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A fresh look at existing therapies: Researchers explore ways to teach approved drugs new tricks
Date:10/24/2007

ly expressed in Tarceva-sensitive tumors compared to resistant tumors, and the EGFR pathway signature predicted anti-EGFR treatment response in this second group of tumors.

We are excited because this reinforces the notion that targeted agents work in cases where the target is relevant, Dr. Jimeno said. We only need to take into consideration the enormous intricacy of cancer and use tools that permit us to factor in that complexity.

Dr. Jimeno adds this finding offers some good news in this difficult-to-treat cancer. GSEA or another tool like it might help us down the road to tailor anti-EGFR therapy to those patients most sensitive to it, and it also provides an alternative, more integrative way to think about how to look for pathways that are relevant in cancer, he said.


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Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

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