Navigation Links
A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found
Date:10/29/2008

The potential role of Eph receptor and ephrin ligand family in human cancer is receiving increasing attention. Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins. EphA4 reportedly forms a hetero receptor complex with FGFR1 and that EphA4/FGFR1 complex potentiates FGFR-mediated downstream signal transduction. However, alterations of EphA4 are not well understood in gastric cancer.

A research article to be published on October 7, 2008 in the World Journal of Gastroenterology will adress this question. This study was conducted by a team led by Dr. Hiroyuki Yamamoto of Sapporo Medical University in which they systematically analyzed expression of EphA4, FGFR1, and ephrins in gastric cancer.

Using reverse transcription-PCR (RT-PCR), real-time RT-PCR, immunohistochemistry, and cell growth assays, the research team analyzed the expression and role of EphA4 in gastric cancer, in relation to clinicopathological characteristics and the expression of FGFR1 and ephrin ligands. EphA4 overexpression at protein level was found and significantly associated with depth of invasion, recurrence, poor prognosis, and FGFR1 overexpression. The mRNAs for ephrin ligands were coexpressed in various combinations in gastric cancer cell lines and cancer tissues. Downregulation of EphA4 expression by siRNA resulted in a significant decrease in cancer cell growth in vitro.

In the view of the team, EphA4 is the first Eph/ephrin family member of which prognostic significance was shown in gastric cancer. EphA4 reportedly forms a hetero receptor complex with FGFR1 and that the EphA4/FGFR1 complex potentiates FGFR-mediated downstream signal transduction. FGFR1 expression was correlated with EphA4 expression. Therefore, EphA4 may play a role in gastric cancer, at least in part, through the interaction with FGFR signaling.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers create first model for retina receptors
2. Turned-off cannabinoid receptor turns on colorectal tumor growth
3. Intestinal Gluten Receptor Is Gateway for Celiac Disease
4. Neuroscientists show insulin receptor signaling regulates structure of brain circuits
5. Common bowel problem linked to chili pepper pain receptor
6. Novel toxin receptor discovered for ulcer-causing stomach pathogen
7. Some like it hot! Structure of receptor for hot chili pepper and pain revealed
8. Ashwell receptor reduces mortality during sepsis
9. Lumenis Launches HoLEP Preceptor Program at American Urology Association 2008 Annual Meeting
10. TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
11. Stopping a receptor called nogo boosts the synapses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... , ... May 27, 2016 , ... ... to help educate the many who are unaware of the plight of aphasia. ... will run within the “Stroke Awareness” campaign. , The link between stroke and ...
(Date:5/27/2016)... , ... May 27, 2016 , ... ... scholarships to students studying complementary medicine. Allison Outerbridge is this year’s Life ... award on May 18 at the university’s Student Leadership Awards ceremony. , Outerbridge ...
(Date:5/26/2016)... New Hampshire (PRWEB) , ... May 26, 2016 , ... ... skin care products, has been honored with a 2016 When Work Works Award for ... prestigious award, part of the national When Work Works project administered by the Families ...
(Date:5/26/2016)... ... ... Connor Sports, through its Connor Cares initiative, will continue to expand ... Tour that will commemorate the Indiana Fever legend’s hall-of-fame career and final WNBA ... levels of the game, Connor Sports has committed to a significantly increased focus on ...
(Date:5/26/2016)... , ... May 26, 2016 , ... There are nearly ... than 32 million cancer survivors worldwide. On Sunday, June 5, 2016, communities around the ... National Cancer Survivors Day®. , National Cancer Survivors Day® is an annual worldwide ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 According ... Share, Development, Growth and Demand Forecast to 2022 - ... Pump and Others)" published by P&S Market Research, the ... million in 2015, and it is expected to grow ... type, the insulin pump segment is expected to witness ...
(Date:5/25/2016)... SOUTHLAKE, Texas , May 25, 2016 /PRNewswire/ ... today the issuance to it by the US ...  9,218,608. The company,s technology includes proprietary processes for ... claims for health and wellness programs, HIPAA compliance ... "Our ...
(Date:5/25/2016)... ReportsnReports.com adds "Chronic Cough ... provides an overview on therapeutic pipeline of Chronic ... therapeutics assessment by drug target, mechanism of action ... along with latest updates, and featured news and ... in the therapeutic development for Chronic Cough and ...
Breaking Medicine Technology: