Navigation Links
A microRNA prognostic marker identified in acute leukemia
Date:5/14/2012

COLUMBUS, Ohio A study has identified microRNA-3151 as a new independent prognostic marker in certain patients with acute leukemia. The study involves patients with acute myeloid leukemia and normal-looking chromosomes (CN-AML).

The study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) found that when microRNA-3151 (miR-3151) is overexpressed in CN-AML, the disease responds poorly to treatment and patients experience shorter remissions and survival periods. This effect is independent of other gene mutations that may be present in the cells.

Additionally, miR-3151 is encoded within a gene called BAALC, which itself is an independent marker of poor survival when overexpressed in CN-AML.

The findings, published online in the journal Blood, provide new insights into the nature of AML and might in the future help determine the best therapy for individual patients and further personalize AML therapy.

"Patients with high levels of both miR-3151 and BAALC had the poorest outcome compared with those showing high expression of either miR-3151 or BAALC alone, or those expressing low levels of both," says principal investigator Dr. Clara D. Bloomfield, a Distinguished University Professor at Ohio State and cancer scholar and senior advisor to the OSUCCC James. "This suggests that miR-3151 and BAALC may act through different mechanisms to enhance poor outcome of CN-AML patients."

The study involved 179 patients aged 60 years or older with CN-AML who were treated on Cancer and Leukemia Group B (CALGB) clinical trials.

MicroRNAs are small molecules that cells use to help regulate the kinds and amount of proteins they make. About one-third of human microRNAs are encoded within host genes. Specifically, they are located in the portions of genes called introns, short stretches of DNA that are not used when genetic information is tran
'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers identify key role of microRNAs in melanoma metastasis
2. Researchers find that inhibiting microRNAs may help prevent degenerative eye disorders
3. MicroRNA variations associated with earlier prostate cancer diagnosis in African-American men
4. Protein and microRNA block cellular transition vital to metastasis
5. MicroRNAs could increase the risk of amputation in diabetics
6. MicroRNA-TP53 circuit connected to chronic lymphocytic leukemia
7. MicroRNA controls mammary gland development in mice
8. Caltech biologists discover microRNAs that control function of blood stem cells
9. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
10. Cancer cells show rewired, fragmented microRNA networks
11. Study links microRNA to shut-down of DNA-repair genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... strongly associated with Alzheimer,s disease; however, researchers are still ... causal agent of the onset and development of the ... beta-amyloid is not harmful when found in isolation but ... to form the so-called amyloid fibrils , "We are ... with multiple ones because each aggregate of peptide, which ...
(Date:10/1/2014)... published today in the Journal of the American ... 50 years with moderate or severe chronic knee pain, ... the University of Melbourne randomly assigned 282 patients (50 ... acupuncture or sham or pretend laser treatment. , ... acupuncturists blinded to laser and sham (inactive) laser acupuncture. ...
(Date:10/1/2014)... Physical Sciences Research Council (EPSRC) will focus on ... systems which run, for example, manufacturing plants, power ... , The research will help understand and ... systems behind our critical national infrastructure. , ... (RITICS), based at Imperial College London, is co-ordinating ...
(Date:10/1/2014)... 2014) Despite a policy focus on expanding ... this vulnerable population continues to have significant dental ... Journal of the American Dental Association , researchers ... University School of Dental Medicine report on the ... oral care provided by caregivers to adults with ...
(Date:10/1/2014)... October 01, 2014 Familylifeinsurancequotes.org has ... life insurance for senior citizens. , Senior citizens ... will now sell coverage to seniors who are over ... be purchased without taking a medical examination. , Term ... online and senior clients can qualify. Having life insurance ...
Breaking Medicine News(10 mins):Health News:Laying siege to beta-amyloid, the key protein in Alzheimer's disease 2Health News:Study finds acupuncture does not improve chronic knee pain 2Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 3Health News:Affordable Term Life Insurance - Senior Citizens Can Qualify for Coverage! 2
... LLC, a leading provider,of real-time software products and ... Duluth, Minn.-based ALLETE, Inc, has selected InStep,s,eDNA historian ... health monitoring and analysis needs. , ... with several critical power delivery,systems and applications including ...
... 30 million drivers in the US aged 65 and over, ... no longer drive safely and decide that it,s time to ... decrease in vision function is a key factor in bringing ... Study (SEEDS) ( http://www.iovs.org/cgi/content/full/50/1/107 ), conducted by researchers affiliated with ...
... Web-Based Community for Parents of Children with DisabilitiesNEWTON, ... community for parents of disabled children, today announced ... to assist parents of children with disabilities, the ... resource library for families. ChildRC ( www.ChildRC.com ) ...
... middle age, study says , , TUESDAY, Jan. 6 (HealthDay News) ... painfully obvious, nutrition experts have been divided over whether cutting ... sometimes boomerang, triggering binge eating and weight gain. , But, ... particularly as you age. , Publishing in the current issue ...
... Two children have a seizure. One child never has another ... of seizures and is diagnosed with epilepsy. A study being ... what could possibly happen in the development of these two ... neurologic health. , The findings reveal that genetic predisposition, ...
... KENILWORTH, N.J., Jan. 6 Schering-Plough Corporation (NYSE: ... results for the 2008 fourth quarter and full year on ... that day, Schering-Plough will conduct a conference call to review ... Fred Hassan, Schering-Plough,s chairman and CEO, and other members of ...
Cached Medicine News:Health News:Minnesota Power Selects InStep's eDNA Historian Software for Enterprise Operational and Asset Health Related Data Management 2Health News:Vision problems prompt older drivers to put down the keys 2Health News:ChildRC.com Launches The Child Resource Center 2Health News:It Pays to Eat Less as You Age 2Health News:Study yields clues about the evolution of epilepsy 2Health News:Study yields clues about the evolution of epilepsy 3Health News:Schering-Plough Schedules Conference Call and Webcast for 2008 Fourth Quarter and Full Year Earnings 2
(Date:10/1/2014)... 2014 NeuroCall, Inc., ("NeuroCall") announced today that ... and Teleneurology services. Dr. Ricardo Garcia-Rivera , Founder ... extremely proud that our quality of service has been ... provide lifesaving support and continuity of care to patients ... the United States ." ...
(Date:10/1/2014)... Oct. 1, 2014   Cypher Genomics, Inc., ... J. Patrick Ravenel as chief technology officer. ... and systems experience and a proven track record of ... "Patrick has been recognized as a top ... and is known industry-wide for delivering innovative products that ...
(Date:10/1/2014)... , Oct. 1, 2014   Royal Philips ... today announced its eCareCoordinator and eCareCompanion telehealth applications ... and Drug Administration (FDA). A part of Philips ... , eCareCoordinator and eCareCompanion are focused on patient ... clinical applications to be available through the cloud-based ...
Breaking Medicine Technology:NeuroCall Awarded Joint Commission Accreditation 2Cypher Genomics Appoints J. Patrick Ravenel Chief Technology Officer 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 3Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 4
... May 15, 2012  Coloplast North America, a provider of ... has announced a corporate sponsorship of Michael Johnson, formula ... competing this year in The Cooper Tires USF2000 Championship ... to Indy, an open-wheeled development program for drivers seeking ...
... 2012 Medical Marijuana, Inc . (OTC: MJNA), ... and hemp industry innovators, today announced its first quarter ... million on gross revenues of $1.79 million for the ... revenue increase of 400 plus percent quarter-over-quarter when compared ...
Cached Medicine Technology:First Paralyzed Formula Race Car Driver's "Road to Indy" Sponsored By Coloplast 2Medical Marijuana, Inc. Announces First Quarter 2012 Results 2Medical Marijuana, Inc. Announces First Quarter 2012 Results 3Medical Marijuana, Inc. Announces First Quarter 2012 Results 4Medical Marijuana, Inc. Announces First Quarter 2012 Results 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: