Navigation Links
A new drug treatment to close the window on colon cancer
Date:7/21/2010

Cancer surgery wreaks havoc on a body's immune system and stress hormones exacerbate the problem. As a result, about half of those who undergo surgery for tumor removal experience a recurrence of cancer in the same region or other parts of the body.

A new clinical approach being developed and tested by Tel Aviv University researchers may be the key to making cancer operations more successful. Prof. Shamgar Ben-Eliyahu, head of Tel Aviv University's Department of Psychology, has opened on a new frontier in cancer research: he is recruiting colon cancer patients for a new clinical study which will test a cocktail of drugs to prevent the negative effects of stress responses to surgery. If successful, it will help the immune system maintain its vigor and prevent the occurrence of new tumors.

Prof. Ben-Eliyahu described his method in a recent issue of the Journal of Immunology.

A more competent immune system

Prof. Ben-Eliyahu and other research teams have confirmed that a competent immune system is critical before, during and after surgery for tumor removal. However, stress responses of the body during this period jeopardize immune competence and facilitate tumor metastasis.

Combining two widely-known medications that affect immune and stress responses, Prof. Ben-Eliyahu has developed a formula he hopes will keep an immune system strong and prevent the recurrence of cancer. Already tested in animal models, the compounds will be employed in a clinical trial in Israel, for which Prof. Ben-Eliyahu's team is currently recruiting patients and funds. They hope to have 800 colon cancer patients participate in the trial, due to begin shortly.

Increasing survival 300%

According to Prof. Ben-Eliyahu, the main stress hormones that appear to negatively impact immune system functioning are released before and during surgery. He says that existing generic drugs could block the influence of these hormones, helping the body to better fend off the stressors of surgery.

In animal studies, Prof. Ben-Eliyahu found that by blocking these hormones he could increase long-term post-operative survival rates from cancer by as much as 300 percent. If his new study on human volunteers succeeds, it could set a new paradigm for cancer treatment and post-surgery recovery rates. "In rats and mice it works with great success, really beautifully," says Prof. Ben-Eliyahu.

In the upcoming trial, Prof. Ben-Eliyahu will boost patients' immune systems with his drug cocktail over a 20-day period, before, during and after surgery. The two compounds to be used in the study are a beta-adrenergic antagonist, which is used to treat hypertension and anxiety, and a Cyclooxygenase-2 inhibitor, used against inflammation and pain. Since the two drugs are already widely available and routinely used in the clinical setting, no patents need be filed for the application of these drugs.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related medicine news :

1. Improved treatment access requires end to portrayal of drug abusers as already dead
2. Writing checks that bounce: World continues to backtrack on HIV treatment
3. HIV/AIDS treatment curbs spread of disease: UBC-BC CfE study
4. New discovery brings hope to treatment of incurable blood cancer
5. Shoulder arthritis? What patients need to know before treatment
6. Rare Blood Vessel Disease Could Have New Treatment Option
7. NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
8. New treatment for crippling diabetic Charcot foot
9. Arsenic shows promise as cancer treatment, Stanford study finds
10. Universal HIV testing and immediate treatment could reduce but not eliminate HIV/AIDS epidemic
11. Discovery Opens Door for New Options in Prevention and Treatment of Mesothelioma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new drug treatment to close the window on colon cancer
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance ... care insurance companies have a waiver for care if the client has a cognitive ... the family pays for care, is often waived, so the benefits from their insurance ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional women, ... towards gender equality at their inaugural Summit in New York City in June. The ... social audience of over 3 million. To watch the Mobilize Women video, click ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Agile Software Development, has been awarded a contract by the Center for Medicare ... (BPA) aims to accelerate the enterprise use of Agile methodologies in a consistent ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 12, 2017   Divoti USA will engrave ... the standard of the latest FDA requirements, which stipulates new criteria ... Anyone in need of Medical ID jewelry such as Medical ID ... are engraved in terms of the new FDA requirements . ... Divoti offers this dark mark ...
(Date:10/11/2017)... -- Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an ... Puerto Rico , where the company ... Following a comprehensive onsite assessment, ... damage, temporary loss of power and minimal water damage ... operations have resumed, and the company expects to return ...
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: