Navigation Links
A natural dye obtained from lichens may combat Alzheimer's disease
Date:12/2/2011

A red dye derived from lichens that has been used for centuries to color fabrics and food appears to reduce the abundance of small toxic protein aggregates in Alzheimer's disease. The dye, a compound called orcein, and a related substance, called O4, bind preferentially to small amyloid aggregates that are considered to be toxic and cause neuronal dysfunction and memory impairment in Alzheimer's disease. O4 binding to small aggregates promotes their conversion into large, mature plaques which researchers assume to be largely non-toxic for neuronal cells. Further research with animal models is needed to determine whether this new approach by Dr. Jan Bieschke (Max Delbrck Center for Molecular Medicine, MDC, Berlin-Buch), Dr. Martin Herbst (Charit Universittsmedizin Berlin) and Professor Erich Wanker (MDC) in Berlin, Germany, will be useful for therapy development (Nature Chemical Biology, doi: http://dx.doi.org/10.1038/NCHEMBIO.719)*.

Protein misfolding is considered to be the cause of Alzheimer's, Parkinson's and also Huntington's disease. In a multistep process, proteins misfold and accumulate into large extra- or intracellular plaques. Researchers assume that small misfolded protein aggregates that are precursors of mature plaques are toxic for nerve cells and are the reason why they are eventually destroyed.

Dye from the Canary Islands

The dye orcein is isolated from lichens that grow on the Canary Islands, among other places. Lichens have been used for centuries to color fabrics and food. Eight years ago Professor Wanker screened hundreds of natural compounds to find potential candidate drug molecules for the treatment of neurodegenerative diseases. Among those substances he found orcein, a compound made up of about 14 small molecules. As these molecules might have different biological effects, the researchers in Berlin began to search for pure chemicals with simil
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Natural killer cells could be key to anthrax defense
2. New scarless surgery takes out tumors through natural skull opening
3. BU presents approach to access biorelevant structures by remodeling natural products
4. Natural processes can limit spread of arsenic in water, says study
5. Soy-based natural S-equol supplements improve crows feet skin wrinkles in menopausal women
6. For Kids, Natural Disasters Can Whip Up Worries
7. Bodys natural marijuana-like chemicals make fatty foods hard to resist
8. Study shows pine bark naturally improves heart function
9. Cooling system may build eggs natural defenses against salmonella
10. Natural Alzheimers weapon suggests better treatment
11. Cooling the brain during sleep may be a natural and effective treatment for insomnia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying women’s ... discounted prom dresses, most of which are priced under ... company, the promotion is valid until Jan. 22, 2015; ... UK market. , The prom dresses in this new ... A-line strapless, empire strapless chiffon, one shoulder, floor-length, V-neck ...
(Date:12/25/2014)... 2014 Helen Harris’ RP (Retinitis Pigmentosa) ... California after an 8 year battle with breast cancer. ... evening in her home in Woodland Hills California after ... , As the founder and volunteer ... pioneered and championed many of today's greatest breakthroughs in ...
(Date:12/25/2014)... risk of burns from fires and cooking accidents increases ... cautious, an expert says. "Between Thanksgiving and New ... coming in with burns," said Dr. Steven Sandoval, medical ... of Stony Brook University Hospital in New York. ... not careful, could quickly turn tragic," Sandoval said in ...
(Date:12/25/2014)... December 25, 2014 AngelWeddingDress.com tries its ... the online realm. Today, the business has introduced its ... site-wide prom dress promotion. , The new prom outfits ... and every dress lover. They are specially designed for ... prom dresses should visit its website before Jan. ...
(Date:12/25/2014)... 2014 Residents at Abernethy ... showed their generous spirit by providing holiday gifts ... Parenting Network- Grandparents Raising Grandchildren program. , Following ... the largest Christmas tree on the campus of ... residents of the Abernethy Village Association (AVA). Each ...
Breaking Medicine News(10 mins):Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Don't Let Burns Mar Your Holidays 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Retirement Community Residents Make Impact During Holiday Season 2
... for First Quarter and Second Quarter ... and 2006 - - Company to Hold Conference Call on April ... $290.9 million, up 18.7% - ... April 23 Symmetry Medical Inc.,(NYSE: SMA ), a leading independent provider of ...
... 60 orders for faster form of image-guided ... intensity-modulated radiation therapy, PALO ALTO, Calif., ... announced it has received more than 60 orders for,its new ... have been,concentrated in North America but have also come in ...
... April 23 The NCCA accredited the ... Trainer,Certification for a five-year period, expiring March ... in 1992, NESTA is a professional certification ... and enforcing education,examination, experience and ethics requirements ...
... urges Senators Cardin and Mikulski to quickly pass,companion bill ... AARP thanked the,supporters and cosponsors of the Protecting ... in the U.S. House of Representatives. The bill,prevents massive ... cuts proposed by the administration., "Today,s vote is ...
... says goal is to maintain strength, not gain it, while ... you,re an athlete or fitness enthusiast who suffers a strained ... to stop exercising. , , "Exercise can definitely be beneficial ... type, the injured area should be moved and not left ...
... of Entries Available Through Charities and Tour Groups, ... announced today that,registration for the Bank of America ... on to complete the 26.2-mile race, marking the ... still available,through affiliated charities and tour groups., ...
Cached Medicine News:Health News:Symmetry Medical Reports Full Year 2007 Financial Results 2Health News:Symmetry Medical Reports Full Year 2007 Financial Results 3Health News:Symmetry Medical Reports Full Year 2007 Financial Results 4Health News:Symmetry Medical Reports Full Year 2007 Financial Results 5Health News:Symmetry Medical Reports Full Year 2007 Financial Results 6Health News:Symmetry Medical Reports Full Year 2007 Financial Results 7Health News:Symmetry Medical Reports Full Year 2007 Financial Results 8Health News:Symmetry Medical Reports Full Year 2007 Financial Results 9Health News:Varian Medical Systems Announces Record Demand for New RapidArc(TM) Radiotherapy Treatment Capability 2Health News:Varian Medical Systems Announces Record Demand for New RapidArc(TM) Radiotherapy Treatment Capability 3Health News:Varian Medical Systems Announces Record Demand for New RapidArc(TM) Radiotherapy Treatment Capability 4Health News:Varian Medical Systems Announces Record Demand for New RapidArc(TM) Radiotherapy Treatment Capability 5Health News:The National Exercise & Sports Trainers Association Receives Accreditation of Its Personal Fitness Trainer Certification From the National Commission for Certifying Agencies (NCCA) 2Health News:AARP Thanks Maryland's Representatives for Supporting Bill to Protect People in Medicaid 2Health News:Exercise Plays Role in Recovery From Sports Injuries 2Health News:2008 Bank of America Chicago Marathon Registration Closes as Race Reaches 45,000 Participant Capacity 2
(Date:12/24/2014)... DUBLIN , Dec. 24, 2014  Actavis ... that the Company has received a complete response ... (FDA) for its New Drug Application (NDA) for ... for the treatment of hypertension.   Photo ... we are disappointed in the receipt of a ...
(Date:12/24/2014)... Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ... patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded ... preliminary financial results for the first quarter of ... Ended September 30, 2014 Financial Highlights: , ... in 1Q14 with gross margins improved to 52% ...
(Date:12/24/2014)... 2014 Soligenix, Inc. (OTCQB: SNGX) (Soligenix ... products that address unmet medical needs in the ... that on December 24, 2014 it closed its ... Company raised approximately $2.3 million in gross proceeds ... net proceeds from the offering to fund its ...
Breaking Medicine Technology:Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3
... N.C. , Feb. 4 Gorbec Pharmaceutical ... prescription pharmaceutical products, is opening a GMP-compliant analytical laboratory ... expand Gorbec,s current services for analytical method development and ... its U.S. customer base as well as develop a ...
... , Feb. 4 Genoptix, Inc. (Nasdaq: GXDX ), ... report its financial results for the fourth quarter and full-year 2009 after ... 2010 . , A conference call hosted by President and CEO, ... will take place on the same day at 2:00pm PST ...
Cached Medicine Technology:Gorbec Pharmaceutical Services, Inc. Announces the Launch of Its GMP Analytical Laboratory in China 2Genoptix, Inc. to Announce Fourth Quarter and Full-Year 2009 Financial Results 2Genoptix, Inc. to Announce Fourth Quarter and Full-Year 2009 Financial Results 3
Hartman Mosquito forceps, straight, 3 1/2"....
Curved 21 mm serrated jaws. Ring handle with ratchet lock. Non-magnetic and dull finish. Overall length 4.7 inches....
Straight shafts with 13 mm crisscross serrated platform with polished finish. Serrated handle....
Straight shafts with 15 mm long jaws. Serrated handle with polished finish. Crisscross jaws....
Medicine Products: