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A new agent for the treatment of patients with myelodysplastic syndrome; and more
Date:2/11/2008
A new agent for the treatment of patients with myelodysplastic syndrome
In a paper published this week in PLoS Medicine, Azra Raza and colleagues (University of Massachusetts) use gene expression profiling to identify a molecular signature that predicts response to lenalidomide in patients without chromosome 5q deletions. This suggests that these patients have a defect in erythroid differentiation.
In a related review article, Jerry Radich (Fred Hutchinson Cancer Research Center, Seattle, USA) reviews key research on the biology underlying treatment response in myelodysplasia, including Raza and colleagues' new study.
Citation: Ebert BL, Galili N, Tamayo P, Bosco J, Mak R, et al. (2008) An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome. PLoS Med 5(2): e35.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE
VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050035
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-02-raza.pdf
CONTACT:
Azra Raza
University of Massachusetts
Division of Hematology Oncology
Worcester, MA 01605
United States of America
araza@aptiumoncology.com
Related PLoS Medicine perspective article:
Citation: Radich J (2008) Solving the mystery of myelodysplasia. PLoS Med 5(2): e40
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE
VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=1
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| Contact: Josh Eveleth jeveleth@plos.org 415-624-1234 Public Library of Science Source:Eurekalert |
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