Navigation Links
A glass apart

British scientists are developing a new type of glass that can dissolve and release calcium into the body. This will enable patients to regrow bones and could signal a move away from bone transplants.

The porous glass, originally developed at Imperial College is capable of acting as an active template for new bone growth, dissolving in the body without leaving any trace of itself or any toxic chemicals. As it dissolves it releases calcium and other elements such as silicon into the adjacent body fluids, stimulating bone growth.

The glass activates genes present in human bone cells which encode proteins controlling the bone cell cycle and the differentiation of the cell to form bone matrix and rapid mineralisation of bone nodules. It is the release of soluble silica and calcium ions in specific concentrations that activate the genes. Gene activation occurs only when the timing sequence of the cell cycle is matched by that of the glass surface reactions and controlled release of the ions.

Partners at the Universities of Kent and Warwick have been carrying out experiments at the Science and Technology Facilities Council's world leading ISIS neutron source. Research at ISIS is showing exactly how the calcium is held in the glass and thereby precisely how it is released into the body. Professor Bob Newport at the University of Kent explains that it was when the material was studied at ISIS that the process became clear.

"Although variants of these bioactive materials are already in clinical use, and the role of calcium in these materials was already understood as being critical in terms of both the stability of the glass and its bioactivity, no direct and quantitative study of the calcium atoms within the glass network had been undertaken. Using ISIS to study the relationship between these atoms and the host silicate glass via techniques unique to neutron diffraction has enabled us to move forward with the programme. The key outcome of our experiments has been a full understanding, at the level of atomic arrangements, of why it is that calcium is able so easily to leave the glass at the rate required to generate the desired response."

By comparing samples made with natural calcium and with a calcium isotope it was possible for the first time to isolate the complex and subtle contribution of the calcium from that of all the other atoms present. Dr Andrew Taylor, Director of the ISIS neutron source commented, "To allow people to remain active, and to contribute to society for longer, the need for new materials to replace and repair worn out and damaged tissues becomes ever more important. We're pleased that at ISIS we can continue to contribute to cutting edge research that affects all our lives."

Further research is planned at the ISIS Second Target Station when it opens later this year. This will investigate glass/polymer hybrids and could be instrumental in developing mechanically stronger versions of the glass that would be load bearing and available for medical use in the context of joint replacement. If the extensive research goes as expected, clinical trials could be in place in the next five years.


Contact: Natalie Bealing
Science and Technology Facilities Council

Related medicine news :

1. ISS and Glass Lewis Recommend Cholestech Stockholders Vote FOR Merger
2. Glass Lewis Recommends Arrow Shareholders Vote on the White Proxy Card for Merger With Teleflex and for Current Board of Directors at Arrow Annual Meeting
3. Proxy Governance Joins ISS, Glass Lewis and Egan Jones in Recommending Arrow International Shareholders Vote to Approve the $45.50 Per Share Merger With Teleflex
4. Eyeglasses Upgrade Helps Elderly Battle Depression
5. Looking for a Healthy Alternative for Your Childrens Drinks? Try a Glass of Sun Shower(TM) 100% Nectarine Juice
6. Mythbusted -- people who wear glasses arent geeks
7. Study: Kids think eyeglasses make other kids look smart
8. Prism glasses expand the view for patients with hemianopia
9. Kids Think Glasses Make Others Look Smart, Honest
10. Daily Glass of Wine Cut Risk of Fatty Liver Disease
11. Just hours apart, 2 brothers undergo robotic prostate cancer surgery
Post Your Comments:
(Date:6/26/2016)... ... ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center for ... Table in Battle Creek, MI, where the rehabilitation facility is located. This annual celebration ... world’s leading providers of cereal and other breakfast foods. Its residents often refer to ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Guerbet announced today that it has been named a ... One of 12 suppliers to receive the ... of Premier members through exceptional local customer service and ... lower costs. "We ... customer service from Premier," says Massimo Carrara , ...
(Date:6/23/2016)... , June 23, 2016 ... "Surgical Procedure Volumes: Global Analysis (United States, China, ... Canada)" report to their offering. ... essential tool for healthcare business planners, provides surgical procedure ... at surgery trends with an in-depth analysis of growth ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... rough waters, but it continues to present great opportunities ... featured companies for today: Intrexon Corp. (NYSE: ... ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... Learn more about these stocks and receive your complimentary ...
Breaking Medicine Technology: