Navigation Links
A new approach to HIV vaccine development

To support their research for a vaccine against the HI-Virus, Prof. Dr. Klaus berla of the Faculty for Medicine at the Ruhr-Universitt Bochum and his research team will receive $2.3 million in funding within the next three years from the Bill & Melinda Gates Foundation. The scientists are part of the Collaboration for AIDS Vaccine Discovery (CAVD), which seeks to speed up the development of an HIV-vaccine through a rigorous exchange of information, methods and reagents. "The project rests upon our observation that certain immunological reactions seem to increase the risk of HIV-infection," Prof. berla said. "We want to avoid these kinds of harmful immune system responses while still creating protective antibodies."

Earlier study: HIV-vaccine increases risk of infection

Prior attempts to develop vaccines against HIV have not been successful. The preparation that was used in the Merck Pharmacy's so-called STEP study actually increases HIV susceptibility. "It is extraordinarily important to understand why the vaccine has this effect," berla said. "These findings could have an enormous impact on the development of future substances." By building on the findings of the STEP study, the research team plans to develop a new vaccine that will undergo in vivo testing.

T helper cells: HIV-proliferation vs. antibody production

Earlier studies have shown that certain antibodies against the envelope proteins of HIV could protect from HIV infection. Important for such antibody production are the CD4 T helper cells. Different kinds of these T helper cells recognize different pathogens in the body and signal other cells to create the appropriate antibodies in response to the invasive microorganisms. However, reactive CD4 T helper cells are also where HIV multiples particularly quickly. Therefore, if the number of HIV-responsive CD4 T helper cells increases as a result of the vaccine, the effect is simultaneously helpful and hurtful.

Helping, not hurting

The aim of the research project "Induction of affinity-matured HIV Env antibodies in the absence of HIV-specific T helper cells" is to investigate a new immunization method. Scientists associated with the project want to produce HIV antibodies through the use of T helper cells whose purpose is the recognition of other pathogens, rather than those which recognize the presence of HIV. This would mean that the number of T helper cells which respond to HIV would not go up through vaccination, thereby making it more difficult for HIV to multiply. The effectiveness of this new immunization method will be determined in cooperation with Dr. Stahl-Henning of the German Primate Center in Gttingen.


Contact: Klaus berla
Ruhr-University Bochum

Related medicine news :

1. As painkiller overdoses mount, researchers outline effective approaches to curb epidemic
2. Informatics approach helps doctors, patients make sense of genome data
3. Triple-threat approach reduces life-threatening central line infections in children with cancer
4. A new approach for controlling the skyrocketing cost of health care
5. UCI microbiologists find new approach to fighting viral illnesses
6. NIH awards $7.8 million for innovative HIV vaccine approaches
7. Canada needs national approach to protect against drug shortages
8. A nonantibiotic approach for treating urinary tract infections
9. A hands-on approach to treating patients with pulmonary disease
10. GWU consensus report outlines new approaches for evaluating benefits and risks of obesity drugs
11. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
Post Your Comments:
(Date:11/26/2015)... ... November 26, 2015 , ... ... to discuss bioavailability and the need to integrate dose form selection in early ... with OBN, the membership organization supporting and bringing together the UK’s emerging life ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel ... self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes with ... work with any font, giving users limitless opportunities to stylize and create designs ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... for all, Water For Empowerment ™ attracts volunteers together who want to ... by empowering women as key stakeholders in the process. The non-profit launched its ...
(Date:11/25/2015)... ... November 25, 2015 , ... TyloHelo Inc , North ... , Sauna accessories help improve the bather experience in the sauna, and the ... for the purist looking for simplicity in design to accessories that encourage a ...
(Date:11/25/2015)... ... ... For the first time, Vitalalert is donating half of its earnings to ... between the two groups began in 2014 with Vitalalert pledging a portion of every ... founded in 1954 and is an international Christian-based health organization whose mission is to ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 --> ... SyMRI to find optimal contrast weighting of MRI for ... has signed a research agreement with SyntheticMR in order to ... SyMRI, it is possible to generate multiple contrast images from ... patient has left, thus making it possible to both fine ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the Global Cell Surface Testing ... Opportunities" report to their offering.  ... the addition of the  "2016 Future ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
Breaking Medicine Technology: