Navigation Links
A new ground zero for prostate cancer
Date:7/29/2010

hers distinguish luminal cells from basal cells. They then used these markers to separate the two cell types in samples of human prostate tissue. Patients undergoing prostate cancer surgery agreed to donate the tissue for research studies. In those operations, a surgeon typically removes healthy tissue along with the cancer. The tissue from those operations was given to Witte's team to provide the material they needed for their studies.

After separating luminal cells from basal cells, the researchers prodded all of the cells to become cancerous by introducing three genes known to promote prostate cancer. A virus was used to deliver the genes -- called AKT, ERG, and AR into luminal cells and basal cells.

The researchers then separately engrafted the transformed luminal cells and the transformed basal cells into mice. After 16 weeks, none of the luminal grafts had formed tumors. In the meantime, though, the basal cell grafts had gone through three stages: They had grown into prostate-like tubules, transformed into damaged pre-cancerous cells, and then turned malignant and formed tumors. Tellingly, when examined by a pathologist, these tumors looked identical to human prostate tumors, said Andrew Goldstein, a Ph.D. student in Witte's lab and first author on the Science paper.

"In our experimental model, basal cells show the ability to form the disease that looks like what we see in humans," says Goldstein. "We feel very confident that we have recreated something that strongly resembles human prostate cancer. We conclude that basal cells may be a source of the disease in humans."

The engrafted basal cells after turning cancerous also looked very much like luminal cells, as in clinical tumor samples. Witte says that this suggests that on their way to becoming cancerous, basal cells grow into more luminal-like cells. This makes sense, he notes, because the engrafted human basal cells also acted like prostate stem cells, growing into p
'/>"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Background music can impair performance, cites new study
2. The Institute for Health Metrics and Evaluation selects DatStat as the foundation for ground breaking healthcare project
3. New, Safe Playground to Be Built at Southwest Philadelphia Child Development Center
4. National Allergy Supply Announces Free Ground Shipping For Its Customers
5. Scientists offer solutions to arsenic groundwater poisoning in southern Asia
6. Ground-breaking study to improve quality of life and outcomes for kids born with heart defect
7. 10 Million Cigarette Butts Prevented from Touching the Ground in Spokane County, Washington, Thanks to Smart Smoke Electronic Cigarette
8. Spring into Summer with The Dirty Dozen Guide to Playground Safety
9. NextAid Presents BIDS BUILD HOPE Online Auction to Benefit Projects on the Ground in Africa on World AIDS Orphans Day
10. Lost Sense of Smell Noted Among Ground Zero Workers Post-9/11
11. Virginia Hospital Shared Services Corporation Selects Verified Credentials as its Exclusively Endorsed Provider of Background Screening Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining the main ... , Auto insurance quotes help many drivers find the ... to call an agent or visit an agency for price ... website: http://autocarinsurancebest.com/ . , Every business who relies heavily ...
(Date:1/22/2015)... A study recently published in ... Medicine & Science in Sports & Exercise shows ... reduce gastrointestinal (GI) problems associated with physical strain ... the double-blind, placebo-controlled study took 10 grams of ...
(Date:1/22/2015)... Four years since the release of their debut recording Love is ... Avasa & Matthew Love – the duo are pleased to announce ... White Swan Records on February 24, 2015. , THE ROAD offers ... to all of us to walk out of the mire of ...
(Date:1/22/2015)... a famous dress online store for wedding dresses and other ... of wedding dresses , and launches a site-wide women’s dress ... on your big day; the wedding gown is the most ... find the most suitable wedding dress. Now, we are proud ...
(Date:1/22/2015)... State Forestry Institute of Mecklenburg-Vorpommern in ... support from GEOSYSTEMS, a dedicated Hexagon Geospatial and Intergraph ... Hexagon Geospatial’s ERDAS APOLLO for cataloging, managing, ... point clouds and documents. This effort will enable the ...
Breaking Medicine News(10 mins):Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... findings released today indicate that Americans awareness of nanotechnology ... the tiny nanoscale materials and nano-enabled devices and products ... technology that experts believe will usher in a new ... most Americans continue to prefer that government, not industry, ...
... Technologies Inc., a privately,held orthobiologics company, today announced that ... clearance for InQu(TM). InQu is,indicated for use as a ... bone graft,substitute in the extremities and pelvis. InQu ... optimize structural and biological properties to support bone cell,growth. ...
... as depressed, distraught were seldom questioned, study found , , ... disconnect between doctors and some of their neediest patients, ... fail to spot symptoms that raise suicide risk. ... and visit physicians while showing signs of depression or ...
... Cornell University will host more than 200 physicians ... the Northeast Wilderness Medical Conference, Sept. 26-28. Those attending ... by grappling with similar circumstances encountered in the wilderness., ... 11, 2001, disaster in New York City and the ...
... ... Disease, WHITE PLAINS, N.Y., ... with Hodgkin,lymphoma will put the blood cancer in focus. With more than ... awareness about Hodgkin lymphoma and other blood cancers. Hodgkin lymphoma begins ...
... dad in decision-making, researchers say , MONDAY, Sept. 24 (HealthDay ... participate in medical decisions made about their children while in ... parents, published in the October issue of the Journal ... confident talking with doctors, and parents whose child had been ...
Cached Medicine News:Health News:Poll reveals public awareness of nanotech stuck at low level 2Health News:Poll reveals public awareness of nanotech stuck at low level 3Health News:ISTO Technologies Receives 510(k) Clearance for a Novel Bone Graft Substitute and Bone Graft Extender 2Health News:Doctors Often Fail to Spot Suicidal Patients 2Health News:Doctors Often Fail to Spot Suicidal Patients 3Health News:In the Neighborhood: Blood Cancer Strikes Wisteria Lane 2Health News:Most Parents Have Say in Kids' Hospital Care 2
(Date:1/23/2015)... , Jan. 23, 2015 Tianyin Pharmaceutical Inc. ... that specializes in the development and sale of patented ... and active pharmaceutical ingredients (API) today announced the business ... API operation. 1. Following the September 2014 ...
(Date:1/22/2015)... MINNEAPOLIS, Jan. 22, 2015  Uroplasty, Inc. (NASDAQ: UPI ... markets innovative proprietary products to treat voiding dysfunctions, today ... ended December 31, 2014.  Global revenue for the ... $4.4 million, a new quarterly revenue record, as compared ...
(Date:1/22/2015)... AMGN ) today announced that it will report its ... 27, 2015, after the close of the U.S. financial markets. The ... community at 2 p.m. PT. Participating in the call from Amgen ... officer, and other members of Amgen,s senior management team. ...
Breaking Medicine Technology:TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
... - First Agent Ever to Demonstrate Significant ... 04, 2007 /PRNewswire-FirstCall/ -- Bayer,HealthCare Pharmaceuticals Inc. ... (sorafenib) tablets significantly,extended overall survival in patients ... versus those taking placebo by 44%,(HR=0.69; p-value=0.0006). ...
... GAITHERSBURG, Md.--(BUSINESS WIRE)--Jun 4, 2007 - GenVec, Inc.,(Nasdaq: ... data from the clinical development program of its ... on,gastrointestinal cancers at the annual meeting of American ... Mitchell Posner, of the,University of Chicago. An oral ...
Cached Medicine Technology:Nexavar Significantly Extends Overall Survival by 44% in Liver,Cancer Patients 2Nexavar Significantly Extends Overall Survival by 44% in Liver,Cancer Patients 3Nexavar Significantly Extends Overall Survival by 44% in Liver,Cancer Patients 4Nexavar Significantly Extends Overall Survival by 44% in Liver,Cancer Patients 5Nexavar Significantly Extends Overall Survival by 44% in Liver,Cancer Patients 6Nexavar Significantly Extends Overall Survival by 44% in Liver,Cancer Patients 7GenVec Announces Update of Safety and Efficacy Data from Pivotal,Phase II/III PACT Study of TNFerade at ASCO 2GenVec Announces Update of Safety and Efficacy Data from Pivotal,Phase II/III PACT Study of TNFerade at ASCO 3GenVec Announces Update of Safety and Efficacy Data from Pivotal,Phase II/III PACT Study of TNFerade at ASCO 4
... come back with better resolution, accuracy and ... 25 or 31 rings (same as TMS-1), ... provides high accuracy & repeatability. The small ... & provides extensive corneal coverage. The low ...
... Pachycam is the first compact and ... The OCULUS Pachycam has automatic ... pressure) in accordance with Shah or ... The OCULUS Pachycam is non-contact ...
World's first commercially available vacuum assisted biopsy device for MRI....
... stereotactic, ultrasound and MRI-guided vacuum assisted breast ... Use the patented, FDA-cleared ATEC system for ... advanced method of breast biopsy. Its compassionate ... who trust YOU.,12 Gauge Handpieces: Useful for ...
Medicine Products: