Navigation Links
A new key to detecting deadly aortic aneurysms

New Haven, Conn.Yale scientists have discovered a way to use a simple blood test that may accurately detect thoracic aneurysm disease (TAA), which gives little warning and is almost always fatal if untreated.

The study, published this month in Public Library of Science (PLoS), represents the collaborative work of Yale School of Medicine, Applied Biosystems, and Celera Diagnostics.

TAAs occur in the part of the aorta that passes through the chest. They can become huge without causing symptoms. In fact, only one in 20 patients has symptoms before internal rupture occursmaking advance detection key to treatment. Once the aneurysm ruptures, a person can go into shock and die from internal bleeding. Currently detection of these aneurysms is made by relatively expensive tests such as a chest X-ray or CT scantypically when a patient is being evaluated for other conditions.

A standardized blood-based test capable of detecting individuals at risk for aneurysm disease would represent a major advance in clinical care, said John Elefteriades, M.D., section chief of cardiothoracic surgery. This study indicates we may be able to develop such a test.

In this study Elefteriades and his colleagues took blood samples from 58 persons diagnosed with TAA disease and 36 spouses who did not have the disease. Using a gene expression profiling technology, they identified a 41-gene signature in blood cells that distinguishes TAA patients from those without the disease. The gene expression signature and the prediction model were identified using a complete workflow of instruments, reagents, and software from Applied Biosystems. These signature genes were further validated using TaqMan real-time PCR assays. The accuracy rate in various analyses is 78 percent to 85 percent.

It has become increasingly evident that the immune system plays a pivotal role in the development of aortic aneurysms, Elefteriades said. We thus hypothesized that gene expression patterns in peripheral blood cells may reflect TAA disease status.

The next step, which the researchers say is underway, is validation in real-time clinical studies. The investigative team is also interested in determining if abdominal aneurysms share a similar RNA signature, and if the RNA can predict rupture or dissection of an aneurysm.


Contact: Jacqueline Weaver
Yale University

Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Detecting anomalies in heart rythm
3. Detecting brain aneurysms
4. New device for detecting artery blockages
5. Detecting Colorectal Cancer
6. Associated scan for detecting ovarian cancer spread
7. Photographs An Effective Tool In Detecting Skin Cancer
8. Mammograms The Best In Detecting Breast Cancer
9. Detecting Lung Cancer Early
10. Detecting Lung Cancer In Its Initial Stages
11. A New Way Of Detecting Osteoporosis
Post Your Comments:
(Date:11/30/2015)... , ... November 30, 2015 , ... ... continuing education course in Dallas, TX, on January 29 and 30, 2016. The ... improve the functions of their practices, to learn how to better succeed in ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... a key disease-causing component of bacteria could be effective in fighting methicillin-resistant Staphylococcus ... Georgia State University. , Their study showed that small molecule analogs that target ...
(Date:11/30/2015)... ... November 30, 2015 , ... Dr. Seth D. Margulies ... locations, patients can visit Dr. Margulies to experience the best available orthodontic experience in ... title of "NJ Top Dentist"! , Orthodontics is the branch of dentistry that specializes ...
(Date:11/30/2015)... ... 2015 , ... ”Dying Words: The AIDS Reporting of Jeff Schmalz and How ... coincide with World AIDS Day. The multi-media project will be in audio documentary form ... he was dying of the disease. , A collaborative effort led by author, professor ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... Reports magazine, quoted Michael Hansen, Ph.D., a senior scientist at Consumer Reports as ... more so for a child’s exposure limits. , The original Nov 2015 CR ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... KONG, Nov. 30, 2015 (HK$,000)For the Six Months Ended 30 September 2015 ... Income , 421,979 , 384,242 , ... , 34,719 , (18.3) Medical Insurance ... , 16.1 Medical Devices and Accessories Sales , ... Chinese Herbal Medicines Sales , 2,822 , ...
(Date:11/30/2015)... Calif. , Nov. 30, 2015 /PRNewswire/ ... the norm in U.S. medical imaging is ... increasingly popular accountable care payer-provider contracts are ... and, in their wake, alter provider-vendor relationships. ... payments will push forward new purchasing frameworks ...
(Date:11/30/2015)... Nov. 30, 2015 Oramed Pharmaceuticals Inc. (NASDAQ: ... the development of oral drug delivery systems, announced today ... at up to $50,000,000 with Hefei Tianhui Incubator of Technologies Co., Ltd. ... capsule, ORMD-0801, in China , ... . The agreements were signed at the Israel ...
Breaking Medicine Technology: