Navigation Links
A new approach to HIV vaccine development
Date:10/30/2012

To support their research for a vaccine against the HI-Virus, Prof. Dr. Klaus berla of the Faculty for Medicine at the Ruhr-Universitt Bochum and his research team will receive $2.3 million in funding within the next three years from the Bill & Melinda Gates Foundation. The scientists are part of the Collaboration for AIDS Vaccine Discovery (CAVD), which seeks to speed up the development of an HIV-vaccine through a rigorous exchange of information, methods and reagents. "The project rests upon our observation that certain immunological reactions seem to increase the risk of HIV-infection," Prof. berla said. "We want to avoid these kinds of harmful immune system responses while still creating protective antibodies."

Earlier study: HIV-vaccine increases risk of infection

Prior attempts to develop vaccines against HIV have not been successful. The preparation that was used in the Merck Pharmacy's so-called STEP study actually increases HIV susceptibility. "It is extraordinarily important to understand why the vaccine has this effect," berla said. "These findings could have an enormous impact on the development of future substances." By building on the findings of the STEP study, the research team plans to develop a new vaccine that will undergo in vivo testing.

T helper cells: HIV-proliferation vs. antibody production

Earlier studies have shown that certain antibodies against the envelope proteins of HIV could protect from HIV infection. Important for such antibody production are the CD4 T helper cells. Different kinds of these T helper cells recognize different pathogens in the body and signal other cells to create the appropriate antibodies in response to the invasive microorganisms. However, reactive CD4 T helper cells are also where HIV multiples particularly quickly. Therefore, if the number of HIV-responsive CD4 T helper cells increases as a result of the vaccine, the effect is simultaneously helpful and hurtful.

Helping, not hurting

The aim of the research project "Induction of affinity-matured HIV Env antibodies in the absence of HIV-specific T helper cells" is to investigate a new immunization method. Scientists associated with the project want to produce HIV antibodies through the use of T helper cells whose purpose is the recognition of other pathogens, rather than those which recognize the presence of HIV. This would mean that the number of T helper cells which respond to HIV would not go up through vaccination, thereby making it more difficult for HIV to multiply. The effectiveness of this new immunization method will be determined in cooperation with Dr. Stahl-Henning of the German Primate Center in Gttingen.


'/>"/>

Contact: Klaus berla
virologie@ruhr-uni-bochum.de
49-234-322-3189
Ruhr-University Bochum
Source:Eurekalert

Related medicine news :

1. As painkiller overdoses mount, researchers outline effective approaches to curb epidemic
2. Informatics approach helps doctors, patients make sense of genome data
3. Triple-threat approach reduces life-threatening central line infections in children with cancer
4. A new approach for controlling the skyrocketing cost of health care
5. UCI microbiologists find new approach to fighting viral illnesses
6. NIH awards $7.8 million for innovative HIV vaccine approaches
7. Canada needs national approach to protect against drug shortages
8. A nonantibiotic approach for treating urinary tract infections
9. A hands-on approach to treating patients with pulmonary disease
10. GWU consensus report outlines new approaches for evaluating benefits and risks of obesity drugs
11. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... ... today announced rapid completion of the strategic executive team expansion needed to further ... to the ChenMed executive team,” says Christopher Chen, MD, ChenMed Chief Executive Officer. ...
(Date:3/23/2017)... ... ... Inflow IQ & Inflownomics of Raleigh, NC introduce a powerful information access network. ... experts in dangerous situations the Inflow IQ team can help people. Get ready ... & refreshing knowledge systems that enhance life. , Authentically enjoy 500 ...
(Date:3/23/2017)... ... March 23, 2017 , ... On 2 March ... the US Special Operations Command’s Patriot Award. The award was presented by the ... Force Dagger Foundation for its significant and enduring support to the command. ...
(Date:3/23/2017)... ... March 23, 2017 , ... “Beyond and Back”: a true-life testimony ... the creation of published author Bonetta Rose, a wife, mother and grandmother committed to ... by Christian Faith Publishing, Bonetta Rose‘s new book presents actual events in the life ...
(Date:3/23/2017)... ... ... Trainer”: an electrifying and suspenseful gunslinger novel with a twist. “The Trainer” is ... an enthusiasm for action and adventure stories. , Published by Christian Faith ... at the thirty-three notches that lined the edges of the wooden grip plates of ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 /PRNewswire/ - INVICTUS MD ... IVITF; FRA: 8IS) Invictus MD announces that AB Laboratories ... in its licensed production facility under the Access to ... Hamilton, Ontario . The ... in October 2016, is currently operating at half capacity, ...
(Date:3/23/2017)... 23, 2017 Piramal Pharma ... anuncia el nombramiento de Stuart E. Needleman ... de servicios integrados completa para su base de ... clave en el crecimiento y ejecución de las ... de impulsar todas las actividades de desarrollo empresarial ...
(Date:3/23/2017)... TEL AVIV, Israel, March 23, 2017  Galmed ... or the "Company"), a clinical-stage biopharmaceutical company focused ... for the treatment of nonalcoholic steatohepatitis, or NASH, ... for the three and twelve months ended December 31, ... recently completed pre-clinical studies demonstrating Aramchol™,s potential direct ...
Breaking Medicine Technology: