Navigation Links
A form of immune therapy might be effective for multiple myeloma
Date:5/12/2014

COLUMBUS, Ohio A new study by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) provides evidence that genetically modifying immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014 The researchers modified a type of human immune cell called T lymphocytes, or T cells to target a molecule called CS1, which is found on more than 95 percent of myeloma cells, and to kill the cells. The researchers grew the modified cells in the lab to increase their numbers and then injected them into an animal model where they again killed human myeloma cells. The findings were published in the journal Clinical Cancer Research.

"Despite current drugs and use of bone marrow transplantation, multiple myeloma is still incurable, and almost all patients eventually relapse," says co-principal investigator and multiple myeloma specialist Craig Hofmeister, MD, MPH, assistant professor of medicine and a member of the OSUCCC James Translational Therapeutics Program.

"This study presents a novel strategy for treating multiple myeloma, and we hope to bring it to patients as part of a phase I clinical trial as soon as possible," Hofmeister says.

"In particular, our study shows that we can modify T lymphocytes to target CS1, and that these cells efficiently destroy human multiple myeloma cells," says principal investigator Jianhua Yu, PhD, assistant professor of medicine and a member of the OSUCCC James Leukemia Research Program.

"An important possible advantage to this approach is that these therapeutic T cells have the potential to replicate in the body, and therefore they might suppress tumor growth and prevent relapse for a prolonged period," Yu says.

For this study, Yu, Hofmeister and their colleagues used cell lines and fresh myeloma cells from patients to produce genetically engineered T cells with a receptor that targets CS1. The researchers then tested the capacity of the modified cells to kill human multiple myeloma cells in laboratory studies and an animal model.

The study's key technical findings include:

  • Compared to control T cells, the modified T cells better recognized multiple myeloma cells that overexpressed CS1, and they became more activated following the recognition;

  • The researchers successfully modified fresh T cells from patients and showed that the cells can be grown (expanded) in the lab, and that they efficiently recognized and eradicated myeloma cells;

  • In animal models, the modified T cells greatly reduced the tumor burden and prolonged overall survival: All mice that received the modified T cells were alive 44 days after treatment versus 29 percent and 17 percent of the study's two control groups.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center
Source:Eurekalert

Related medicine news :

1. Immune cells found to fuel colon cancer stem cells
2. Autoimmune diseases may succumb to new drug strategy
3. Penn researchers find link between sleep and immune function in fruit flies
4. Study sheds light on how the immune system protects children from malaria
5. Is Parkinsons an autoimmune disease?
6. Halting immune response could save brain cells after stroke
7. MD Anderson, MedImmune join forces to advance cancer immunotherapy
8. Cancer vaccine could use immune system to fight tumors
9. Vitamin A may help boost immune system to fight tuberculosis
10. Immune cells need a second opinion
11. Benaroya Research Institute receives 7-year award to lead Immune Tolerance Network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... , ... September 20, 2017 , ... “Monique”: is ... uncomfortable situations. “Monique” is the creation of published author, Colleen Crispi, has owned four ... then Crispi has been involved in real estate and cooking. , “The doctor’s ...
(Date:9/19/2017)... New York, NY (PRWEB) , ... September 19, ... ... communications firm, announced today the addition of strategic marketing leader, Denise Flannery, to ... as Strategic Marketing, Brand and Management Consultant, Denise will work with clients across ...
(Date:9/19/2017)... ... September 19, 2017 , ... Peter Chandonait, ... President’s Malaria Initiative (PMI) Africa Indoor Residual Spraying (AIRS) Project , has ... , The Innovation to Action Award, a USAID Catalyst Award, recognizes USAID staff ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... winners of the Entrepreneur Innovation Awards (EIA), held this past Thursday night at ... Connecticut-based companies and entrepreneurs, presented their innovative project ideas to a panel of ...
(Date:9/19/2017)... ... September 19, 2017 , ... The American Board ... to watch for the discomforts and hidden dangers of foot fungus, particularly in ... is at risk for developing fungal infections on the feet or toenails, the ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... Sept. 6, 2017  Medical professionals are ... skills while treating their patients. Medical simulations ... without involving patients. Simulation provides a safe ... carry out procedures, refine techniques and build ... of new technology, such as augmented reality, ...
(Date:9/6/2017)... NeuroRx, a clinical stage biopharma company developing the ... has been granted Fast Track status by the US Food ... HCl) followed by NRX-101 (D-cycloserine + lurasidone). The company will ... sequential therapy targeting patients who are admitted to Emergency Departments ... ...
(Date:9/5/2017)... -- Sapheneia and Scannerside received FDA 510(k) clearance to ... third-party Vendor neutral CT product that makes it affordable ... current MITA standards. ... specifically designed to provide CT operators, prior to a ... a predefined threshold. Scannerside Dose Check is intended to ...
Breaking Medicine Technology: