Navigation Links
A glass apart
Date:6/5/2008

British scientists are developing a new type of glass that can dissolve and release calcium into the body. This will enable patients to regrow bones and could signal a move away from bone transplants.

The porous glass, originally developed at Imperial College is capable of acting as an active template for new bone growth, dissolving in the body without leaving any trace of itself or any toxic chemicals. As it dissolves it releases calcium and other elements such as silicon into the adjacent body fluids, stimulating bone growth.

The glass activates genes present in human bone cells which encode proteins controlling the bone cell cycle and the differentiation of the cell to form bone matrix and rapid mineralisation of bone nodules. It is the release of soluble silica and calcium ions in specific concentrations that activate the genes. Gene activation occurs only when the timing sequence of the cell cycle is matched by that of the glass surface reactions and controlled release of the ions.

Partners at the Universities of Kent and Warwick have been carrying out experiments at the Science and Technology Facilities Council's world leading ISIS neutron source. Research at ISIS is showing exactly how the calcium is held in the glass and thereby precisely how it is released into the body. Professor Bob Newport at the University of Kent explains that it was when the material was studied at ISIS that the process became clear.

"Although variants of these bioactive materials are already in clinical use, and the role of calcium in these materials was already understood as being critical in terms of both the stability of the glass and its bioactivity, no direct and quantitative study of the calcium atoms within the glass network had been undertaken. Using ISIS to study the relationship between these atoms and the host silicate glass via techniques unique to neutron diffraction has enabled us to move forward with the programme. The key outcome of our experiments has been a full understanding, at the level of atomic arrangements, of why it is that calcium is able so easily to leave the glass at the rate required to generate the desired response."

By comparing samples made with natural calcium and with a calcium isotope it was possible for the first time to isolate the complex and subtle contribution of the calcium from that of all the other atoms present. Dr Andrew Taylor, Director of the ISIS neutron source commented, "To allow people to remain active, and to contribute to society for longer, the need for new materials to replace and repair worn out and damaged tissues becomes ever more important. We're pleased that at ISIS we can continue to contribute to cutting edge research that affects all our lives."

Further research is planned at the ISIS Second Target Station when it opens later this year. This will investigate glass/polymer hybrids and could be instrumental in developing mechanically stronger versions of the glass that would be load bearing and available for medical use in the context of joint replacement. If the extensive research goes as expected, clinical trials could be in place in the next five years.


'/>"/>

Contact: Natalie Bealing
n.d.bealing@stfc.ac.uk
01-235-445-484
Science and Technology Facilities Council
Source:Eurekalert

Related medicine news :

1. ISS and Glass Lewis Recommend Cholestech Stockholders Vote FOR Merger
2. Glass Lewis Recommends Arrow Shareholders Vote on the White Proxy Card for Merger With Teleflex and for Current Board of Directors at Arrow Annual Meeting
3. Proxy Governance Joins ISS, Glass Lewis and Egan Jones in Recommending Arrow International Shareholders Vote to Approve the $45.50 Per Share Merger With Teleflex
4. Eyeglasses Upgrade Helps Elderly Battle Depression
5. Looking for a Healthy Alternative for Your Childrens Drinks? Try a Glass of Sun Shower(TM) 100% Nectarine Juice
6. Mythbusted -- people who wear glasses arent geeks
7. Study: Kids think eyeglasses make other kids look smart
8. Prism glasses expand the view for patients with hemianopia
9. Kids Think Glasses Make Others Look Smart, Honest
10. Daily Glass of Wine Cut Risk of Fatty Liver Disease
11. Just hours apart, 2 brothers undergo robotic prostate cancer surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... ... software solution, iCode Assurance, at HCCA’s 21st annual Compliance Institute on March 26-28 ... coding audit process for all medical chart types with a comprehensive set of ...
(Date:3/23/2017)... ... ... Journey Through Heaven”: the true-life account of a man who faced death and emerged ... for His people. “My Journey Through Heaven” is the creation of published author Earl ... grandchildren living and doing for God as best they can. , Published by Christian ...
(Date:3/23/2017)... ... ... simple and strong explanation of the God’s love. “More Corruption” is the creation of published ... to write a book about Him. , She says, “I’m fed up with mortals misjudging ... Lord God. They have not walked in my shoes and I know they never could ...
(Date:3/22/2017)... ... March 23, 2017 , ... Catalent Pharma Solutions, the ... and consumer health products, today announced that it had won the ‘Clinical Supply ... the Suntec Singapore International Exhibition & Convention Centre, Singapore. The award was presented ...
(Date:3/22/2017)... ... , ... Old School Labs™, makers of the best-selling Vintage line of natural ... Theophane, who trained with Floyd Mayweather, made his professional debut in London in 2003 ... impressive number of wins in contests in Britain, Germany and the U.S. , ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... Sweden , Mar 23, 2017 ... medicine company, today announced that the English version of the ... website www.neurovive.com .  ... About NeuroVive NeuroVive Pharmaceutical AB ... to the discovery and development of medicines that preserve mitochondrial ...
(Date:3/22/2017)... DUBLIN , Mar. 22, 2017 Research ... Care Devices Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 10.9% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... 22, 2017 Under the impetus of ... market size increased year by year at the ... 2021, the market size will maintain the growth ... outnumber RMB140 billion in 2021, thanks to severe ... of biological agents and supporting policies. At ...
Breaking Medicine Technology: