Navigation Links
A new computational technique predicts side-effects of a major cancer drug
Date:11/28/2007

Researchers at the University of California San Diego have developed a novel computer technique to search for the side effects of major pharmaceuticals. The study, reported November 30 in PLoS Computational Biology relates to a class of drugs known as Select Estrogen Receptor Modulators (SERMs), which includes tamoxifen, the most prescribed drug in the treatment of breast cancer.

Unexpected side effects account for one-third of all drug development failures and result in drugs being pulled from the market. Typically drugs are tested using an experimental method which aims to identify off-target proteins that cause side effects. The team in this study, led by Drs. Philip Bourne and Lei Xie, propose a computational modeling approach. If broadly successful the approach could shorten the drug development process and reduce costly recalls.

Rather than considering a single human protein to which a very large number of potential small molecule drugs can bind, Bourne et al. take a single drug molecule and look for how it might bind to as many of the proteins encoded by the human proteome as possible.

The team uses a case study focusing on SERMs to illustrate their technique. They report a previously unidentified protein target for SERMs which is supported by both biochemical and clinical data with known patient outcomes. The identification of a secondary binding site with adverse effects opens the door to changing the drug to maintain binding to the intended target, but to reduce binding to the off-target. This work is just the beginning of the process and experimental validation is continually needed.

By identifying new binding sites the computer analysis may also contribute to repositioning existing drugs to treat completely different diseases from those originally intended. Bourne and Xie are now working in this direction.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Page: 1

Related medicine news :

1. Carnegie Mellon Establishes Ray and Stephanie Lane Center for Computational Biology
2. Eye-staining technique offers early detection for dry eye syndrome
3. New technique detects specific chromosomal damage, may indicate lung cancer risk
4. The Pharma & Life Sciences Best Practice Database: an Industry Resource for Successful Techniques and Performance Benchmarks for Reaching the Top
5. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
6. Accuray Receives FDA Clearance for New Dose Calculation Technique for Body Radiosurgery
7. Radiation therapy technique reduces length of prostate cancer treatment
8. Radiation therapy technique reduces length of prostate cancer treatment
9. IVF technique enables pregnancy without multiple births, Stanford researchers find
10. UT Southwestern investigating hypothermic technique in treating pediatric head injuries
11. UCLA doctor develops new technique to treat varicose veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... , ... August 31, 2015 , ... ... and accessible primary care, is enhancing its existing presence in Tennessee with the ... The location is the company’s second in Knoxville, sixteenth in Tennessee, and 148th ...
(Date:8/31/2015)... ... August 31, 2015 , ... People ... at a greater risk for injury, potentially because they are more susceptible to ... Graduate School of Public Health analysis discovered. , The research, published online ...
(Date:8/31/2015)... ... 31, 2015 , ... Castle Dermatology Institute now welcomes San Fernando Valley ... graduate of the University of California, Los Angeles. He graduated summa cum laude with ... California, Irvine Medical School. As a nationally recognized Regents Scholar, Dr. Ghasri was given ...
(Date:8/31/2015)... ... August 31, 2015 , ... The German ... content management system (CMS) and make website updates quicker and more flexible. The ... websites of the Bundesliga (the German equivalent of the U.S. Soccer Federation) more ...
(Date:8/31/2015)... ... August 31, 2015 , ... "While ... device that could effectively deliver oxygen with a lower risk of failure," explained ... way, I invented the Adam Device." , The Adam Device offers a quick, ...
Breaking Medicine News(10 mins):Health News:State-of-the-Art Urgent Care Facility Opening in Knoxville 2Health News:Television Viewing Linked to Higher Injury Risk in Hostile People 2Health News:Television Viewing Linked to Higher Injury Risk in Hostile People 3Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2Health News:On the Ball with FirstSpirit: German Soccer League (DFL Digital Sports) Opts for e-Spirit’s CMS 2Health News:InventHelp® Client's Invents Medical Device to Restore Respiratory Function (BGF-905) 2
... It's a day to be remembered of the 90 million ... Crescent Movement, who are the back bone of the movement//, ... assistance and support for the needy all over the world. ... personal sacrifices they make, even risking their lives at times, ...
... in Madhya Pradesh due to pregnancy related complications, owing to poverty, ... from the National Family Health Survey (NFHS), the Maternal Mortality rate ... out of every 100,000 women, 498 die either while delivering a ... ,Taking the Census figures, about 1.9 million children are born ...
... insurance scheme as they would no longer be covered by ... can go without insurance to save money which proves to ... serious medical problem. Even those who find jobs right ... there's often a waiting period before employer-sponsored coverage is bestowed ...
... effect a charge on cancer patients for powerful, intravenous ... being seriously considered by Ontario's Health Minister. ,George ... some due diligence and obviously we're closer to having ... the right thing said in a telephone interview yesterday. ...
... the bird flu threat, several countries have banned the import ... this juncture, when several countries are bothered about the spread ... perhaps the right time to understand that bird flu can ... order for a virus to jump from one species to ...
... University of North Carolina at Chapel Hill have managed to ... gene activity by modifying a molecular pathway// that was previously ... 5) in the journal Cell, also show that the new ... receptor, a protein that responds to androgen hormones. In this ...
Cached Medicine News:Health News:Salutations For The Selfless Heroes On World Red Cross Day 2Health News:At Least 25 Women Die Of Maternity Complications In MP Everyday 2Health News:Insurance Plans after Graduation 2Health News:Animal Facts About Bird Flu Transmission 2Health News:Researchers Purify Protein That Could Regulate Male Hormones 2
(Date:8/31/2015)... Aug. 31, 2015  Chiasma, Inc. (NASDAQ: ... octreotide capsules for the orphan condition acromegaly, today ... June 30, 2015 and provided a corporate update. ... a transformative time for Chiasma, as we successfully ... that our first New Drug Application (NDA) has ...
(Date:8/31/2015)... Thousands of people will peacefully demonstrate their frustration with ... at dozens of rallies across the country today. Since ... United States has experienced skyrocketing rates of ... yet the President has never once spoken publicly about ... President Obama , rally organizers compared his failure to ...
(Date:8/31/2015)... , Aug. 31, 2015 With ... cytometry is experiencing a rise in active partnerships. ... in underdeveloped nations to quantitate CD4 cell markers ... Logo - http://photos.prnewswire.com/prnh/20150831/262206LOGO ... the Global Flow Cytometry Market ( http://www.frost.com/nf0e ), ...
Breaking Medicine Technology:Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 2Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 3Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 4Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 5Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 6Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 7Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 8Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 9Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 3Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 4
... NINOVE, Belgium, August 25 20% ... (spitting up food) of their baby,and the accompanying discomfort ... the "British Medical Journal" group recently,published the results of ... 2006 in the Children,s gastroenterology department of the Brussels,University ...
... Aug. 24 New research published this month in ... injuries to children in motor vehicle crashes are rare, they are ... passenger restraints, and in children who also suffered traumatic brain injury ... from The Children,s Hospital of Philadelphia, The University of Pennsylvania and ...
Cached Medicine Technology:Medical World Recognises New Therapy for Reflux Babies 2Research Consortium Advances Understanding of Cervical Spine Injuries in Children Involved in Motor Vehicle Crashes 2Research Consortium Advances Understanding of Cervical Spine Injuries in Children Involved in Motor Vehicle Crashes 3
... It is powerful, lightweight, ... comfortable, soft, durable foam ... pad, covered by machine ... Flexible headband easily adjusts ...
Xenon surgical headlight system is durable, comfortable, lightweight and deliver dependable bright light through a patented shielded fiber optic bundle. It is easy to wear....
Solarc surgical headlight is durable, comfortable, lightweight and delivers the bright, white light expected from a xenon system, but at a fraction of the cost....
View Mex-3 is designed for out-patient surgery, hospital rounds and house calls....
Medicine Products: