Navigation Links
A high-fat diet could promote the development of Alzheimer's
Date:10/28/2008

Quebec City, October 28, 2008A team of Universit Laval researchers has shown that the main neurological markers for Alzheimer's disease are exacerbated in the brains of mice fed a diet rich in animal fat and poor in omega-3s. Details of the studywhich suggests that diets typical of most industrialized countries promote the development of Alzheimer'sare outlined in the latest online edition of Neurobiology of Aging.

To demonstrate this, the team led by Frdric Calon used a type of transgenic mice that produce two proteins found in the brains of Alzheimer patientstau proteins, which prevent proper neuron functioning, and amyloid-beta, associated with the formation of senile plaques within the brains of afflicted patients.

The researchers fed transgenic and regular mice different diets for nine months, after which they compared the effects on the animals' brains.

The mice whose diet was poor in omega-3s and rich in fat (60% of consumed calories) showed amyloid-beta and tau protein concentrations respectively 8.7 and 1.5 times higher than the control group mice, whose food contained 7 times less fat. The high-fat diet also reduced drebrin protein levels in the brain, another characteristic of Alzheimer's disease.

"Metabolic changes induced by such a diet could affect the inflammatory response in the brain," suggests study co-author Carl Julien to explain the link between fat consumption and Alzheimer's.

In most Western countries, diets rich in saturated fats and poor in omega-3s are the norm. "Our findings lead us to believe that a diet containing more omega-3s and less saturated fat could prevent the development of Alzheimer's, at the very least among people genetically predisposed to the disease," comments Dr. Calon. "We cannot state with any certainty that what we have observed among transgenic mice also occurs in humans, but there is no harm in eating less fat and more omega-3s," concludes the researcher.


'/>"/>

Contact: Jean-Franois Hupp
jean-francois.huppe@dap.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Related medicine news :

1. High-fat diet makes mice susceptible to liver injury
2. High-Fat Diet Can Disrupt Bodys Clock
3. Study provides hope that some transplant patients could live free of antirejection drugs
4. Study provides hope that some transplant patients could live free of anti-rejection drugs
5. HIV denialists spread misinformation online -- consequences could be deadly; and more
6. Virus Could Help Drive Obesity
7. Discovery of sugar sensor in intestine could benefit diabetes
8. Cranberry Could Juice Up Ovarian Cancer Treatment
9. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
10. High-risk behaviors could lead to HIV epidemic in Afghanistan
11. Chinas 1-child policy could backfire on its elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
Breaking Medicine Technology: