Navigation Links
A further step towards preventing diabetes
Date:7/26/2012

Pancreatic beta cells produce insulin, responsible for controlling blood sugar levels and thus essential for our survival. Among the numerous factors that affect the workings of these cells, a protein called Cx36 was identified a few months ago by a research team at the UNIGE. The scientists there had demonstrated that in transgenic mice, suitably modified so as not to produce any Cx36, synchronization of the beta cells ceased and insulin production went out of control. This de-synchronization of insulin secretion is the first measurable sign in people suspected of developing type 2 diabetes. Armed with this knowledge, the research team have set about finding molecules which act directly on Cx36 with the objective of developing a novel therapeutic approach to fighting diabetes.

Paolo Meda, Professor of Cellular Physiology and Metabolism in the University of Geneva's Faculty of Medicine, has set his team a real challenge - study the protein Cx36, present in minute quantities and almost impossible to detect using traditional techniques, and which has a half-life of around three hours!

Over one thousand drugs tested

Sabine Bavamian and Helena Pontes, researchers in Professor Meda's laboratory, set to work on developing a non-invasive system for understanding how Cx36 works. This project has been partly financed by the Juvenile Diabetes Research Foundation (USA) and the Swiss National Science Foundation and is using equipment in the Bio-Imaging department of UNIGE's Faculty of Medicine. The two scientists have been able to develop a new model using living cells which produce insulin and Cx36 in culture in order to be able rapidly to test a large number of potentially interesting molecules. With this novel approach, they have been able to analyse some 1040 molecules, enabling them to identify those that stimulate insulin production and those that inhibit it. Such discoveries should enable the roll out of new pharmacological treatment strate
'/>"/>

Contact: Paolo Meda
paolo.meda@unige.ch
0041-793-532-215
Universit de Genve
Source:Eurekalert

Page: 1 2

Related medicine news :

1. LaStone Launches Merger with TIR Massage Stone To Further The Advancement of Massage Therapy Education in 2012
2. Hospitals for Poor May Struggle Further Under Health Care Reform
3. Environment key to preventing childhood disabilities
4. Preventing post-traumatic stress
5. A systems approach to preventing obesity in early life
6. Antiretroviral treatment for preventing HIV infection: an evidence review for physicians
7. Safe, simple eye test may help save lives by preventing stroke
8. Echocardiogram screenings are effective in preventing rheumatic heart disease
9. Preventing or better managing diabetes may prevent cognitive decline, according to UCSF study
10. Preventing Oral Diseases Begins in Pregnancy Claims Author in New eBook
11. U.S. High Schools Lax in Preventing Dating Abuse: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Scientists have identified the first genetic variant specifically ... sub-type accounting for around 10-15 per cent of ... study of the breast cancer sub-type, called invasive ... genetic causes of this particular kind of breast ... The research, published today (Thursday) in the journal ...
(Date:4/17/2014)... Researchers at the University of California, San Diego School ... those who have suffered a recent major loss are ... older adults. , The study is published in this ... Psychiatry . , Because compassionate behaviors are associated with ... findings offer insights into ways to improve the outcomes ...
(Date:4/17/2014)... April 17, 2014U.S. military personnel who served in ... concussive traumatic brain injury (TBI) were compared to ... other medical reasons. Differences in measures of overall ... months after injury are reported in an article ... journal from Mary Ann Liebert, Inc., publishers. The ...
(Date:4/17/2014)... 2014 By discovering a new mechanism that allows ... researchers at UC Irvine and the Salk Institute have ... or prevent stroke-induced brain damage. , A complex and ... death and primary reason for disability in the U.S. ... and lets blood-borne material into the brain, causing the ...
(Date:4/17/2014)... Cesar A. Arias, M.D., Ph.D., at The University of ... a new superbug that caused a bloodstream infection in ... 17 issue of The New England Journal of ... a class of highly-resistant bacteria known as methicillin-resistant ... cause of hospital and community-associated infections. The superbug has ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:The ilk of human kindness 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:New MRSA superbug emerges in Brazil 2
... Forces with The American Diabetes Association to Raise Awareness ... March 24 In observance of American Diabetes Alert ... and fitness, is reaffirming its commitment to "Fighting Diabetes ... the American Diabetes Association to offer the public a ...
... Outstanding Cellegy Common Stock Expected to be Approximately 1: ... Bulletin Board: CLGY) today announced that the stockholders of ... announced merger of the two companies at stockholder meetings ... is subject to customary closing conditions, is expected to ...
... Document Capture, Streamlines Health Records DocumentationDALLAS, March ... leading developer of healthcare software solutions for ... with Imagetek, a national leader in enterprise ... strengthen the capture of paper-based documents and ...
... on orthopedic spend , ... Dallas (Vocus) March 24, ... its supply chain relationship with Broadlane. Wuesthoff will continue to ... and purchased services to help manage its approximate $53 million in ...
... CapabilitiesSAN DIEGO, March 24 Crossflo Systems, Inc., ... an innovative provider of data-sharing solutions for the ... implementing a data sharing system for a Health ... Montana. The Crossflo DataExchange(R) Server software (CDX), ...
... Derma Sciences, Inc. (OTC Bulletin Board: DSCI), ... it will report its fourth quarter and year-end 2008 results ... a conference call that same day to discuss the results ... or 617-213-8893 (international), with passcode 42480759 to access the call. ...
Cached Medicine News:Health News:Gold's Gym Offers Free Exercise Guide to Support American Diabetes Alert Day(R) 2Health News:Cellegy and Adamis Stockholders Approve Merger Transaction and Related Proposals 2Health News:Cellegy and Adamis Stockholders Approve Merger Transaction and Related Proposals 3Health News:iMedica and Imagetek Team Up to Ease Transition to Paperless Medical Practice 2Health News:iMedica and Imagetek Team Up to Ease Transition to Paperless Medical Practice 3Health News:iMedica and Imagetek Team Up to Ease Transition to Paperless Medical Practice 4Health News:Wuesthoff Health System and Broadlane Continue Exclusive Relationship; Orthopedic Consulting Initiative Yields Significant Savings 2Health News:Wuesthoff Health System and Broadlane Continue Exclusive Relationship; Orthopedic Consulting Initiative Yields Significant Savings 3Health News:Wuesthoff Health System and Broadlane Continue Exclusive Relationship; Orthopedic Consulting Initiative Yields Significant Savings 4Health News:Crossflo Provides Data Sharing for Montana Health Information Exchange 2Health News:Crossflo Provides Data Sharing for Montana Health Information Exchange 3Health News:Derma Sciences to Report 2008 Fourth Quarter and Year-End Results on April 1, 2009 2
(Date:1/15/2014)... 15, 2014 MultiCell Technologies, Inc. (OTC Bulletin Board: ... patent application concerning composition of matter, biological targets, mechanism ... cell death.  This patent application describes ... RNA molecules (VSRNAs) which interfere with the basic homeostatic ...
(Date:1/15/2014)... GENEVA, Ill. , Jan. 15, 2014 The ... a Medical Fitness Center by the Medical Fitness Association, ... centers to achieve their full potential. The Cadence Fitness ... in the western suburbs and second in the Chicagoland ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com ... is available in its catalogue: ... – Worldwide Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Analysis Insulin Pumps ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
... 8, 2011 As the economy recovery continues to ... competition and reduce health care costs. Running counter to ... that takes away employers, ability to save money by ... the Pharmaceutical Care Management Association (PCMA) said today. ...
... N.J., July 8, 2011 BD (Becton, Dickinson and Company) ... conduct a live webcast of its third fiscal quarter 2011 ... 9:00 a.m. (ET).  BD will issue a press release detailing ... of the conference call, along with related slides, will be ...
Cached Medicine Technology:As Economic Recovery Sputters, Independent Drugstores Shouldn't Shoulder Employers With Higher Costs 2
... Revision Knee System features ... femoral replacement options. The centerpiece ... Rotating Hinge Knee, promotes the ... and is designed for distribution ...
The Advance stemmed medial-pivot knee is a revision knee that provides unique and competitive features....
... LCCK Femoral Component is intended for ... due to inadequate mediolateral, anteroposterior and ... and/or stem extensions due to inadequate ... available with a non-coated fixation surface. ...
The Duracon system provides superb articular conformity throughout the range of motion, reducing contact stresses generally associated with wear....
Medicine Products: