Navigation Links
A new chemotherapeutic target for hepatocellular carcinoma
Date:10/25/2007

Hepatocellular carcinoma (HCC) is a major health problem worldwide. Currently, the only chance for obtaining a cure in patients with HCC is by either a surgical resection or liver transplantation. However, many HCCs with scattered tumors cannot be operated on. In such patients, effective alternative therapies need to be discovered in order to treat patients in the early stages of this disease.

An article to be published on 28 October in the World Journal of Gastroenterology proposes a new target for therapy. A study was conducted by Dr. Satoshi Mamori, of Jikei University, in which he evaluated tumor biopsies in order to confirm the diagnosis of HCC.

The immunohistochemical expression of survivin in liver tumor specimens obtained from 17 patients was studied. In addition, to determine the survivin expression in response to anti-cancer drugs in early stage HCC, the survivin expression was determined after treating HCC cells with anti-cancer drugs under hypoxic culture conditions.

Survivin is a member of a family of inhibitors of apoptosis protein (IAP), which has been implicated in both the control of cell division and the inhibition of apoptosis. Survivin is selectively expressed in most common human neoplasms and it also appears to be involved in tumor cell resistance to some anticancer agents and ionizing radiation. Several preclinical studies have demonstrated a down-regulation of the survivin expression/function by the use of anti-sense oligonucleotide, dominant negative mutants, ribozymes, small interfering RNAs and cyclin-dependent kinase inhibitors to increase the rate of apoptosis, while also reducing the tumor growth potential and sensitized tumor cells to various chemotherapeutic drugs and -irradiation using both in vitro and in vivo models of various types of human tumors.

The results and conclusions demonstrated survivin protein to be expressed in 64.7% of the cells in early HCC specimens (median). In early stage HCC with a tumor size > 10 mm, the expression rate ranged for 67.7 to 83.7%. Moreover, the survivin protein concentration in HCC cells increased with a combination of hypoxia and anti cancer drugs. With TACE, the conditions of hypoxia are maintained by embolisation over a long period of time. Therefore, this study suggests that survivin could be used as a potential useful therapeutic target for early HCC.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Cytokine IL6 as a New Chemotherapeutic Target for Ras-driven Cancers
2. Feeding channel created by malaria parasite - a new target for malaria treatments
3. In Search Of A New Drug To Target Cholesterol
4. Enzyme may be target for obesity drugs
5. Target for obesity treatment
6. Scios Inc. targets drug giants in arthritis war
7. Pharmaceutical companies are targeting patients
8. New target for antidiabetic agents identified
9. Gel Offers A More Targeted Approach
10. In Search Of A New Drug To Target Cholesterol
11. Target of diabetes type 1 identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... The ... industry, today released ten predictions on the future of wellness, travel, spa and beauty ... top travel, spa and beauty companies to leading economists and researchers - to forecast ...
(Date:5/31/2016)... ... May 31, 2016 , ... Spectrum Aquatics has launched a brand new ADA ... and built with the user in mind. , “Over the last two years our ... an ADA 400 lbs lift is a necessary requirement for certain facilities with specific ...
(Date:5/31/2016)... ... 2016 , ... Phynd Technologies, Inc. announced recently the signing of three new ... Shore Medical Center – Somers Point, NJ. The new clients range in bed size ... breadth of Phynd’s solution and its interoperability. , Houston Methodist is a leading academic ...
(Date:5/31/2016)... ... 31, 2016 , ... MinerEye today announced that it has ... report by Gartner1 Inc. , Each year, Gartner identifies new Cool Vendors in ... vendors and their products and services. , According to Gartner, “Gartner's Cool Vendors ...
(Date:5/31/2016)... , ... May 31, 2016 , ... ... apply information technology solutions to the healthcare industry, The University of Scranton is ... offers an accelerated path to a career in rapidly growing field of healthcare ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... 31, 2016 Aloe vera extracts ... cosmetics and pharmaceuticals, with global volume to surpass 60,720.4 ... Bn. Demand for aloe vera extracts for ... will continue its upward momentum in 2016 as well. ... positive sentiment on aloe vera, with wide-ranging applications in ...
(Date:5/31/2016)... 31, 2016 The global biomaterials market ... surging prevalence of deaths from chronic diseases. According to research ... By Country): Opportunities and Forecasts (2016-2021) - (By Value; By ... Plastic Surgery, Wound Care); By Region-North America, Europe ... Germany , Italy , ...
(Date:5/31/2016)... , May 31, 2016 , Isansys ... for its Patient Status Engine wireless patient monitoring platform, as ... , Germany , Scotland ... company,s 2 nd generation system, launched earlier this year, is ... world , , This new technology significantly ...
Breaking Medicine Technology: