Navigation Links
A lethal brain tumor's strength may be a weakness as well
Date:8/14/2010

Malignant gliomas are the most common subtype of primary brain tumor and one of the deadliest. Even as doctors make steady progress treating other types of solid tumor cancers, from breast to prostate, the most aggressive form of malignant glioma, called a glioblastoma multiforme or GBM, has steadfastly defied advances in neurosurgery, radiation therapy and various conventional or novel drugs.

But an international team of scientists, headed by researchers at the Ludwig Institute for Cancer Research (LICR) at the University of California, San Diego School of Medicine, reports in the August 15 issue of Genes & Development that they have discovered a new signaling pathway between GBM cells one that, if ultimately blocked or disrupted, could significantly slow or reduce tumor growth and malignancy.

More than other types of cancer, GBMs are diverse assemblages of cell subtypes featuring great genetic variation. Anti-cancer therapies that target a specific mutation or cellular pathway tend to be less effective against such tumor heterogeneity.

"These myriad genetic alterations may be one of the primary reasons why GBMs are so lethal," said Frank Furnari, PhD, associate professor of medicine at the UCSD School of Medicine and an associate investigator at the San Diego branch of the LICR.

Even with maximum treatment effort, the median patient survival rate for a diagnosed GBM is nine to 12 months a statistic that has not changed substantially in decades.

However, Furnari, along with postdoctoral fellows Maria-del-Mar Inda and Rudy Bonavia, and Webster Cavenee, PhD, professor of medicine and director of the San Diego LICR branch, and others noted that in GBMs only a minority of tumor cells possess a mutant form of the epidermal growth factor receptor (EGFR) gene. These cells drive the tumor's rapid, deadly growth. "Most GBM tumor cells express wild-type or normal EGFR," said Furnari. "Yet when expressed by itself,
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Decline in Potentially Lethal Hospital-Based Infections
2. Potentially Lethal Airborne Fungus May Spread to California
3. Patients with Lethal Lung Disease Finally Receive Recognition by Social Security Administration
4. Deep Brain Stimulation Studied for Alzheimers
5. Menstrual Cramps May Alter Womens Brains
6. Menstrual cramps may alter brain structure
7. NIH award will enable design of brain tumor treatment that captures migrating cancer cells
8. Chemical system in brain behaves differently in cocaine addicts, UT Southwestern scientists find
9. Brain responds same to acute and chronic sleep loss
10. Brains wiring: More network than pyramid?
11. Better understanding of mapmaking in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... the University of California, San Diego School of Medicine ... assess the safety and efficacy of a new monoclonal ... most common form of blood cancer in adults. ... used by embryonic cells during early development and exploited ... the latter responsible for 90 percent of all cancer-related ...
(Date:9/16/2014)... LINCOLN, R.I. (PRWEB) September 16, 2014 ... from Sunday, Sept. 14, through Saturday, Sept. 20, ... make sure children are safe and secure while in ... from the National Traffic Highway Safety Administration (NHTSA), ... did not read the instruction manual when installing child ...
(Date:9/16/2014)... 16, 2014 CarePoint Health is ... Leigh Montes, MD, has joined our expanded Bariatric ... Hospital. Our system welcomes Dr. Montes to the ... surgical weight loss center, helps patients achieve long-term ... surgery procedures, including Gastric Sleeve, Gastric Bypass, LAP-BAND ...
(Date:9/16/2014)... Pittsburgh, PA (PRWEB) September 16, 2014 ... recovering well today after undergoing successful heart transplantation surgery ... , Mr. Tekulve, who spent most of his 16-year ... the team as a commentator for Root Sports Pittsburgh, ... his transplant surgeon, Stephen Bailey, MD, surgical director of ...
(Date:9/16/2014)... (HealthDay News) -- Illegal drug use among teens in the ... federal report. Encouragingly, the new study also found ... products among young people between the ages of 12 and ... survey of 70,000 people aged 12 and older across the ... or abuse problems among this age group also dropped from ...
Breaking Medicine News(10 mins):Health News:Novel drug targeting leukemia cells enters clinical trial 2Health News:Amica Offers Tips During Child Passenger Safety Week 2Health News:Top Bariatric Surgeon Joins CarePoint Health 2Health News:Top Bariatric Surgeon Joins CarePoint Health 3Health News:Former Pittsburgh Pirates Pitcher and Baseball Analyst Kent Tekulve Undergoes Successful Heart Transplant at Allegheny General Hospital 2Health News:Former Pittsburgh Pirates Pitcher and Baseball Analyst Kent Tekulve Undergoes Successful Heart Transplant at Allegheny General Hospital 3Health News:Fewer U.S. Teens Using Illegal Drugs and Alcohol, Report Finds 2
... Chemo-radiation therapy looks to kill cells on organ,s surface, ... (HealthDay News) -- Patients are being recruited for a ... protocol for pleural mesothelioma, a cancer of the lung,s ... , Currently, the standard treatment is to remove the ...
... how the nervous system and the immune system interact, scientists at The ... which the brain and the spleen communicate. , ... Manhasset, NY (PRWEB) ... nervous system and the immune system interact, scientists at The Feinstein ...
... T. Kennedy DSc, Dean of Tufts University,s Gerald J. ... Policy announced the 3rd Annual Friedman School Symposium, a ... facing industry, policy-makers, academics and thought leaders in the ... September 24th to 26th, 2008. , Fifteen experts will ...
... for Advanced Medical,Education (IAME) announces the release of ... program. Produced in response to a,strong demand by ... 3 CME,credits required for Mammography Center accreditation., ... course,available online at the CME Center of IAME,s ...
... 15 Percent Increase in Prescription Drug,Costs in ... HealthLeaders-InterStudy, NASHVILLE, Tenn., July 21 ... intelligence, reports that Excellus,BlueCross BlueShield will continue ... and public education efforts. According to the,new ...
... (SPI) has,received an R&D contract award from the ... drug candidate for hearing regeneration. SPI has,developed a ... inner ear of mammals involving p27Kip1, a cyclin ... division or proliferation in,many developing cells and tissues ...
Cached Medicine News:Health News:Lung Cancer Trial Targets Asbestos-Related Disease 2Health News:Embargoed Until Monday, July 21 at 5 p.m. EST; Scientists Figure Out How the Immune System and Brain Communicate to Control Disease 2Health News:Embargoed Until Monday, July 21 at 5 p.m. EST; Scientists Figure Out How the Immune System and Brain Communicate to Control Disease 3Health News:'Nutrition Agenda 2008' is focus of Tufts Friedman School Symposium 2Health News:'Nutrition Agenda 2008' is focus of Tufts Friedman School Symposium 3Health News:New York's Excellus BlueCross BlueShield to Continue Generic Medication Promotion to Help Control Costs 2Health News:Sound Pharmaceuticals Receives Additional DoD Funding for Its Hearing Regeneration Product 2
(Date:9/16/2014)... EHE International, the recognized leader in preventive medicine and annual ... David Abrams M.D . in Tarzana, CA ... Through David Abrams M.D ., EHE members in the ... to EHE,s preventive care programs to help proactively maintain their ... Abrams M.D. to its growing private provider network. With Dr. ...
(Date:9/16/2014)... 16, 2014  Decision Resources Group finds that the rheumatoid arthritis ... 2013 to over $18.2 billion in 2023 in the ... Germany , Italy , Spain ... Japan . TNF-alpha inhibitors will remain the leading drug ... but growth will be constrained and patient shares will decline due ...
(Date:9/16/2014)... DUBLIN , Sept. 16, 2014 ... addition of the "Global Laparoscopy Devices Industry ... The Global Laparoscopy Devices Industry Report ... the current state of the global laparoscopic devices. ... of the industry including definitions, classifications, applications and ...
Breaking Medicine Technology:EHE International Certifies David Abrams M.D. as Its Newest Partner 2The Rheumatoid Arthritis Drug Market Will Grow to $18.2 Billion in 2023, Driven by the Uptake of Oral Jak Inhibitors and Non TNF-alpha Biologics 2The Rheumatoid Arthritis Drug Market Will Grow to $18.2 Billion in 2023, Driven by the Uptake of Oral Jak Inhibitors and Non TNF-alpha Biologics 3Global Laparoscopy Devices Industry Report 2014 2
the LabOne Healthcare Group markets laboratory testing to physicians, patients, managed care companies, self-insured employers, wellness companies and hospitals....
... ideal hemostatic gauze for a variety of inpatient ... iX is easy to handle and can be ... sites that are often a challenge faced by ... used to control bleeding in outpatient procedures such ...
Sharp tipped straight scissors. For cutting in the iris plane or cutting peripheral membranes. May also be useful in ROP cases....
Microscissors : Horizontal Scissors...
Medicine Products: