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A high intake of certain dietary fats associated with lower live birth rates in IVF
Date:7/3/2012

Istanbul, 3 July 2012: Women with a higher intake of dietary saturated fats have fewer mature oocytes available for collection in IVF, according to results of a study from the Harvard School of Public Health funded by the US National Institutes of Health. The study investigated the effect of dietary fat (classified as total, saturated, monounsaturated, polyunsaturated, omega 6, omega 3 and trans) on a range of preclinical and clinical outcomes in women having IVF. Results showed that the intake of saturated fat was inversely related to the number of mature oocytes retrieved, while polyunsaturated fat consumption was inversely associated with early embryo quality.(1)

Dietary fat intake has been previously studied for its effect on reproductive health; for example, a high intake of trans-fats has been associated with ovulatory infertility (as in polycystic ovary syndrome) and miscarriage, while saturated fats have been related to lower sperm concentrations. But so far little has been known about the effect of dietary fat intake on the outcome of fertility treatment.

The results of this study were presented today at the annual meeting of ESHRE (European Society of Human Reproduction and Embryology) by Dr Jorge Chavarro, Assistant Professor of Nutrition and Epidemiology at Harvard School of Public Health, USA.

The study took place among 147 women having IVF at the Massachusetts General Hospital Fertility Center. Preclinical assessments included oocyte development, fertilisation, embryo quality and cleavage rate, while clinical outcomes (pregnancy, live birth) were recorded in all women who had embryo transfer. The women were also categorised into tertiles of fat intake, with outcomes compared in relation to the lowest tertile. Results were controlled for other sources of energy, infertility diagnosis, ovarian stimulation protocol, body mass index (BMI) and smoking status.

Following statistical analysis it was found that women with
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Contact: Christine Bauquis
christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

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