Navigation Links
A glass apart
Date:6/5/2008

British scientists are developing a new type of glass that can dissolve and release calcium into the body. This will enable patients to regrow bones and could signal a move away from bone transplants.

The porous glass, originally developed at Imperial College is capable of acting as an active template for new bone growth, dissolving in the body without leaving any trace of itself or any toxic chemicals. As it dissolves it releases calcium and other elements such as silicon into the adjacent body fluids, stimulating bone growth.

The glass activates genes present in human bone cells which encode proteins controlling the bone cell cycle and the differentiation of the cell to form bone matrix and rapid mineralisation of bone nodules. It is the release of soluble silica and calcium ions in specific concentrations that activate the genes. Gene activation occurs only when the timing sequence of the cell cycle is matched by that of the glass surface reactions and controlled release of the ions.

Partners at the Universities of Kent and Warwick have been carrying out experiments at the Science and Technology Facilities Council's world leading ISIS neutron source. Research at ISIS is showing exactly how the calcium is held in the glass and thereby precisely how it is released into the body. Professor Bob Newport at the University of Kent explains that it was when the material was studied at ISIS that the process became clear.

"Although variants of these bioactive materials are already in clinical use, and the role of calcium in these materials was already understood as being critical in terms of both the stability of the glass and its bioactivity, no direct and quantitative study of the calcium atoms within the glass network had been undertaken. Using ISIS to study the relationship between these atoms and the host silicate glass via techniques unique to neutron diffraction has enabled us to move forward with the programme. The key outcome of our experiments has been a full understanding, at the level of atomic arrangements, of why it is that calcium is able so easily to leave the glass at the rate required to generate the desired response."

By comparing samples made with natural calcium and with a calcium isotope it was possible for the first time to isolate the complex and subtle contribution of the calcium from that of all the other atoms present. Dr Andrew Taylor, Director of the ISIS neutron source commented, "To allow people to remain active, and to contribute to society for longer, the need for new materials to replace and repair worn out and damaged tissues becomes ever more important. We're pleased that at ISIS we can continue to contribute to cutting edge research that affects all our lives."

Further research is planned at the ISIS Second Target Station when it opens later this year. This will investigate glass/polymer hybrids and could be instrumental in developing mechanically stronger versions of the glass that would be load bearing and available for medical use in the context of joint replacement. If the extensive research goes as expected, clinical trials could be in place in the next five years.


'/>"/>

Contact: Natalie Bealing
n.d.bealing@stfc.ac.uk
01-235-445-484
Science and Technology Facilities Council
Source:Eurekalert

Related medicine news :

1. ISS and Glass Lewis Recommend Cholestech Stockholders Vote FOR Merger
2. Glass Lewis Recommends Arrow Shareholders Vote on the White Proxy Card for Merger With Teleflex and for Current Board of Directors at Arrow Annual Meeting
3. Proxy Governance Joins ISS, Glass Lewis and Egan Jones in Recommending Arrow International Shareholders Vote to Approve the $45.50 Per Share Merger With Teleflex
4. Eyeglasses Upgrade Helps Elderly Battle Depression
5. Looking for a Healthy Alternative for Your Childrens Drinks? Try a Glass of Sun Shower(TM) 100% Nectarine Juice
6. Mythbusted -- people who wear glasses arent geeks
7. Study: Kids think eyeglasses make other kids look smart
8. Prism glasses expand the view for patients with hemianopia
9. Kids Think Glasses Make Others Look Smart, Honest
10. Daily Glass of Wine Cut Risk of Fatty Liver Disease
11. Just hours apart, 2 brothers undergo robotic prostate cancer surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... It's not always common knowledge whether ... illnesses that are unclear as to whether or not they are contagious, and most ... of these illnesses. So, FindaTopDoc took a look into the matter. , They ...
(Date:4/28/2017)... ... April 28, 2017 , ... Getting enough sleep affects much more than energy – it ... 19 hours without sleep can compromise motor reaction time, which can increase the risk of ... is sharing the following tips from the NSF to help you sleep better and feel ...
(Date:4/28/2017)... VA (PRWEB) , ... April 28, 2017 , ... The ... volunteer board members and officers for 2017-2018. The annual board election process has been ... on a volunteer basis. , Thomas C. Dickerson, Ed.D., FACHE, succeeds Jim Hamilton, MHA, ...
(Date:4/28/2017)... National Harbor, Md. (PRWEB) , ... April 28, ... ... Urgent Care Association of America (UCAOA) and College of Urgent Care Medicine will ... Momentum 2017 workshops, sessions and speakers will help those in the industry adapt ...
(Date:4/28/2017)... ... April 28, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... the Creator responds to and which He does not. Yisrayl says with so many ... is the true name, but he says with a little Scripture, backed with a lot ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... N.J. , April 19, 2017  Novartis ... by the National Heart, Lung, and Blood Institute ... demonstrating that 58% of patients with treatment-naïve severe ... months when treated with eltrombopag at the initiation ... . The study evaluated three sequential treatment groups, ...
(Date:4/18/2017)... 2017 Cogentix Medical, Inc. (NASDAQ: CGNT), a ... Uro/Gyn and Gynecology markets with innovative and proprietary products, ... March 31, 2017 after the market close on Tuesday, ... host a conference call and webcast to discuss its ... 2017 at 4:30 p.m. Eastern Time (3:30 p.m. Central ...
(Date:4/18/2017)... 2017  Astute Medical, Inc., developer of biomarkers for ... presented at the 2017 National Kidney Foundation (NKF) ... through April 22. Physicians will present data on two ... risk for acute kidney injury (AKI) during the management ... Elevated levels of TIMP-2 and IGFBP-7 have ...
Breaking Medicine Technology: