Navigation Links
A molecular switch is linked to a common breast cancer
Date:11/8/2007

Researchers have discovered that a molecular switch in the protein making machinery of cells is linked to one of the most common forms of lethal breast cancer worldwide. The discovery by researchers at NYU School of Medicine could lead to new therapies for the cancer, called locally advanced breast cancer (LABC).

Although precise data isnt available, LABC may account for 50 percent or more of breast cancers among women in developing countries, and 30 percent of breast cancers among socially disadvantaged and minority women in the United States. This type of cancer is defined by a large tumor that is about 2 inches or larger in diameter, about the size of a plum, when first diagnosed. The cancer may have spread into surrounding lymph nodes or other tissues. However, it hasnt yet spread to more distant areas in the body.

Without treatment, fewer than 20 percent of patients with LABC are living five years after their diagnosis. Unfortunately, even with appropriate treatments, this cancer is deadlier than other types of breast cancer that are detected earlier.

With funding from the Breast Cancer Research Foundation and the Department of Defense, Robert J. Schneider, Ph.D., the Albert B. Sabin Professor of Molecular Pathogenesis, and Silvia C. Formenti, M.D., the Sandra and Edward H. Meyer Professor of Radiation Oncology and Chairwoman of Radiation Oncology, and their colleagues at NYU School of Medicine have made LABC the focus of a coordinated effort to understand the disease.

This disease has not been sufficiently studied, in part because of the social, psychological, economic, and cultural barriers that may stand in the way of obtaining care, says Dr. Formenti.

Our study shows that an unusual molecular switch occurs that is essential for the development of these large tumors. We think that this switch could be a target for new therapies, says Dr. Schneider.

The new study is published in
'/>"/>

Contact: Pamela McDonnell
Pamela.McDonnell@nyumc.org
212-404-3555
New York University Medical Center and School of Medicine  
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A molecular switch is linked to a common breast cancer
(Date:8/20/2014)... of chronic users of codeine-containing cough syrups (CCS) ... white matter and associates these changes with increased ... diffusuion tensor imaging (DTI) (an MR imaging technique), ... matter integrity of chronic CCS users. Deficits were ... the inferior fronto-occipital fasciculus, which other studies have ...
(Date:8/20/2014)... News) -- Pigs, hearts transplanted into baboons survived for ... as previously achieved, researchers report. The work is ... organs to shorten transplant waiting lists. In this ... baboons, abdomens. The genetic engineering and new methods of ... the hearts to survive for more than a year. ...
(Date:8/20/2014)... Dennis Thompson HealthDay Reporter ... exercise may help older women avoid a condition that causes ... active postmenopausal women had a 10 percent lower risk of ... researchers report in the Aug. 20 issue of the ... enjoyed this protection against the heart rhythm disorder even if ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 The Board ... Perkins Eastman is pleased to announce the ... services in China and the surrounding region. ... Richard Sprow AIA has relocated to the ... career in healthcare planning and design and to better ...
(Date:8/20/2014)... PITTSBURGH, Aug. 20, 2014 A common approach to ... blood did not improve survival chances for people who ... experts at the University of Pittsburgh School of Medicine. ... PLOS One , suggest acute hemodialysis, an aggressive method ... failure, may not provide a definitive benefit to the ...
Breaking Medicine News(10 mins):Health News:Pigs' Hearts Beat for a Year in Baboons' Abdomens 2Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 2Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 3Health News:Perkins Eastman Expands Presence in China 2Health News:Perkins Eastman Expands Presence in China 3Health News:Pitt analysis questions use of acute hemodialysis treatment 2
... backboned animals, but recent study has shown that things ... of their skeletal development. These findings will be published ... scientists were able to find the very same protein, ... which is also found in all vertebrates with backbones ...
... that babies breastfed for six months have reduced respiratory ... was conducted by investigators at UC Davis Children's Hospital, ... Pediatrics, Center for Child Health Research. ,In ... Davis Children's Hospital, lead author, "We found that babies ...
... by the Canadian snacks company Frito Lay Canada has launched ... South Asians. ,40 chip flavours created and tested ... and wasabi for test marketing. Stores were stocking these chops ... South Asians annually spends $12.6 billion on retail goods and ...
... technique to test and identify 'dead regions' in the ... children is being developed by Karolina Kluk, a Cambridge ... for development of individualized hearing aids for children. ... patients regarding their sensitivity to a range of tones ...
... skin cancer is the most common tumor to be diagnosed. It ... University Hospital of Navarra. // Sadly, the incidence melanoma has been ... killer of women aged between 19 and 50 years. In the ... 9000 in just 10 years. ,Two main factors regarded ...
... use birth control patch are twice as likely to develop clots ... found. Recently, another study conducted on similar grounds // has revealed ... sides, women who use the patch have been urged to discus ... ,Women who use the patch may be at an increased ...
Cached Medicine News:Health News:New Test Offers Hope in Effective Hearing Aid Design for Babies 2Health News:New Technique Could Revolutionize Melanoma Diagnosis and Treatment 2
(Date:8/20/2014)... Calif. , Aug. 20, 2014 ... will be using advanced, ventilator technology from Covidien ... to care for patients. The ... more naturally, compared to conventional mechanical ventilation, and ... soon as possible. Patients on mechanical ventilation are ...
(Date:8/20/2014)... Aug. 20, 2014 Children aren,t the ... vaccinations to help prevent disease. The Centers for ... all adults, but currently, many adults are not ... National Immunization Awareness Month, and the American Lung ... especially those with lung disease, to talk with ...
(Date:8/20/2014)... -- Research and Markets  has announced the addition of ... their offering. Global Market Report of Pralmorelin ... and regionally ( Europe , Asia ... Latin America etc.). It captures Pralmorelin market trends, ... on three primary areas; manufacture methods & technology development, market ...
Breaking Medicine Technology:Torrance Memorial Medical Center Acquires Advanced Ventilator Technology to Enhance Patient Care 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 3Global Market Report of Pralmorelin 2
... Cascade M-4 is a manual ... all routine clotting assays - PTs, ... Designed for easy, inexpensive, low-volume testing, ... but big on features, offering time ...
... STA is a fully-automated, coagulation workstation ... immunological assays in true random access ... sample management offers high throughput and ... the need to interrupt current testing. ...
... ACL Advance can reduce costs ... lab. With its superior ACL ... easy to use coagulation analyzer ... Plus, the protective transparent cover ...
... Pro Professional Hemoglobin Testing System consists of ... strips, used in measuring total hemoglobin, from ... Pro provides the precision, accuracy and cost ... Pro Professional Hemoglobin Testing System is portable ...
Medicine Products: