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A new key to detecting deadly aortic aneurysms
Date:10/24/2007

New Haven, Conn.Yale scientists have discovered a way to use a simple blood test that may accurately detect thoracic aneurysm disease (TAA), which gives little warning and is almost always fatal if untreated.

The study, published this month in Public Library of Science (PLoS), represents the collaborative work of Yale School of Medicine, Applied Biosystems, and Celera Diagnostics.

TAAs occur in the part of the aorta that passes through the chest. They can become huge without causing symptoms. In fact, only one in 20 patients has symptoms before internal rupture occursmaking advance detection key to treatment. Once the aneurysm ruptures, a person can go into shock and die from internal bleeding. Currently detection of these aneurysms is made by relatively expensive tests such as a chest X-ray or CT scantypically when a patient is being evaluated for other conditions.

A standardized blood-based test capable of detecting individuals at risk for aneurysm disease would represent a major advance in clinical care, said John Elefteriades, M.D., section chief of cardiothoracic surgery. This study indicates we may be able to develop such a test.

In this study Elefteriades and his colleagues took blood samples from 58 persons diagnosed with TAA disease and 36 spouses who did not have the disease. Using a gene expression profiling technology, they identified a 41-gene signature in blood cells that distinguishes TAA patients from those without the disease. The gene expression signature and the prediction model were identified using a complete workflow of instruments, reagents, and software from Applied Biosystems. These signature genes were further validated using TaqMan real-time PCR assays. The accuracy rate in various analyses is 78 percent to 85 percent.

It has become increasingly evident that the immune system plays a pivotal role in the development of aortic aneurysms, Elefteriades said. We thus hypothesized that gen
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Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

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