolution of cancer
Date:1/31/2013

Cancer arises from the accumulation of mutations and structural changes in chromosomes, which in some cases give rise to combinations that favour the growth or expansion of the disease. In this context, chromosomes tend to lose or duplicate entire regions, although, the mechanisms that initiate these chromosomal abnormalities are not fully understood.

A study published this week in the journal Cell, in which researchers from the Spanish National Cancer Research Centre (CNIO) participated, demonstrates a new mechanism that explains how these changes originate in the chromosomes of tumour cells.

The work, led by André Nussenzweig's group at the National Cancer Institute (NCI, USA), with the participation of CNIO researcher Óscar Fernández‐Capetillo, shows that collisions between the machinery responsible for duplicating the DNA and for transferring this genomic information to the RNA for protein synthesisa phenomenon known as transcriptionare the cause of a very high proportion of the chromosomal alterations found in tumours.

Until now, it was believed that the majority of these problems originated in areas of the genome that were difficult to duplicate and which, therefore, required the completion of the entire S phase of the cell cycle; a stage in which cells duplicate their DNA. Due to this episode, these regions were especially exposed to breaks or aberrations.

The current study reveals that other areas of the genome also existthose that replicate quickly early in S phasethat are prone to breakages. In particular, the researchers demonstrate that this occurs when these DNA regions that replicate, have surrounding genes that are being actively copied to RNA.

"In these cases, the collision between the two machineries, the duplication machine and the transcription machine, can be responsible for generating chromosomal alterations that are deadly for cells," says Fernández‐Cap
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
2. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
3. Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children
4. Scientists discover mechanism that could reduce obesity
5. New mechanism for cancer progression discovered by UNC and Harvard researchers
6. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
7. Mechanism of breathing muscle paralysis in dreaming sleep identified
8. New mechanism of action for PARP inhibitors discovered
9. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
10. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
11. Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... 26, 2015 Surging to over 674,923 ... the leading online health and wellness sites, Consumer Health ... online community. It has proven to be a ... articles, watch videos, ask questions and interact with the ... the official Consumer Health Digest YouTube Channel has offered ...
(Date:5/26/2015)... Abington is pleased to announce ... practice with seven medical professionals, has joined Abington ... site in the United States to be recognized ... the National Committee for Quality Assurance. , Family ... sick care – including routine gynecology care and ...
(Date:5/26/2015)... (PRWEB) May 26, 2015 3,000 senior ... to explore and debate the future of the connected ... Freer Logic’s steering wheel that can read a driver’s ... to control a driving simulator by mind alone just ... of Freer Logic said: “We are working on cognitive ...
(Date:5/26/2015)... CO (PRWEB) May 26, 2015 It ... diverse community foundation in Colorado. On Wednesday, May 13, ... ushered in a new era of community-based giving with ... Titled “Our Future in the Making,” the event celebrated ... The Denver Foundation to mobilize resources for good. , ...
(Date:5/26/2015)... 26, 2015 On May 26, 2015, My ... salesman and distributor Dwayne Windfall. At the start of the ... that has some unique characteristics with it, so could you ... Windfall replies saying, “I was reading the newspaper looking for ... they were looking for a person with hustle. I responded ...
Breaking Medicine News(10 mins):Health News:Consumer Health Digest Official YouTube Channel: A Reliable Source of Health Information 2Health News:Family Medicine, Geriatrics and Wellness Joins Abington Health Physicians 2Health News:The World’s Biggest Connected Car Exhibition is Back in Detroit 2Health News:The World’s Biggest Connected Car Exhibition is Back in Detroit 3Health News:Celebrating "Our Future in the Making" 2Health News:Celebrating "Our Future in the Making" 3Health News:My Positive Perspective Broadcasts Episode with Oceans 6 to Discuss Their Role in Helping the Community 2
... TUESDAY, May 22 (HealthDay News) -- Healthier lifestyles and better ... for Americans with diabetes between 1997 and 2006, especially ... government report shows. During that time, deaths from all ... deaths caused by heart disease and stroke in this group ...
... YORK (May 22, 2012) -- Up to half of all prostate ... "fusion" gene and formation of its unique protein -- but no ... Cornell Medical College researchers have found that in these cancer cells, ... known as a chromatin, is warped in such a way that ...
... MTV programs about teenage pregnancy -- "16 and Pregnant" and ... the shows glamorized teenage pregnancy, while supporters said they discouraged ... suggests they,re both right. The study, which will appear ... female students because of the high dropout rate associated with ...
... It,s quite common for a female song sparrow to stray ... door, but a new study shows that sleeping around can ... The American Naturalist, found that offspring conceived outside ... than within-pair offspring. The findings throw a monkey wrench into ...
... (HealthDay News) -- Colonoscopies helped doctors detect a high ... the screening for the first time, a new study ... made available to otherwise healthy elderly people who have ... Grand Rapids Medical Education Partners, and colleagues from Spectrum ...
... of Environmental Health Sciences (NIEHS), part of the National ... Research Program (SRP) at the University of California, San ... grant will fund continued research on the molecular and ... and other hazardous waste sites. It is the ...
Cached Medicine News:Health News:U.S. Sees Drop in Deaths Linked to Diabetes 2Health News:U.S. Sees Drop in Deaths Linked to Diabetes 3Health News:Scientists unravel role of fusion gene in prostate cancer 2Health News:Scientists unravel role of fusion gene in prostate cancer 3Health News:Scientists unravel role of fusion gene in prostate cancer 4Health News:Viewers' family background affects how they react to MTV shows 16 and Pregnant, Teen Mom 2Health News:Viewers' family background affects how they react to MTV shows 16 and Pregnant, Teen Mom 3Health News:For monogamous sparrows, it doesn't pay to stray (but they do it anyway) 2Health News:Colonoscopy May Detect Curable Cancer in Elderly: Study 2Health News:UC San Diego Superfund Research Program receives $15 million grant renewal 2
(Date:5/26/2015)... May 26, 2015  Organovo Holdings, Inc. (NYSE MKT: ... breakthrough 3D bioprinting technology, announced today that the company ... 2015 Healthcare Conference, to be held in ... Keith Murphy , Chairman and Chief Executive Officer, ... advances and partnerships. Details of the presentations ...
(Date:5/26/2015)... May 26, 2015  RXi Pharmaceuticals Corporation ... focused on discovering and developing innovative therapies ... ophthalmology, today announced that the Company,s President and ... present at the Jefferies 2015 Global Healthcare ... 11:30 a.m. EDT. Dr. Cauwenbergh will present ...
(Date:5/26/2015)... May 26, 2015 For the ... Quality of Life Throughout Europe, the Middle ... Astellas Pharma EMEA is celebrating its 10 ... through the historic merger of Japanese pharmaceutical companies Yamanouchi ... committed to turning science into value for patients through ...
Breaking Medicine Technology:Organovo Holdings, Inc. To Present at Jeffries 2015 Healthcare Conference 2Organovo Holdings, Inc. To Present at Jeffries 2015 Healthcare Conference 3RXi Pharmaceuticals to Present at the Jefferies 2015 Global Healthcare Conference 2RXi Pharmaceuticals to Present at the Jefferies 2015 Global Healthcare Conference 3RXi Pharmaceuticals to Present at the Jefferies 2015 Global Healthcare Conference 4Astellas Pharma EMEA Celebrates Its 10th Anniversary 2Astellas Pharma EMEA Celebrates Its 10th Anniversary 3Astellas Pharma EMEA Celebrates Its 10th Anniversary 4
... symptoms of ADHD, DURHAM, N.C., Sept. 10 ... stress has been shown to significantly reduce,symptoms of ... phase 3 clinical trial conducted by Addrenex,Pharmaceuticals., ... achieved statistically,significant improvement over placebo in reducing an ...
... combination of micronutrients superior to, current ,AREDS, standard ... -, HOUSTON, Sept. 10 A landmark ... a patented,combination of antioxidants and micronutrients, enabled patients ... in the study,s,placebo arm, who received the "AREDS-type" ...
Cached Medicine Technology:Addrenex Pharmaceuticals Announces Positive Phase III Clinical Results for Clonicel to Treat ADHD 2Addrenex Pharmaceuticals Announces Positive Phase III Clinical Results for Clonicel to Treat ADHD 3TOZAL(R) Nutritional Supplement Improves Vision in Common Form of Macular Degeneration 2TOZAL(R) Nutritional Supplement Improves Vision in Common Form of Macular Degeneration 3
10 L, Bulk Recommended for 2, 5 and 10 L pipettes....
10 L, Bulk Recommended for 2, 5, 10 L pipettes....
... Theken eDISC is a revolutionary advancement in ... assess and manage their patients. The eDISC's ... the eDISC from 1st and 2nd generation ... loads of the lumbar spine, the eDISC ...
... Resistant Tips offer a safe alternative to ... designed for applications such as PCR(a), pipetting ... ART Tips are excellent for tissue culture, ... ART Tips prevent aerosol contaminants and liquids ...
Medicine Products: