Navigation Links
A genetic defect in sex cells may predispose to childhood leukemia
Date:12/17/2012

This press release is available in French.

Researchers at the Sainte-Justine University Hospital Center and the University of Montreal have found a possible heredity mechanism that predisposes children to acute lymphoblastic leukemia (ALL), the most common type of blood cancer in children. According to their findings published in Genome Research, the presence of a genetic defect in the egg or sperm from which children having ALL arise may be a prerequisite for the disease to develop. A significant number of children with ALL are thought to inherit a rare PRDM9 gene variant responsible for the abnormal sex cellsa gene variant that puts their own children at risk of having ALL-predisposed offspring.

"Our findings indicate ALL susceptibility to be partially hereditary. However, it is not classic heredity in the sense that the abnormal genetic variant does not need to be passed from parent to child for offspring to have the disease," explains Julie Hussin, a doctoral student in Genomics under the direction of Dr. Philip Awadalla, a genetics researcher.

"Instead, the genetic defect in the egg or sperm from which the children developed is thought to predispose them to leukemia," continues Julie Hussin. "However, only the children who inherit the genetic variant run the risk of transmitting ALL predispositions to their offspring." According to the study, more than three fourth of families with affected children have an atypical form of the PRDM9 gene, but only half the patients inherited this genetic variant. The defect is expressed by chromosome recombinations at unusual points during gamete formation (eggs in girls, sperm in boys).

While an abnormal gamete may lead to ALL development, this condition alone is not enough. "Triggering the process of cancer cell proliferation inevitably requires a second hit, such as other mutations or environmental factors," explains Julie Hussin.

Until now, few pediatric cancer studies have analyzed data from parents, as scientists generally focus on studying children, their tumors or their environment, especially during pregnancy. "Parents have to be included in these studies. Our findings demonstrate the importance of including parents' genetic information for the understanding of childhood leukemia, as well as other early childhood diseases," added Dr. Philip Awadalla, the lead principal investigator on the study.

The findings were replicated in a cohort of American children with ALL through a collaboration of the Sainte-Justine University Hospital Center in Montreal, Canada, and St. Jude Children's Research Hospital in Memphis, USA.

Acute Lymphoblastic Leukemia Model of Heredity

At least one parent with/without leukemia produces abnormal gametes and carries a rare PRDM9 allele

Two Children
Both have leukemia, since each develops from an abnormal gamete

Child 1
Receives the rare allele in its genome
Produces abnormal gametes
Risks having children with leukemia

Child 2
Does not receive the rare allele
Produces normal gametes
Does not risk having children with leukemia


'/>"/>
Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
2. Drug resistant leukemia stem cells may be source of genetic chaos, Temple scientists find
3. Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
4. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
5. New genetic disorder of balance and cognition discovered
6. Unlocking the genetic mysteries behind stillbirth
7. New evidence for epigenetic effects of diet on healthy aging
8. Genetic data shows that skin cancer risk includes more than UV exposure
9. Genetics Society of Americas Genetics journal highlights for December 2012
10. McKinney Orthodontics Educates on New Evidence that Crooked Teeth are Genetic
11. Genetic factor holds key to blood vessel health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... ... LaserShip, a regional parcel carrier that services the eastern U.S., donated and delivered ... order to aid in the Flint water crisis. In 2014, LaserShip acquired Prestige Delivery ... only 15 miles away from Flint. , “We have deep roots in the local ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... unveiling its revolutionary new 2.0 version at the International Roofing Expo in Orlando, ... power of the world's most advanced weather technology in the hands of consumers, ...
(Date:2/10/2016)... NASHVILLE, Tenn. (PRWEB) , ... February 10, 2016 ... ... by the American Academy of Emergency Medicine , an emergency medicine ... of practice management services . , The American Academy of Emergency Medicine, ...
(Date:2/10/2016)... ... 2016 , ... Emergency rooms provide emergency care to stabilize critical health issues, ... with dental emergencies at risk of losing a tooth or their smiles. Dr. Marine ... Common dental emergencies include:, , Avulsed or knocked-out teeth , ...
(Date:2/10/2016)... CO (PRWEB) , ... February 10, 2016 , ... Dr. ... announce the practice is now accepting new dental patients and families in the North ... exceptional dental care services from cleanings to cosmetic dentistry, and all in the most ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , February 10, 2016 Puerto ... --> Puerto Rico Healthcare and Life Sciences Report 2016 ... 61 page Puerto Rico Healthcare and Life Sciences Report ... insights into the fifth largest territory in the world for ... medical device and diagnostics manufacturing, and more universities per square ...
(Date:2/10/2016)... 10, 2016 CERS ), Medivation, Inc. ... ) and Celldex Therapeutics, Inc. (NASDAQ: CLDX ). ... Adamas Pharmaceuticals, Inc. (NASDAQ: ADMS ) and Celldex Therapeutics, ... Orphan Drug Designations become vitally important in the development of ... drugs and biologics which are defined as those intended for ...
(Date:2/10/2016)... ALBANY, New York , February 10, 2016 ... Share, Growth, Trends and Forecast 2015 - 2023 ", reveals ... a rather slow growth from 2015 to 2023 owing to ... register a meager CAGR of 1.30% during the forecast period, ... 2014 to US$38.9 bn in 2023. --> Antibacterial ...
Breaking Medicine Technology: