Navigation Links
A new light on the anti-tumor mechanisms of Scutellaria barbata
Date:12/31/2008

Medicinal plants have been used as traditional remedies for hundreds of years. Among them, S. barbata has been traditionally used in treatment of hepatitis, inflammation, osteomyelitis and gynecological diseases in China. Studies indicate that extracts from S. barbata have growth inhibitory effects on a number of human cancers. Reports are available on the treatment of lung, breast and digestive system cancer, hepatoma, and chorioepithelioma with S. barbata extracts. However, the underlying mechanism of the antitumor activity of S. barbata extracts remains unclear.

A research article to be published on December 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Zhi-Jun Dai from the Medical School of Xi'an Jiaotong University studied the growth inhibitory effects of S. barbata and determined its mechanism of antitumor activity in mouse liver cancer cell line H22.

They found that ESB could inhibit the proliferation of H22 cell in a time dependent manner. Among the various phases of cell cycle, the percentage of cells in S phase was significantly decreased, while the percentage of cells in G1 phase was increased. Flow cytometry assay also showed ESB had positive effect on apoptosis. Typical apoptotic morphology such as condensation and fragmentation of nuclei and blebbing membrane of the apoptotic cells could be observed through transmission electron microscope and fluorescence microscope. Further investigating the molecular mechanism behind ESB-induced apoptosis, cells treated with ESB underwent a rapid loss of mitochondrial transmembrane potential(delta psi m), release of mitochondrial cytochrome c into cytosol, induction of caspase-3 activity in a dose-dependent manner. This may offer new evidence for S. barbata in the treatment of hepatoma in clinical practice.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. A new light on tumor immunotherapy for gastric cancer
2. Guardian Life Flight, Air Ambulance Service Provider, Announces Addition of Sam Kini, M.D. To Its Team
3. Annual Congress European Association of Urology: highlights in Stockholm
4. Festival of Lights Holiday Celebration
5. Easter Seals Study Sheds New Light on Parents Life-Long Fears, Anxieties and Critical Supports Needed to Raise a Child With Autism
6. Electronic Sports Launches Dogfight Fitness Flight Simulator: The Next Generation of Exergaming
7. U.S. Supreme Court Ruling Allowing Light Cigarette Lawsuits Is Victory for Consumers and Health
8. New Report to Highlight Need for Public Health Insurance Plan Outlined in Obamas Proposals
9. Narrow-band imaging comparable to white light colonoscopy in differentiating colorectal polyps
10. Light shines for potential early cancer diagnosis technique
11. Sinobiopharma Reports Highlights of Third Quarter Results for Its Operating Subsidiary, Dong Ying China
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... Spectrum Aquatics has launched a brand new ... designed and built with the user in mind. , “Over the last two years ... that an ADA 400 lbs lift is a necessary requirement for certain facilities with ...
(Date:5/31/2016)... ... , ... In a recent interview on The Greenburgh Report radio show hosted ... WVOX (1460 AM), leading medical insurance advocate Adria Goldman Gross discussed several eye-opening ... maelstrom.” , During the interview with Mr. Feiner that aired on May 7, ...
(Date:5/31/2016)... , ... May 31, 2016 , ... ... media enterprise focused on patients with cancer, has added Cancer and Careers ... website visitors with more timely content on continuing successful careers while fighting cancer. ...
(Date:5/30/2016)... ... May 30, 2016 , ... Shaolin Institute ... 8-day-8 and 8-night special intensive summer training camp starts on June 17th on ... offers families and children a fun and unique experience with an opportunity to ...
(Date:5/28/2016)... ... May 28, 2016 , ... SuperCloset is proud to officially launch our ... day issues, struggles and obstacles veterans’ need to overcome in order to face their ... or retired military veteran(s) with a donated SuperCloset product based on the needs and ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 According to market research ... and Demand Forecast to 2022 - Industry Insights by ... published by P&S Market Research, the global insulin delivery ... and it is expected to grow at a CAGR ... pump segment is expected to witness the fastest growth ...
(Date:5/25/2016)... 2016  Granger Diagnostics today announced immediate availability of ... infections. This test ensures discovery of ALL bacteria, ... test requires only a simple swab of the wound ... G. Bostwick , MD, Chief Medical Officer, described ... "We are excited to make available, for the ...
(Date:5/25/2016)... 2016 MedDay, a biotechnology company focused ... oral presentation entitled "High doses of biotin in progressive multiple ... given by Professor Ayman Tourbah , Principal Investigator of ... European Academy of Neurology (EAN) in Copenhagen, Denmark ... will take place on Sunday, 29 May 2016 from 14:45 ...
Breaking Medicine Technology: