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A fish a day keeps the doctor away?
Date:5/3/2012

rough marine phytoplankton and pass through fish.

The initial trials showing a benefit for omega-3 in the secondary prevention of patients with established CVD were:

  • The Diet and Reinfarction Trial (DART), 1989, in 2,033 men who had suffered an MI showed a 29% reduction in all-cause mortality among those who received advice to add two fatty fish meals per week (300 g of oily fish) or to take fish oil capsules providing an equivalent intake of marine omega-3 (3).
  • The Gruppo Italiano per lo Studio della Sopravvienza nell'Infarto (GISSI) Prevenzione trial, 1999, which enrolled 11,324 patients within three months of an MI, showed that marine omega-3 fatty acids (885 mg EPA+DHA per day) lowered the risk of the combined primary outcome of death and non-fatal cardiovascular events by 15% (4).
  • The JELIS study, 2007, which involved 18,645 Japanese patients with hypercholesterolaemia, with or without pre-existing coronary artery disease, showed that long-term use of 1.8 g of purified EPA daily lowered the risk of the combined primary outcome of death and non-fatal cardiovascular events by 15% (5).

However, in 2010, three large trials - Alpha Omega, OMEGA, and SU.FOLOM3 all failed to confirm the benefits of omega-3 fatty acids supplements on CVD events.

Each of these later studies, said Berg Schmidt, had issues related to the marine omega-3 fatty doses used, the exact mix of EPA and DHA, the lag between when the MI occurred and initiating omega-3 fatty acid treatment, the use of newer invasive and non-invasive strategies, the length of follow-up and sample size, which in some cases was too small to show a beneficial effect.

Fish intake in primary prevention

Following the first epidemiological observations in Greenland Inuits, Kromhout told delegates, prospective cohort studies carried out in European, American, Japanese, and Chinese populations also showed inverse associations between fish c
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Contact: ESC Press Office
press@escardio.org
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European Society of Cardiology
Source:Eurekalert

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