Navigation Links
A little tag with a large effect
Date:2/4/2013

February 4, 2013, New York, NY and Oxford, UK Nearly every cell in the human body carries a copy of the full human genome. So how is it that the cells that detect light in the human eye are so different from those of, say, the beating heart or the spleen?

The answer, of course, is that each type of cell selectively expresses only a unique suite of genes, actively silencing those that are irrelevant to its function. Scientists have long known that one way in which such gene-silencing occurs is by the chemical modification of cytosineone of the four bases of DNA that write the genetic codeto create an "epigenetic" marker known as 5-methylcytosine (5mC). Appropriate placement of this marker is essential to many normal biological processes, not least embryonic development. Conversely, its erroneous distribution contributes to the evolution of a broad range of cancers.

But 5mC is not the only epigenetic marker on the genomic block. About three years ago at Rockefeller University, Skirmantas Kriaucionis, currently a Ludwig researcher based at Oxford University, and Nathaniel Heintz, of Rockefeller University, discovered that a second modification of cytosine that converts it into 5-hydroxymethylcytosine (5hmC) seems to play a similarly vital role in the selective expression of the genome. Since then, researchers have scrambled to figure out what precisely that role might be. In a recent issue of the journal Cell, Heintz, Kriaucionis and colleagues report that the 5hmC marker has an effect on gene expression opposite to that of 5mC, and identify how its signal is detected and broadly interpreted in the healthy brain cells of mice. Since changes in the distribution of 5hmC are known to take place in a broad range of tumor cells, these findings could prove to be of great value to cancer research.

To begin, the team mapped where exactly 5hmC is found across the genomes of three types of healthy mouse neural cells. They discovered that
'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Little House books Mary Ingalls probably did not go blind from scarlet fever, U-M study says
2. Could Being a Little Overweight Help You Live Longer?
3. Tumor boards linked to little association with effects on cancer care
4. Little evidence to support TB interventions in real-world, low-resource settings
5. Celebrating Little Girls – Children’s Brand mimvail Announces Debut Collection
6. Dr. Jason Littleton Selected for Special Episode of Dr. Oz Show Aired on December 13, 2012.
7. Despite hype, costly prostate cancer treatment offers little relief from side effects
8. Is Your Little One Scared of Santa?
9. Too Little Sleep Spurs Appetite-Boosting Hormones: Study
10. Too Much or Too Little Activity Can Spur Knee Problems
11. Little evidence of health benefits from organic foods, Stanford study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... a well-known casket manufacturer from China, has announced its newest ... executive officer has announced a new promotion for its funeral ... prices, from 15 to 26 percent off. , “As far ... in the current market. We are excited to release the ... high quality products for sale. Many of our clients are ...
(Date:7/13/2014)... Micro irrigation systems are mainly utilized for ... wells as to maintain soil quality. The application of ... a dominant revenue generator for manufacturers in future. The ... costs has led to the adoption of micro irrigation ... caused massive demand for micro irrigation systems, as they ...
(Date:7/13/2014)... 2014 Fuel additives are chemicals, which ... jet fuel, kerosene, and so on, in order to ... reducing the corrosion effects caused by fuels and improving ... any fuel, provide economies of scale in the long ... overall cost of the fuel products. , The various ...
(Date:7/13/2014)... New York, New York (PRWEB) July 13, 2014 ... much to bring attention to the cancer risks associated ... a chance to tell their story to federal regulators, ... of a U.S. Food & Drug Administration (FDA) ... Liebhard LLP reports. According to the Rochester Democrat ...
(Date:7/13/2014)... 13, 2014 Athletes with a certain ... from concussions, according to research presented today at the ... Annual Meeting. The research marks the first of its ... the known physical events that occur after a head ... long allele in the (GT)n genotype were four times ...
Breaking Medicine News(10 mins):Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2
... ST. LOUIS: Following Advanced Medical Optics' voluntary recall ... lens solution, doctors of optometry from the ... Section concur with the company's decision to remove ... has not been officially determined, health officials from ...
... Biochemical Zoology, a fascinating new selection of papers ... selection, providing insight into how organisms adapt ... ,Dr. James Hicks, Editor in Chief of PBZ, ... "This exciting approach experimental evolution allows ...
... against the myriad strains of the human immunodeficiency virus ... study conducted at the Uniformed Services University of the ... extremely variable, its prevention requires a vaccine effective enough ... can neutralise multiple viral strains. ,The ...
... new study has found that being exposed to pesticides, as ... of developing Parkinsons. ,The study, which is published ... Medicine, one of the BMJ Specialty Journals, states that the ... ,959 people suffering with Parkinsons, as well as 1,989 controls ...
... new research has found that HIV and malaria combine ... ,University of Toronto researchers have exposed the ... and have also discovered how the HIV virus works ... superior vaccines for pregnant women in malaria-ravished regions. ...
... Early data for an investigational device that specifically targets ... , called Tumor-Treating Fields (TTFields), has found that it ... patients with the most common and aggressive type of ... Novo-TTF, uses electrical fields to disrupt tumor growth by ...
Cached Medicine News:Health News:Optometrists Support AMO's Voluntary Contact Lens Solution Recall 2Health News:Research Throws Light on Adaptation of E.coli to Changing Conditions 2Health News:Risk of Parkinsons Increased by Exposure to Pesticide and Head Trauma 2Health News:Malaria and HIV Jointly Affects Pregnant Women and Their Infants 2Health News:Device That Targets Brain Cancer Shows Promising Results 2
(Date:7/10/2014)... July 10, 2014   Ventana Medical Systems, Inc. ... it has entered into an agreement with Merck KGaA, ... EMD Serono in the United States ... with Merck KGaA,s biopharmaceutical division on the development and ... target using Ventana,s proprietary diagnostic assays. In alignment with ...
(Date:7/10/2014)... Decision Resources Group finds that over half ... and Drug Administration,s (FDA) approval of Vifor Fresenius Medical ... approved by the FDA in November 2013 for the ... on dialysis. Other key findings from the ... : , Bundling: ...
(Date:1/15/2014)... Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the addition of ... Size, Share, Growth, Trends And Forecast, 2013 - 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 ) Dental consumables ... to treat dental impairments, for tooth restoration and in ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
... Feb. 8, 2011 The District of Columbia Patients Cooperative ... to provide high quality and affordable medical "marijuana" to qualifying ... implementation of DC,s new medical marijuana program.  The public meeting ... place on Thursday, February 10th at 7:00 pm in Pierce ...
... TUCSON, Ariz., Feb. 8, 2011 MRI Medical Inc. ... as part of its corporate development plan. ... provide our customers with the same superior design, development, ... years," stated Joseph Lee, Xeridiem Medical Devices, Inc.,s President. "Our ...
Cached Medicine Technology:February 10 Town Hall Meeting to Explain DC's New Medical Marijuana Program 2MRI Medical Inc. Changing Name to Xeridiem Medical Devices, Inc. 2
... instrument and custom filter wheels with ... The standard filter set includes: FAM/SYBR ... Red (585nm-610nm), Cy5 (635nm-665nm) and Cy3 ... analysis software, Beacon Designer oligo software, ...
... rapid, real-time thermal cycler used for identifying ... much of the testing process, and making ... the fastest, easiest to use, and most ... SmartCycler delivers highly accurate and consistent test ...
... SmartCycler System is a rapid, real-time thermal ... biological samples. By automating much of the ... individually programmable, it is the fastest, easiest ... on the market. The SmartCycler delivers highly ...
... The Applied Biosystems 7300 Real-Time ... real-time PCR capabilities with exceptional budget ... you to perform gene expression analysis, ... assays with internal positive controls ...
Medicine Products: