Navigation Links
A further step towards preventing diabetes
Date:7/26/2012

Pancreatic beta cells produce insulin, responsible for controlling blood sugar levels and thus essential for our survival. Among the numerous factors that affect the workings of these cells, a protein called Cx36 was identified a few months ago by a research team at the UNIGE. The scientists there had demonstrated that in transgenic mice, suitably modified so as not to produce any Cx36, synchronization of the beta cells ceased and insulin production went out of control. This de-synchronization of insulin secretion is the first measurable sign in people suspected of developing type 2 diabetes. Armed with this knowledge, the research team have set about finding molecules which act directly on Cx36 with the objective of developing a novel therapeutic approach to fighting diabetes.

Paolo Meda, Professor of Cellular Physiology and Metabolism in the University of Geneva's Faculty of Medicine, has set his team a real challenge - study the protein Cx36, present in minute quantities and almost impossible to detect using traditional techniques, and which has a half-life of around three hours!

Over one thousand drugs tested

Sabine Bavamian and Helena Pontes, researchers in Professor Meda's laboratory, set to work on developing a non-invasive system for understanding how Cx36 works. This project has been partly financed by the Juvenile Diabetes Research Foundation (USA) and the Swiss National Science Foundation and is using equipment in the Bio-Imaging department of UNIGE's Faculty of Medicine. The two scientists have been able to develop a new model using living cells which produce insulin and Cx36 in culture in order to be able rapidly to test a large number of potentially interesting molecules. With this novel approach, they have been able to analyse some 1040 molecules, enabling them to identify those that stimulate insulin production and those that inhibit it. Such discoveries should enable the roll out of new pharmacological treatment strategies for type 2 diabetes.

And what if animal venoms are not poisons after all?

Although there is now a large number of drugs that are prescribed for diabetics the world over to help alleviate insulin secretion de-synchronization, the majority of them have unfortunate side effects. And thus Professor Meda has decided to use the innovative technique developed by his team to test the effect on Cx36 of very different molecules, produced from animal venom. Such molecules should not give rise to the same type of problem posed by the traditional drugs used currently. The screening, or selection, of the venom should enable carrying out the necessary validation tests, initially in vitro, and then in vivo. We have some 3 to 5 years work ahead of us, but we have very serious hopes of discovering molecules which act exclusively on Cx36, unlike all the currently identified molecules, with a view to limiting side-effects, explains Professor Meda. In the fight against diabetes, scientists are exploring numerous avenues, some of which are rather surprising.


'/>"/>
Contact: Paolo Meda
paolo.meda@unige.ch
0041-793-532-215
Universit de Genve
Source:Eurekalert

Related medicine news :

1. LaStone Launches Merger with TIR Massage Stone To Further The Advancement of Massage Therapy Education in 2012
2. Hospitals for Poor May Struggle Further Under Health Care Reform
3. Environment key to preventing childhood disabilities
4. Preventing post-traumatic stress
5. A systems approach to preventing obesity in early life
6. Antiretroviral treatment for preventing HIV infection: an evidence review for physicians
7. Safe, simple eye test may help save lives by preventing stroke
8. Echocardiogram screenings are effective in preventing rheumatic heart disease
9. Preventing or better managing diabetes may prevent cognitive decline, according to UCSF study
10. Preventing Oral Diseases Begins in Pregnancy Claims Author in New eBook
11. U.S. High Schools Lax in Preventing Dating Abuse: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... NY (PRWEB) , ... May 23, 2017 , ... ... in the pharmaceutical and medical device sectors, today announced the winners of its ... • Entrepreneurs) represent the most influential people in the healthcare industry today. , ...
(Date:5/23/2017)... ... May 23, 2017 , ... London, May 23, 2017: Walter Schindler, ... this month as a Guest Speaker and Contributor to a weeklong series of classes, ... Purpose. , Walter Schindler and SAIL Capital have received ...
(Date:5/23/2017)... ... 2017 , ... Diagnotes, an Indianapolis-based digital healthcare communication company, ... secure clinical communication platform. The platform allows clinicians to easily escalate their preferred ... urgency of a situation. , “We know from our daily lives that ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... Therachat ... its new survey in an infographic on the current state of anxiety in support ... familiar with anxiety, was conducted in April 2017 and benchmarked general anxiety levels as ...
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... Today, Our ... Washington, MO with a public ribbon cutting ceremony. Since opening over a ... an alternative to the emergency room. The new Our Urgent Care walk-in clinic ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... 2017  Amy Baxter MD, chief executive officer and ... pain relief, was awarded a 2017 Top 40 Healthcare ... recognized at the MM&M Top 40 Healthcare Transformers dinner ... on May 10, 2017. The dinner followed a ... "beyond the pill."  "Innovation goes beyond invention," ...
(Date:5/10/2017)... , May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of ... is based on extensive data analysis from GHI,s hospitals ... hospitals database for the region. The GHI database covers 86% ... offering more than 130 data points for each institution in ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its ... board of directors for the Pharmaceutical Research and ... for membership. Biopharmaceutical companies will now have to ... order to be eligible to join PhRMA. ... the board is sending a clear message that ...
Breaking Medicine Technology: