Navigation Links
A new key to detecting deadly aortic aneurysms
Date:10/24/2007

New Haven, Conn.Yale scientists have discovered a way to use a simple blood test that may accurately detect thoracic aneurysm disease (TAA), which gives little warning and is almost always fatal if untreated.

The study, published this month in Public Library of Science (PLoS), represents the collaborative work of Yale School of Medicine, Applied Biosystems, and Celera Diagnostics.

TAAs occur in the part of the aorta that passes through the chest. They can become huge without causing symptoms. In fact, only one in 20 patients has symptoms before internal rupture occursmaking advance detection key to treatment. Once the aneurysm ruptures, a person can go into shock and die from internal bleeding. Currently detection of these aneurysms is made by relatively expensive tests such as a chest X-ray or CT scantypically when a patient is being evaluated for other conditions.

A standardized blood-based test capable of detecting individuals at risk for aneurysm disease would represent a major advance in clinical care, said John Elefteriades, M.D., section chief of cardiothoracic surgery. This study indicates we may be able to develop such a test.

In this study Elefteriades and his colleagues took blood samples from 58 persons diagnosed with TAA disease and 36 spouses who did not have the disease. Using a gene expression profiling technology, they identified a 41-gene signature in blood cells that distinguishes TAA patients from those without the disease. The gene expression signature and the prediction model were identified using a complete workflow of instruments, reagents, and software from Applied Biosystems. These signature genes were further validated using TaqMan real-time PCR assays. The accuracy rate in various analyses is 78 percent to 85 percent.

It has become increasingly evident that the immune system plays a pivotal role in the development of aortic aneurysms, Elefteriades said. We thus hypothesized that gen
'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Detecting anomalies in heart rythm
3. Detecting brain aneurysms
4. New device for detecting artery blockages
5. Detecting Colorectal Cancer
6. Associated scan for detecting ovarian cancer spread
7. Photographs An Effective Tool In Detecting Skin Cancer
8. Mammograms The Best In Detecting Breast Cancer
9. Detecting Lung Cancer Early
10. Detecting Lung Cancer In Its Initial Stages
11. A New Way Of Detecting Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... VogueQueen.com, a well-known online supplier, now ... trends in garment fashion by providing graceful and sexy ... an all-inclusive array of sexy dresses , designed ... lot of customers take price into consideration. Worry no ... the purchase more affordable for all clients. , ...
(Date:7/29/2014)... Johns Hopkins researchers say they have discovered a chemical ... reactions that, if confirmed in larger studies, could give ... person,s risk of attempting suicide. , The discovery, described ... suggests that changes in a gene involved in the ... a significant role in turning what might otherwise be ...
(Date:7/29/2014)... July 29, 2014 The One Minute Herpes ... Alison Freeman, an herbal medicine specialist. Alison Freeman wanted to ... condition. , People interested in finding out more about ... can download it, as it is currently available in online ... of natural remedies and herbal medicine tips that can help ...
(Date:7/29/2014)... 2014 The Natural Multiple Sclerosis Treatment ... story to Gary M. Levin’s cure program. , ... for this serious disorder. Levin says that multiple sclerosis ... can be found in patients. , Dr. Gary ... many years, Levin has worked with patients suffering from ...
(Date:7/29/2014)... 2014 DailyGossip.org reveals in its Stop ... a new method of naturally overcoming sciatica, in less ... new method ensure sufferers that the cure is simple ... , The new method is described as very fast, ... with an 8 minutes per day treatment plan. ...
Breaking Medicine News(10 mins):Health News:VogueQueen.com Now Provides Graceful And Sexy Lingerie Collection For August 2Health News:A blood test for suicide? 2Health News:A blood test for suicide? 3Health News:One Minute to Herpes Cure Review Reveals Simplest Herpes Treatment 2Health News:Natural Multiple Sclerosis Treatment Review Reveals the Inside Story to Gary M. Levin’s Cure Program 2Health News:Stop Sciatica in 8 Minutes Review Reveals the Way to Cure Sciatica Easily 2
... ST. LOUIS, Nov. 5 Stereotaxis, Inc. (Nasdaq: STXS ... the gross margin, lower operating expenses and a significant reduction ... nine month period ended September 30, 2009. Revenue for ... 26% over $10.6 million for the 2008 third quarter. ...
... Dr. ... launching a powerful new website complete with the latest tools of the internet. Author of the ... website as an educational resource for visitors seeking treatment for an array of skin conditions. ... (Vocus) November 5, 2009 -- For those ...
... The Royal Thai ... as Thailand continues to see an increase in medical tourism. With an annual growth rate ... (TAT) and the Department of Export Promotion (DEP) expects to see two million visitors wanting ... ...
... ... in central North Carolina, today announced the expansion of their Invisalign Orthodontic services program with ... ... announce that it now has two dentists in the group practice, Dr. Brian Cahill and ...
... A ... Analgesia with Propofol Decrease the Incidence of Hypoxic Events? A Randomized, Controlled Trial", in ... procedural sedation by serving as an early warning system for respiratory depression. ... Jerusalem, Israel and ...
... Recent reports of H1N1 in a cat or pigs are likely ... -- When the news broke on Wednesday that a domestic cat ... feline by sick owners, many people no doubt wondered how vulnerable ... or Fido need protecting from this strain of flu? The answer, ...
Cached Medicine News:Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 2Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 3Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 4Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 5Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 6Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 7Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 8Health News:Houston and New York Cosmetic Dermatologist Paul M. Friedman, MD Launches Expansive New Website 2Health News:Houston and New York Cosmetic Dermatologist Paul M. Friedman, MD Launches Expansive New Website 3Health News:Thailand's Medical Tourism is Booming - Thailand on its Way to Become Asia's Medical Hub 2Health News:Thailand's Medical Tourism is Booming - Thailand on its Way to Become Asia's Medical Hub 3Health News:Research Triangle Dental Bolsters Invisalign Capabilities 2Health News:Capnography Monitoring Significantly Improves Patient Safety during Procedural Sedation in the Emergency Department 2Health News:Capnography Monitoring Significantly Improves Patient Safety during Procedural Sedation in the Emergency Department 3Health News:Capnography Monitoring Significantly Improves Patient Safety during Procedural Sedation in the Emergency Department 4Health News:Rest Easy. When It Comes to Swine Flu, Your Pet Is Safe 2Health News:Rest Easy. When It Comes to Swine Flu, Your Pet Is Safe 3
(Date:7/29/2014)... SALT LAKE CITY , July 29, 2014 /PRNewswire/ ... at The Grand American Hotel in Salt ... keynote speakers representing some of most respected healthcare organizations ... Health Catalyst , is an industry conference devoted ... of healthcare analytics,  an essential element of both accountable ...
(Date:7/29/2014)...  Novation, a VHA and UHC company, today ... features that automate key health care supply chain ... Association.  The new and enhanced ... Value Analysis, Item Master and Formulary – are ... most critical challenges brought on by health care ...
(Date:7/29/2014)...   Abide Therapeutics announced today the ... board of directors. Thornberry was previously senior vice ... Merck & Co. Inc., where she led discovery, ... diabetes, osteoporosis, fertility and contraception. Thornberry, a distinguished ... resulted in the discovery of Januvia TM , ...
Breaking Medicine Technology:Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 2Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 3Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 4Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 5Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 2Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 3Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 4Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 5Abide Therapeutics Appoints Nancy Thornberry to Board of Directors 2Abide Therapeutics Appoints Nancy Thornberry to Board of Directors 3
... is accepting applications for the ... or pre-clinical research focused on human protein therapies in ... The application deadline is April 1, 2011. ... protein products manufacturers in the world, launched the Octapharma ...
... 14 /PRNewswire-Asia-FirstCall/ -- Dehaier Medical Systems Ltd. (Nasdaq: ... an emerging leader in the development, assembly, marketing ... products in China, today announced that on October ... at the China International Medical Equipment Fair ("CMEF") ...
Cached Medicine Technology:Octapharma Accepting Applications for Research Grants Focused on Human Protein Therapies 2Dehaier Medical Shows New Products at 2010 China International Medical Equipment Fair 2Dehaier Medical Shows New Products at 2010 China International Medical Equipment Fair 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: