Navigation Links
A new approach to Alzheimer's disease research
Date:6/4/2014

As part of its ongoing research to better understand the complexities of the human brain, the Allen Institute for Brain Science is embarking on the first effort to map connectivity patterns across the whole brain in mouse models of Alzheimer's disease, through its recent award of a $3.4 million grant over five years from the National Institute on Aging of the National Institutes of Health.

"Many studies on Alzheimer's disease focus on just one or a small number of areas in the brain, such as the hippocampus, for its role in memory," says Julie Harris, Assistant Investigator at the Allen Institute for Brain Science and primary investigator on the grant. "By studying connections across the entire cortex in both normal mice and mouse models of the disease, we hope to finally make the breakthroughs that will help us understand the pathways through which Alzheimer's disease spreads, and what interventions we can make against its progression."

According to the National Institute on Aging, Alzheimer's disease is characterized by diminishing memory and thinking skills, affecting as many as 5.1 million Americans, most over the age of 60. The causes of Alzheimer's disease are still largely unknown, though they are likely a combination of genetic, environmental and other factors.

So far, clinical trials for drugs developed in mouse models that typically focus on individual brain areas have yielded poor results. "Our expanded view of the disease that looks at connections across the whole brain will hopefully improve mouse models and their use in translational research to identify drugs and treatments that work in humans," says Harris.

The whole-brain model of Alzheimer's builds on the Allen Mouse Brain Connectivity Atlas, recently profiled in the journal Nature , which allows researchers to quantitatively analyze connections across the entire mouse brain.

Harris and her colleagues plan to expand the resource by focusing on areas of the brain that are hardest hit early in the disease. They will work backwards first, using viral tracers to discover which regions of the brain send their neurons to those hard-hit areas. Then, they will follow the other projections from those source regions to different parts of the brain, ultimately creating a detailed map showing how and which brain regions are interconnected, and how these connections are altered by disease. In the spirit of other Allen Institute resources, they plan to make the data publicly available through the Allen Brain Atlas data portal at brain-map.org.

"This is the kind of meaningful research that can only be done at a place like the Allen Institute," says Allan Jones, CEO of the Allen Institute for Brain Science. "Our ability to process enormous amounts of exceptionally high quality data makes us uniquely equipped to develop this valuable new perspective on a disease that has troubled researchers for decades, and that will hopefully yield new insights that will lead to effective treatments."


'/>"/>

Contact: Steven Cooper
steven.cooper@edelman.com
415-486-3264
Edelman Public Relations
Source:Eurekalert

Related medicine news :

1. Unique approach needed to accurately assess health of young adult cancer survivors
2. MU receives national award for using mind-body approach to improve health
3. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
4. Editorial calls for comprehensive approach to cancer screening
5. Rutgers team discovers novel approach to stimulate immune cells
6. National initiative launched to change the way biology departments approach undergraduate education
7. A systems approach to preventing obesity in early life
8. Mount Sinai researchers develop a multi-target approach to treating tumors
9. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
10. A non-antibiotic approach for treating urinary tract infections
11. SingleSource Background Screening Company Calls On Adults To Take Proactive Approach To Stop Child Sexual Abuse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... "ProBrand Flip allows FCPX editors ... said Christina Austin - CEO of Pixel Film Studios. , ProBrand Flip includes 30 ... drop zones. Editors can select from a variety of flip book animations. In Addition, ...
(Date:12/7/2016)... ... December 07, 2016 , ... Bioelectronic ... Plus for consumers and healthcare professionals to manage chronic and acute pain. ... treatment modalities available in a single device. The announcement is part of ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... “The Road ... is an everyday trial, not a one hour a week showing of hands. “The ... businessman. , Tom begins, “Perhaps you are familiar with the brass ring that you ...
(Date:12/7/2016)... ... ... With God: Inspirational Lessons from My Life's Journey”: a sometimes serious, sometimes humorous ... in their lives. “Walking With God: Inspirational Lessons from My Life's Journey” is the ... , Sanford says, “I enjoy sharing the true stories in my book as examples ...
(Date:12/7/2016)... ... (PRWEB) December 07, 2016 , ... ... for individuals impacted by cerebral cavernous angiomas, was awarded a grant from the ... patient engagement program. New Mexico has more people with cavernous angioma than anywhere ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... N.Y. , Dec. 6, 2016 ... a reason to be hopeful.  A special kind of ... a less anxious life. Photo - ... Robert Buck, the psychotherapist who developed and ... breakthrough approach to overcoming anxiety and worry.  "Anxiety ...
(Date:12/5/2016)... , Dec. 5, 2016  Zimmer Biomet Holdings, ... announced that, pursuant to its previously-announced cash tender ... in the table below (collectively, the "Notes"), approximately ... validly tendered and not validly withdrawn on or ... time, today, December 5, 2016 (the ...
(Date:12/5/2016)... France Glaucoma Surgery Devices Market Outlook to 2022 ... Market Outlook to 2022", provides key market data on ... value, in millions of US dollars, volume (in units) ... Micro Catheters and Glaucoma Drainage Devices. The report ... each of these market segements, and global corporate-level profiles ...
Breaking Medicine Technology: