Navigation Links
A new mechanism for reversible proteasome inhibition
Date:12/13/2010

What makes cancer cells so dangerous is that they grow in an unregulated way and proliferate much faster than other cells. The proteasome, a large protein complex, plays a key role in this process: By breaking down used proteins for recycling, it clears the way for the next cycle. New hope was spawned several years ago with the discovery that inhibiting proteasomes can be used as a means to put the brakes on cell growth. In the mean time, the first drug using this approach, Bortezomib, generates revenues in excess of one billion U.S. dollars per year. However, it also inhibits other important proteins and thus sets off a host of severe side effects. Hence, there is a worldwide search for alternatives.

A variant of the proteasome, the immuno-proteasome, is a leading actor in another vital process: the immune reaction. The production of human insulin in genetically modified bacteria is a boon for diabetes patients. But calculating required doses and injecting insulin on a daily basis is a considerable burden. The transplantation of intact insulin-producing islet cells from pigs could be a solution, but the immune reaction stands in the way. If physicians were able to curb the immuno-proteasome temporarily, they could possibly get the rejection reaction under control.

In both cases, targeting the intervention as specifically as possible is essential to minimizing the damage caused by side effects. Besides Bortezomib two other proteasome inhibitors Carfilzomib and Salinosporamide A, derived from a poison produced by a marine bacterium are already in the human clinical trial stage. In earlier research, Professor Groll's team succeeded in explaining the mechanism of action of both substances. They follow the same principle, which is considerably more specific than Bortezomib in binding at the desired location in the proteasome and thus produce significantly fewer side effects. Yet, when they take effect, they destroy the proteasomes irreversibly
'/>"/>

Contact: Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. IU research team discovers TB disease mechanism and molecule to block it
2. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
3. Tumor mechanism identified
4. Multiple sclerosis, Italian researchers discover a possible onset mechanism for the disease
5. Pancreatic Cancer Study Reveals Mechanism Initiating Disease, In Mice
6. Pancreatic cancer study reveals mechanism initiating disease, in mice
7. Study identifies 1 of the mechanisms behind breast cancer metastasis
8. Mechanism that may trigger degenerative disease identified
9. A key mechanism links virgin olive oil to protection against breast cancer
10. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
11. Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new mechanism for reversible proteasome inhibition
(Date:12/19/2014)... 2014 After a 13-year absence from ... returning to the stage to entertain his many worldwide ... performances, and the successful tour has been steadily expanding ... , Visit Ticketability.com for a large inventory ... at fair prices. , Music fans have had a ...
(Date:12/19/2014)... The Hermitage Club at Haystack ... Vermont’s Deerfield Valley, announced today that it has unveiled ... songs. , Three time Grammy Award Winner Kenny ... followed by a trail naming ceremony. Hermitage Club Founder, ... “I’m Alright” the theme song for the movie soundtrack ...
(Date:12/19/2014)... News) -- The tragic death from "rat-bite fever" of a ... pet rodents, according to a report from the U.S. Centers ... rare but potentially fatal illness that should be considered in ... history of rodent exposure is reported," said a team led ... The case outlined in the report occurred in August ...
(Date:12/19/2014)... (HealthDay News) -- Traveling through the same U.S. airport ... three others within a four-hour time span, illustrating just ... shows. "The exposures in this report were not ... international terminal, highlighting the fact that measles is highly ... infectious disease specialist at the U.S. Centers for Disease ...
(Date:12/17/2014)... While countless companies tempt patients to buy hCG ... of their purchase. Not only is the sale of hCG ... patients who buy hCG online are typically receiving products that ... real hCG present. Illegal internet hCG is typically manufactured outside ... and may contain unknown fillers that can pose very serious ...
Breaking Medicine News(10 mins):Health News:Garth Brooks Tickets for Joe Louis Arena: Ticketability.com Becomes a Popular Destination for Discount Tickets for Garth Brooks’ Detroit Concerts Set for February 27-28 2Health News:The Hermitage Club Officially Names Four Ski Trails after Iconic Rock Songs by Grammy Award Winner Kenny Loggins 2Health News:Scratch From Pet Rat Kills Child; CDC Warns of Risk 2Health News:Arriving Now at Gate 42: Measles 2Health News:Arriving Now at Gate 42: Measles 3Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 2Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 3
... CardioGenics Holdings Inc. (OTC Bulletin Board: JAGH) has received ... for the Company on the OTCBB will take place at ... The new ticker symbol for "CardioGenics Holdings Inc." on the ... name and ticker symbol change that is scheduled to take ...
... (Nasdaq: AKRX ) will release third quarter 2009 earnings Tuesday, November 10, before the market ... results followed by a Q&A session: , , Subject: ... Date/Time: ... ...
... waists in men spell trouble, study finds , MONDAY, Oct. ... appears to affect the risk of dangerous blood clots in ... new Danish study indicates. , The 10-year study found that ... thromboembolism (VTE) in women but not men, while a wider ...
... Some simple precautions will safeguard young trick-or-treaters, experts say ... trick to keeping children and the rest of the ... that the night is a treat for everyone. , ... tips: , Choose costumes that are bright and ...
... BOSTON, Oct. 26 Uno Chicago Grill®, America,s Healthiest Chain ... limited-time-only fall menu. , This exciting fall menu ... cranberries are a well-known and popular accent to many dishes, ... once the territory of a select few health food aficionados. ...
... , CENTENNIAL, Colo., Oct. 26 LABS Inc., one ... the country, announced today that it will begin offering ... transfusion medicine and blood services industry. LABS Inc.,s acquisition ... expertise to blood collection programs nationwide. , LABS Inc. ...
Cached Medicine News:Health News:Where You Put on Pounds May Influence Clot Risk 2Health News:Treat Kids to a Safe Halloween 2Health News:Go, Go, Goji! UNO(R) Fall Menu Is 'Berry' Delicious 2Health News:Go, Go, Goji! UNO(R) Fall Menu Is 'Berry' Delicious 3Health News:LABS Inc. to Offer Donor Testing Services for Transfusion Medicine and Blood Services Industry 2
(Date:12/19/2014)... WASHINGTON , Dec. 18, 2014 Since ... Road, the site now known as the leading online ... has seen explosive growth in its offering of drugs ... Citizens Alliance show the takedowns did succeed in lowering ... our last review of the markets in August. But ...
(Date:12/19/2014)... China separating membrane market has witnessed robust development ... years, albeit as a later starter. In 2012, the size ... approximated RMB12 billion, with the proportion worldwide soaring to 16.3%. ... membrane market will continue its growth rate by around 20% ... will jump to roughly RMB25 billion. An integrated ...
(Date:12/17/2014)... , December 17, 2014 Revenue and ... expenditure on research and development In the past ... revenue by two percent to EUR 4.287 billion (last year: ... by 14 percent to EUR 360 million. "Overall, 2013/14 was ... Michael Kaschke , President and CEO of Carl Zeiss ...
Breaking Medicine Technology:Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3ZEISS Asserts its Position in Difficult Environment 2
9" X 14" Translucent plastic may be used with illuminated test cabinets or as a wall chart 20/100 to 20/10....
Wilbrandt-binkhorst irrigating cannula....
McIntyre-Binkhorst Cannula have a smooth blunt tip end opening....
Wire lid retractor may be clamped to surgical drape with suture or elastic band. Large pair....
Medicine Products: