Navigation Links
A further step towards preventing diabetes
Date:7/26/2012

Pancreatic beta cells produce insulin, responsible for controlling blood sugar levels and thus essential for our survival. Among the numerous factors that affect the workings of these cells, a protein called Cx36 was identified a few months ago by a research team at the UNIGE. The scientists there had demonstrated that in transgenic mice, suitably modified so as not to produce any Cx36, synchronization of the beta cells ceased and insulin production went out of control. This de-synchronization of insulin secretion is the first measurable sign in people suspected of developing type 2 diabetes. Armed with this knowledge, the research team have set about finding molecules which act directly on Cx36 with the objective of developing a novel therapeutic approach to fighting diabetes.

Paolo Meda, Professor of Cellular Physiology and Metabolism in the University of Geneva's Faculty of Medicine, has set his team a real challenge - study the protein Cx36, present in minute quantities and almost impossible to detect using traditional techniques, and which has a half-life of around three hours!

Over one thousand drugs tested

Sabine Bavamian and Helena Pontes, researchers in Professor Meda's laboratory, set to work on developing a non-invasive system for understanding how Cx36 works. This project has been partly financed by the Juvenile Diabetes Research Foundation (USA) and the Swiss National Science Foundation and is using equipment in the Bio-Imaging department of UNIGE's Faculty of Medicine. The two scientists have been able to develop a new model using living cells which produce insulin and Cx36 in culture in order to be able rapidly to test a large number of potentially interesting molecules. With this novel approach, they have been able to analyse some 1040 molecules, enabling them to identify those that stimulate insulin production and those that inhibit it. Such discoveries should enable the roll out of new pharmacological treatment strategies for type 2 diabetes.

And what if animal venoms are not poisons after all?

Although there is now a large number of drugs that are prescribed for diabetics the world over to help alleviate insulin secretion de-synchronization, the majority of them have unfortunate side effects. And thus Professor Meda has decided to use the innovative technique developed by his team to test the effect on Cx36 of very different molecules, produced from animal venom. Such molecules should not give rise to the same type of problem posed by the traditional drugs used currently. The screening, or selection, of the venom should enable carrying out the necessary validation tests, initially in vitro, and then in vivo. We have some 3 to 5 years work ahead of us, but we have very serious hopes of discovering molecules which act exclusively on Cx36, unlike all the currently identified molecules, with a view to limiting side-effects, explains Professor Meda. In the fight against diabetes, scientists are exploring numerous avenues, some of which are rather surprising.


'/>"/>
Contact: Paolo Meda
paolo.meda@unige.ch
0041-793-532-215
Universit de Genve
Source:Eurekalert

Related medicine news :

1. LaStone Launches Merger with TIR Massage Stone To Further The Advancement of Massage Therapy Education in 2012
2. Hospitals for Poor May Struggle Further Under Health Care Reform
3. Environment key to preventing childhood disabilities
4. Preventing post-traumatic stress
5. A systems approach to preventing obesity in early life
6. Antiretroviral treatment for preventing HIV infection: an evidence review for physicians
7. Safe, simple eye test may help save lives by preventing stroke
8. Echocardiogram screenings are effective in preventing rheumatic heart disease
9. Preventing or better managing diabetes may prevent cognitive decline, according to UCSF study
10. Preventing Oral Diseases Begins in Pregnancy Claims Author in New eBook
11. U.S. High Schools Lax in Preventing Dating Abuse: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... One of Australia,s successful biotechnology ... a new biotechnology company, Noxopharm Limited [ABN 50 608 966 123] ... to list on the ASX. Noxopharm is a clinic-ready ... a Phase 1 clinical study later this year. ... the biggest problems facing cancer patients - the ability of cancers ...
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/26/2016)... OTTAWA, Ontario , June 27, 2016  VMS ... the Company,s Board will take whatever measures required to ... the Company,s stock which is currently listed on the ... S Wexler, Company Chairman and CEO, "We are seeing ... be difficult to understand, not only by the Company, ...
Breaking Medicine Technology: