Navigation Links
A new light on the anti-tumor mechanisms of Scutellaria barbata
Date:12/31/2008

Medicinal plants have been used as traditional remedies for hundreds of years. Among them, S. barbata has been traditionally used in treatment of hepatitis, inflammation, osteomyelitis and gynecological diseases in China. Studies indicate that extracts from S. barbata have growth inhibitory effects on a number of human cancers. Reports are available on the treatment of lung, breast and digestive system cancer, hepatoma, and chorioepithelioma with S. barbata extracts. However, the underlying mechanism of the antitumor activity of S. barbata extracts remains unclear.

A research article to be published on December 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Zhi-Jun Dai from the Medical School of Xi'an Jiaotong University studied the growth inhibitory effects of S. barbata and determined its mechanism of antitumor activity in mouse liver cancer cell line H22.

They found that ESB could inhibit the proliferation of H22 cell in a time dependent manner. Among the various phases of cell cycle, the percentage of cells in S phase was significantly decreased, while the percentage of cells in G1 phase was increased. Flow cytometry assay also showed ESB had positive effect on apoptosis. Typical apoptotic morphology such as condensation and fragmentation of nuclei and blebbing membrane of the apoptotic cells could be observed through transmission electron microscope and fluorescence microscope. Further investigating the molecular mechanism behind ESB-induced apoptosis, cells treated with ESB underwent a rapid loss of mitochondrial transmembrane potential(delta psi m), release of mitochondrial cytochrome c into cytosol, induction of caspase-3 activity in a dose-dependent manner. This may offer new evidence for S. barbata in the treatment of hepatoma in clinical practice.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. A new light on tumor immunotherapy for gastric cancer
2. Guardian Life Flight, Air Ambulance Service Provider, Announces Addition of Sam Kini, M.D. To Its Team
3. Annual Congress European Association of Urology: highlights in Stockholm
4. Festival of Lights Holiday Celebration
5. Easter Seals Study Sheds New Light on Parents Life-Long Fears, Anxieties and Critical Supports Needed to Raise a Child With Autism
6. Electronic Sports Launches Dogfight Fitness Flight Simulator: The Next Generation of Exergaming
7. U.S. Supreme Court Ruling Allowing Light Cigarette Lawsuits Is Victory for Consumers and Health
8. New Report to Highlight Need for Public Health Insurance Plan Outlined in Obamas Proposals
9. Narrow-band imaging comparable to white light colonoscopy in differentiating colorectal polyps
10. Light shines for potential early cancer diagnosis technique
11. Sinobiopharma Reports Highlights of Third Quarter Results for Its Operating Subsidiary, Dong Ying China
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... , ... “Congratulations! It's A Boy! God’s Gift: A Story of Love”: a ... “Congratulations! It's A Boy! God’s Gift: A Story of Love” is the creation of ... , Published by Christian Faith Publishing, Dale Anthony and Rachael Anthony’s new book is ...
(Date:8/18/2017)... VA (PRWEB) , ... August 18, 2017 , ... More ... the Democratic Republic of Congo (DRC) thanks to an ambitious venture that conjoined the ... well as the generous support of the Liberty community. These shoes will save lives ...
(Date:8/18/2017)... , ... August 18, 2017 ... ... Quick International, LLC (“Quick”), a highly specialized asset-light logistics provider of complex ... into a definitive agreement to purchase Unitrans International Corporation, a division of ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... this summer’s edition of “Vision & Hearing,” advocating for active, healthy lifestyles and ... on resources available for individuals with hearing impairments and shares the latest innovations ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... liquid handling handheld devices. Through an educational webinar, they will present the line ... a chance to learn how easy you can automate everyday pipetting tasks. , ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Aug. 7, 2017  Endo International plc (NASDAQ: ... to resolve virtually all known U.S. mesh product liability ... resolve the known remaining U.S. claims at reasonable values. ... in the fourth quarter of 2017 and continuing through ... second quarter 2017 results, the Company intends to increase ...
(Date:8/3/2017)... SAN DIEGO , Aug. 3, 2017  Opioid ... crippling diseases driving up healthcare costs and threatening outcomes, ... the lab supply and IVD industry that support them, ... health care market researcher said that drugs of abuse, ... vendors and sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... Flight Network and PeaceHealth Oregon Network announced they renewed a ... efficiency for patients at hospitals in Eugene ... , and Florence, Oregon , who ... work collaboratively to move patients who require the highest level ... emergency exists. PeaceHealth ...
Breaking Medicine Technology: