Navigation Links
A new mechanism that contributes to the evolution of cancer
Date:1/31/2013

Cancer arises from the accumulation of mutations and structural changes in chromosomes, which in some cases give rise to combinations that favour the growth or expansion of the disease. In this context, chromosomes tend to lose or duplicate entire regions, although, the mechanisms that initiate these chromosomal abnormalities are not fully understood.

A study published this week in the journal Cell, in which researchers from the Spanish National Cancer Research Centre (CNIO) participated, demonstrates a new mechanism that explains how these changes originate in the chromosomes of tumour cells.

The work, led by André Nussenzweig's group at the National Cancer Institute (NCI, USA), with the participation of CNIO researcher Óscar Fernández‐Capetillo, shows that collisions between the machinery responsible for duplicating the DNA and for transferring this genomic information to the RNA for protein synthesisa phenomenon known as transcriptionare the cause of a very high proportion of the chromosomal alterations found in tumours.

Until now, it was believed that the majority of these problems originated in areas of the genome that were difficult to duplicate and which, therefore, required the completion of the entire S phase of the cell cycle; a stage in which cells duplicate their DNA. Due to this episode, these regions were especially exposed to breaks or aberrations.

The current study reveals that other areas of the genome also existthose that replicate quickly early in S phasethat are prone to breakages. In particular, the researchers demonstrate that this occurs when these DNA regions that replicate, have surrounding genes that are being actively copied to RNA.

"In these cases, the collision between the two machineries, the duplication machine and the transcription machine, can be responsible for generating chromosomal alterations that are deadly for cells," says Fernández‐Capetillo.

This study moves us a step closer to understanding the mechanisms that explain the chromosomal alterations in tumour cells most common in tumours. "This new mechanism can even explain up to 50% of the abnormalities associated with some types of leukaemia," says Fernández‐Capetillo.

Furthermore, this work defines a new class of genomic fragile sites that might contribute to our understanding of the changes that took place in the genome throughout evolution.


'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
2. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
3. Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children
4. Scientists discover mechanism that could reduce obesity
5. New mechanism for cancer progression discovered by UNC and Harvard researchers
6. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
7. Mechanism of breathing muscle paralysis in dreaming sleep identified
8. New mechanism of action for PARP inhibitors discovered
9. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
10. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
11. Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... MD (PRWEB) , ... October 12, 2017 , ... The ... of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual ... – 8. , In honor of Morris F. Collen, a pioneer in the field ...
(Date:10/12/2017)... ANGELES (PRWEB) , ... October 12, 2017 , ... ... Parsa Mohebi Hair Restoration, has recently contributed a medical article to the newly ... on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
(Date:10/12/2017)... FL (PRWEB) , ... October 12, 2017 , ... On ... holding a treadmill relay – Miles by Moonlight to raise money for the American ... $300 or more. , Teams will work together to keep their treadmills moving ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
(Date:9/12/2017)... FRANCISCO , Sept. 12, 2017  ValGenesis ... Management Solutions (VLMS), is pleased to announce the ... a member of its Board of Directors and ... ValGenesis VLMS enables life science companies to manage ... the use of paper in this process. Furthermore, ...
Breaking Medicine Technology: