Navigation Links
A gimmick-free weight-loss pill in the works
Date:1/26/2010

Montreal, January 26, 2010 A Universit de Montral research team is developing a pill composed of leptin, the protein that tells our brain to stop eating. "Mice deprived of leptin will not stop eating. They become so big they have trouble moving around," says Mose Bendayan, a pathology professor at the Universit de Montral Faculty of Medicine who has studied the leptin protein extensively.

Leptin regulates appetite in mammals and its levels decrease when fasting and rise during meals. It has been proven to be an appetite suppressant when administered intravenously to pathologically obese people.

Postdoctoral student Philippe Cammisotto is leading the charge for a leptin-based, appetite suppressing pill with Dr. Bendayan and mile Levy, a professor from the Department of Nutrition. "Taken orally, such a pill would provide obese people with the sensation of being full. They would eat less and in turn lose weight," says Dr. Cammisotto.

"We hope to start animal testing in 2010," says Bendayan. "The molecule is easy to synthesize and the protocol is ready."

After decades of building his reputation in fundamental research, Bendayan is happy to collaborate on something more tangible. "Obesity is a big problem in our society, no pun intended," says Bendayan. "To develop medication to combat obesity would be a great way for our laboratory to contribute to public health."

The new pill is being created based on a startling Universit de Montral discovery from 2006: leptin isn't only secreted by fatty tissues. "From the first bite of any meal, leptin levels skyrocket in the bloodstream. Yet this has nothing to do with the leptin stored in the fatty tissues," says Bendayan. "In the lab, we proved that up to 80 percent of cells in our stomach also produce leptin. Those are the ones that regulate appetite."

The Universit de Montral finding led to a different understanding of how the protein works, since leptin alone can't survive in an acidic stomach without assistance. Indeed, leptin protects itself with an accomplice that acts as its bodyguard and accompanies the protein through the digestive system until it can be absorbed into the bloodstream.


'/>"/>

Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. Weight-Loss Surgeries Extend Lives
2. UMass Medical School study identifies the best weight-loss plans for heart health
3. FTC Attacks Infomercial Marketer to Silence Best-Selling Authors Weight-Loss Tips
4. Psychiatric Woes Can Postpone Weight-Loss Surgery
5. Studies Examine Life After Weight-Loss Surgery
6. NutriSystem Advances Weight-Loss Category
7. New Weight-Loss Drug Shows Promise in Early Study
8. USA TODAY Weight-Loss Challenge Returns For 5th Year With Eight Weeks of Compelling Stories and Online Features
9. Some Weight-Loss Drugs Might Disrupt Brain Growth in Kids
10. Weight-Loss Aids Bought on Internet Might Harm Your Heart
11. Weight-Loss Surgery Weighed as Diabetes Rx
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... California (PRWEB) , ... June ... ... pioneer in the patient payment industry today announced its strategic partnership with ... health system workflows. , The two companies’ proven, proprietary technology combine to ...
(Date:6/26/2016)... Viejo, California (PRWEB) , ... June 26, 2016 , ... ... Final Cut Pro X. , "Film editors can give their videos a whole new ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Research and Markets ... Electronics 2015-2025: Applications, Technologies, Forecasts" report to ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, Composite ... Structural electronics involves electronic and/or electrical components and ... dumb structures such as vehicle bodies or conformally ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American Respiratory ... testing company, is now able to perform sophisticated lung assessments in ... Medical Technologies , Inc. Patients are no longer ... to ndd,s EasyOne PRO ® , ARL patients like Jeanne R. ... testing done in the comfort of her own home. ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
Breaking Medicine Technology: