Navigation Links
A key step toward a safer strep vaccine
Date:6/11/2014

triggering production of heart-damaging antibodies in some patients. Nizet said the latest findings corroborate this model, and suggest that eliminating the pathogen's ability to add GlcNAc sugars to GAC could be the basis for a safe vaccine.

"In this study, we discovered the strep genes responsible for the biosynthesis and assembly of GAC, the very molecule that defines the pathogen in clinical diagnosis," said first author Nina van Sorge, PharmD, PhD, a former postdoctoral fellow at UC San Diego who now leads her own laboratory at Utrecht University Medical Center in the Netherlands. "This discovery allowed us to generate mutant bacterial strains and study the contribution of GAC to strep disease."

The researchers found that a mutant strep strain lacking the human-like GlcNAc sugar on the GAC molecule exhibited normal bacterial growth and expressed key proteins known to be associated with strep virulence, but was easily killed when exposed to human white blood cells or serum. The mutant strep bacteria also lost the ability to produce severe disease in animal infection models

"Our studies showed that the GlcNAc sugar of GAC is a critical virulence factor allowing strep to spread in the blood and tissues," van Sorge said. "This is likely important for the rare, but deadly, complications of strep infection such as pneumonia, necrotizing fasciitis and toxic shock syndrome."

The researchers also identified a way to remove the problematic GlcNAc sugar so that a mutant form of the bacteria with only rhamnose-containing GAC could be purified and tested as a vaccine antigen.

"We showed that antibodies produced against mutant GAC antigen helped human white blood cells kill the pathogen and protected mice from lethal strep infection," said Jason Cole, PhD, a visiting project scientist from the University of Queensland, Australia, and co-lead author of the paper. "Because GAC is present in all strep strains, this may represent a
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Toward 24-7 glucose monitoring to help manage diabetes
2. GW Cancer Institute conducts survey on moving toward quality patient-centered care
3. Early steps toward personalized fitness: Interval training may benefit men more than women
4. Experimental trial represents promising step toward universal antidote for snakebite
5. Multimillion-dollar grant propels lab toward HIV cure
6. Toward unraveling the Alzheimers mystery
7. MSU physicists push new Parkinsons treatment toward clinical trials
8. Autism Speaks study finds advances towards universal early screening
9. Toward fixing damaged hearts through tissue engineering
10. A Priceless Resolution: Take That First Step Toward Financial Security
11. Athletes “Toward Injury Prevention in Sports” TIPS Gets Going in Las Vegas
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A key step toward a safer strep vaccine
(Date:8/23/2014)... (PRWEB) August 23, 2014 Youth substance ... Texas. It’s no different in Houston, TX. Substance abuse ... falling victim to drug and alcohol dependency in higher ... looking to beat substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
(Date:8/23/2014)... 23, 2014 Teen substance abuse ranks as ... Holly Springs, NC. Countless adolescents throughout North Carolina struggle with ... Unfortunately, many never receive professional rehab due to a lack ... to get help. Troubled Teens Holly Springs is a helpline ... local teenage alcohol abusers in Wake County who ...
(Date:8/22/2014)... August 23, 2014 Search Engine ... the first page of search engines and get ... Hosting has recently compared many Linux hosting suppliers ... Bluehost are the most recommended Linux hosting suppliers ... and Europe to buy high quality Linux hosting ...
(Date:8/22/2014)... 2014 Deep Research Report on ... in-depth research report on the Glucose Meter market. ... Glucose Meter definition, classification, application, and industry chain ... covers the international market analysis, including domestic market ... environment & economic situation analysis. The report on ...
(Date:8/22/2014)... Recently, Skmen.com, an experienced supplier of ... bohemian dresses in its online store. Moreover, all these ... to 28% off. All the international clients can obtain ... 2014. , The company’s professional online workers update ... worldwide customers more the latest information about its new ...
Breaking Medicine News(10 mins):Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2Health News:New Helpline Provides Teen Drug & Alcohol Recovery Information in Holly Springs, NC 2Health News:Top10BestSEOHosting.com Announces Best Cheap Hosting Suppliers Of This Summer 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:Cheap Bohemian Dresses Unveiled by Experienced Supplier Skmen.com 2
... ACNE TREATMENT EMBRACES DIFFERENCES IN MEN,S,AND WOMEN,S SKIN BY ... TREATMENT SOLUTION, SUMMIT, N.J., Oct. 30 Here,s ... between men and women are no more than skin,deep. ... care product, each,gender will be able to address these ...
... DENVER, Oct. 30 Air Methods Corporation,(Nasdaq: AIRM ) announces the ... Webcast, When: November 6, 2008 @ 4:15 ... Live over the Internet -- Simply log ... address above., Contact: Christine Clarke ...
... common gene variations may be responsible for much of ... New research on the MYH9 geneand its implications for ... the African American populationwill be summarized in a press ... Nephrology,s 41st Annual Meeting and Scientific Exposition in Philadelphia, ...
... Many with Eating Disorders, PHOENIX, Oct. 30 ... disorders are worried about treatment and not,seeking the help ... help for an eating disorder can be very,serious because ... Wall, PhD, director of psychological services at Remuda Ranch,Programs ...
... - Expands Therapy to Broader Patient Population -, ... Inc.,(NYSE: HSP ), a global specialty pharmaceutical ... Food and Drug Administration (FDA),approved a new indication ... This approval allows for use of Precedex in,non-intubated ...
... on a wide range of patient treatment experiences ... and features of ... Altrazeal(TM) -, LAS VEGAS, Oct. 30 ULURU ... application of Altrazeal(TM) -,Transforming Powder Dressing were presented yesterday at a special session,of ...
Cached Medicine News:Health News:Finally ... A Chance for Both Men and Women to Take CTRL(TM) of Their Own Skin! 2Health News:Finally ... A Chance for Both Men and Women to Take CTRL(TM) of Their Own Skin! 3Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 2Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 3Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 4Health News:Remuda Ranch Reports Many Individuals With Eating Disorders Are Not Getting Help They Need 2Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 2Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 3Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 4Health News:ULURU Inc. Hosts Symposium on Altrazeal(TM) at the 23rd Annual Clinical Symposium on Advances in Skin & Wound Care 2Health News:ULURU Inc. Hosts Symposium on Altrazeal(TM) at the 23rd Annual Clinical Symposium on Advances in Skin & Wound Care 3
(Date:8/22/2014)... On Aug. 20, at its annual meeting in ... voted on and approved a delegate resolution opposing the ... Cannabis Corp., a leading Canadian licensed producer of medicinal ... The CMA is quite right to point out that ... material, including medicinal cannabis. While some patients, particularly those ...
(Date:8/22/2014)... Equity Research highlights Epizyme (Nasdaq: EPZM - Free Report ... PNRA - Free Report ) as the Bear of the Day. ... FOLD - Free Report ), Sanofi (NYSE: SNY - ... ). Here is a synopsis of all five stocks: ... The biotech bull market is far from over due to ...
(Date:8/22/2014)... , Aug. 22, 2014  Cannabis Science, Inc. ... formulation-based drug development and related consulting, is pleased ... international medical cannabis conference taking place at the ... , on October 22, 2014.  The multilingual ... such as researchers, health professionals, and patients, to ...
Breaking Medicine Technology:Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 2Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 3
... ARBOR, Mich., Nov. 9 Thomson Reuters ... a leading clinical surveillance solution that enables hospitals to ... improve clinical quality and reduce total cost of treatment. ... at no additional cost. , CareFocus 2.0 ...
... Nov. 9 Arcadia Resources, Inc. (NYSE Amex: ... care services under the Arcadia HealthCare(SM) brand, has appointed ... will replace Tres Lund who announced his resignation from ... http://www.newscom.com/cgi-bin/prnh/20091109/DE07521 ) , Goldsmith is the Daniel ...
Cached Medicine Technology:Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 2Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 3Arcadia Resources Names Stephen Goldsmith to Board of Directors 2Arcadia Resources Names Stephen Goldsmith to Board of Directors 3
PDA application providing a complete guide for the diagnosis and management of electrolyte disorders....
Information on diagnosis and management of 500 common or important medical and surgical disorders....
Product includes all 15 Lexi-Comps databases. Includes Lexi-drugs, the official reference of the American Pharmacists Association and the National Professional Society of Pharmacists....
... BD Safety Knife with BD Xstar Blade ... that protects the blade in prodedure and ... based on a grind-less process for manufacturing ... outstanding sharpness and consistency. The arch ...
Medicine Products: