Navigation Links
A molecular map for aging in mice
Date:11/28/2007

Researchers at the National Institute of Aging and Stanford University have used gene arrays to identify genes whose activity changes with age in 16 different mouse tissues. The study, published November 30 in PLoS Genetics, uses a newly available database called AGEMAP to document the process of aging in mice at the molecular level. The work describes how aging affects different tissues in mice, and ultimately could help explain why lifespan is limited to just two years in mice.

As an organism ages, most tissues change their structure (for example, muscle tissues become weaker and have slow twitch rather than fast twitch fibers), and all tissues are subject to cellular damage that accumulates with age. Both changes in tissues and cellular damage lead to changes in gene expression, and thus probing which genes change expression in old age can lead to insights about the process of aging itself.

Previous studies have studied gene expression changes during aging in just one tissue. The new work stands out because it is much larger and more complete, including aging data for 16 different tissues and containing over 5.5 million expression measurements.

One noteworthy result is that some tissues (such as the thymus, eyes and lung) show large changes in which genes are active in old age whereas other tissues (such as liver and cerebrum) show little or none, suggesting that different tissues may degenerate to different degrees in old mice.

Another insight is that there are three distinct patterns of aging, and that tissues can be grouped according to which aging pathway they take. This result indicates that there are three different clocks for aging that may or may not change synchronously, and that an old animal may be a mixture of tissues affected by each of the different aging clocks.

Finally, the report compares aging in mice to aging in humans. Several aging pathways were found to be the same, and these cou
'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... , ... For decades, researchers in the genetics field have theorized that the ... changing after development in the womb. Now, researchers from the Icahn School of Medicine ... life – a process which helps to switch genes on and off. This histone ...
(Date:7/1/2015)... York, NY (PRWEB) , ... July 01, 2015 ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – today announced that they will welcome four new members to their ...
(Date:7/1/2015)... ORANGE, Calif. (PRWEB) , ... July 01, 2015 ... ... advanced orthodontic technology and services, today announced that its fifth annual Smile for ... has raised $80,000 for the non-profit organization. In addition to supporting S4L in ...
(Date:7/1/2015)... Japan (PRWEB) , ... July 01, 2015 , ... ... 2015 of a new extraction plant for Linablue®, Spirulina-derived natural blue food coloring. ... Nutritionals, LLC, the DIC Group’s U.S. Spirulina* production base, began in May 2014. ...
(Date:7/1/2015)... ... ... The Collaborative for Children and Families (CCF) announced that it received a ... to improve quality of care and save costs for the child welfare sector by ... in New York’s Medicaid system. Experts agree that children need thorough solutions to live ...
Breaking Medicine News(10 mins):Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 2Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 3Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 4Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 2Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 3Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 4Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 5Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 2Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 3Health News:DIC Strengthens Its Position as the Global Leader for Natural Blue Food Coloring 2Health News:DIC Strengthens Its Position as the Global Leader for Natural Blue Food Coloring 3Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 2Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 3
... after markets close at 2:00 p.m. PT (5:00 p.m. ET) ... MASI ), the inventor of Pulse CO-Oximetry and Measure-Through Motion ... quarter and fiscal year 2008 financial results for the period ... March 3, 2009.A conference call to review the results will ...
... Its Roster, Fielding Five Teams to Spread Personal Messages ... 1 and Type 2 DiabetesBRIDGEWATER, N.J., Feb. 5 ... glargine [rDNA origin] injection) and rapid-acting insulin Apidra(R) (insulin ... sponsors of Team Type 1, a team of amateur ...
... Feb. 5 Palomar Medical Technologies, Inc. (Nasdaq: ... light-based systems for cosmetic treatments, today announced financial results ... 2008. Revenues for the quarter ended December 31, ... product revenues, $2.2 million were royalty revenues, $0.5 million ...
... TORONTO, Feb. 5 /PRNewswire-FirstCall/ - Transition Therapeutics Inc. ... TTHI ) today announced the completion of patient ... gastrin analogue, TT-223, in patients with type 2 ... dose-ranging study to evaluate the safety, tolerability and ...
... Health Records (EHRs) have been promoted by industry and ... controlling costs. However, actual adoption of EHRs has ... to implementation costs, security, privacy, and systems integration. ... adoption barriers pale in comparison to basic usability and ...
... and identity theft response leader Kroll Fraud Solutions will host webinars ... a team of Kroll data security experts. , ... ... theft response leader Kroll Fraud Solutions will host a ...
Cached Medicine News:Health News:Masimo to Report Fourth Quarter and Fiscal Year 2008 Financial Results on March 3, 2009 2Health News:Masimo to Report Fourth Quarter and Fiscal Year 2008 Financial Results on March 3, 2009 3Health News:Inspirational Teams of Athletes with Diabetes Build Momentum in 2009 with Sponsorship from Long-Acting Insulin Lantus(R) and Rapid-Acting Insulin Apidra(R) 2Health News:Inspirational Teams of Athletes with Diabetes Build Momentum in 2009 with Sponsorship from Long-Acting Insulin Lantus(R) and Rapid-Acting Insulin Apidra(R) 3Health News:Inspirational Teams of Athletes with Diabetes Build Momentum in 2009 with Sponsorship from Long-Acting Insulin Lantus(R) and Rapid-Acting Insulin Apidra(R) 4Health News:Inspirational Teams of Athletes with Diabetes Build Momentum in 2009 with Sponsorship from Long-Acting Insulin Lantus(R) and Rapid-Acting Insulin Apidra(R) 5Health News:Inspirational Teams of Athletes with Diabetes Build Momentum in 2009 with Sponsorship from Long-Acting Insulin Lantus(R) and Rapid-Acting Insulin Apidra(R) 6Health News:Inspirational Teams of Athletes with Diabetes Build Momentum in 2009 with Sponsorship from Long-Acting Insulin Lantus(R) and Rapid-Acting Insulin Apidra(R) 7Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 2Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 3Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 4Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 5Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 6Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 7Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 8Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 9Health News:Palomar Medical Reports Financial Results for Fourth Quarter and Fiscal Year 2008 10Health News:Transition Therapeutics Announces Completion of Patient Enrolment of Phase 2 Study of TT-223 in Type 2 Diabetes Patients 2Health News:How to Select an Electronic Health Record System That Healthcare Professionals Can Use 2Health News:Kroll Fraud Solutions To Host Free Webinar Series on Preparing for and Responding to a Healthcare Data Breach 2
(Date:7/1/2015)... DIEGO , July 1, 2015  Imprimis ... company focused on the development and commercialization of ... company will ring The Nasdaq stock market closing ... celebrating the growing success of its Go Dropless™ ... 3.6 million cataract procedures are performed annually in ...
(Date:7/1/2015)... Lupin , Strides ... MPP Sub-licensees to Fourteen Companies     ... expansion of its network of generic manufacturers to 14 companies ... antiretrovirals (ARVs). New companies Lupin and Strides Arcolab recently signed ... the MPP licensed from ViiV Healthcare two months after its ...
(Date:7/1/2015)... 2015  Celsion Corporation (NASDAQ: CLSN ), an ... H. Tardugno , Chairman, President and CEO, is scheduled ... on Wednesday, July 8, 2015, at 4:15 p.m. Eastern ... Hotel located at 119 W. 56th Street, ... copy of the presentation will be available in the ...
Breaking Medicine Technology:Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 2Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 3Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 4The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 2The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 3Celsion Corporation to Present at Cantor Fitzgerald's Inaugural Healthcare Conference on July 8, 2015 2
... HOFFMAN ESTATES, Ill., Nov. 10 Life Spine announced ... Invasive Spinal System. The AVATAR MIS ... screws. Combining the novel screw delivery system with ... designed to accommodate evolving surgical approaches, as well as ...
... MedPro Imaging, a premium provider of new and refurbished ... MC Ultrasound, a leading on-site ultrasound provider for high ... area. The acquisition marks yet another milestone in MedPro ... its commitment of providing quality ultrasound imaging solutions. , ...
Cached Medicine Technology:MedPro Imaging Acquires MC Ultrasound 2
... spinal procedures. The SpineAssist platform for enhancing ... solution that enables surgery to be performed ... currently answers a growing need for accurate ... pedicle screw insertion for spine fusion procedures. ...
ACRYSOF®, Posterior Chamber Intraocular Lenses are indicated for the replacement of the human lens to achieve visual correction of aphakia in patients sixty years and older. These lenses are i...
Single piece PMMA lens, AC depth: 4.7....
Single-Piece PMMA IOLs for the replacement of the human crystalline lens in the visual correction of aphakia....
Medicine Products: