Navigation Links
A few circulating cancer cells could cue risk of metastases
Date:6/9/2014

St. Louis, Mo. (June 9, 2014) A simple noninvasive blood test matched with state-of-the-art molecular imaging of individual cells could help oncologists understand their patients' chances of survival, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.

Metastasis accounts for an estimated 90 percent of cancer deaths. For decades, researchers tried to develop a way to gauge a cancer's risk of metastasizing from a blood samplethe long-sought-after liquid biopsy. Today there are numerous methods available to isolate lone cells. Novel methods recently used to study those cells are radioluminescence microscopy, which combines nuclear medicine, optical imaging and single-cell autoradiography (SCAR), used to localize the micro-distribution of radioactive substances in a single cell in order to image a particular physiological process, such as a receptor expressing genetic information or an enzyme involved in cellular metabolism.

"We are now starting to study the properties of these lone cancer cells, which could be predictive of different disease states and that understanding could help guide therapy decisions," said Laura S. Sasportas, a principal researcher and PhD candidate in the Gambhir Lab in the department of bioengineering at Stanford University in Stanford, Calif. "The great potential of looking at circulating tumor cells (CTCs) has been limited mainly by their extreme rarity. For example, in the case of breast cancer, CTCs are estimated to be in the order of a few to a few hundred cells among billions of blood cells in a typical 7.5 milliliter blood sample from a cancer patient. In the past decade, however, CTC research has been booming due to the development of exciting new technologies that can sensitively detect and harvest those very rare cells from patient's blood."

For this study, researchers took breast cancer cells isolated from the blood of small animal models and imaged them using radioluminescence microscopy and SCAR along with a common molecular imaging radiotracer called F-18 fluorodeoxyglucose (FDG). The latter mirrors the exchange of energy in the presence of glucose in order to target the few hyper-metabolic cancer cells within these blood samples. Results of the research showed that less than three percent of CTCs in the sample indicated increased cellular metabolism compared to the parent cancer cell line. Researchers are not yet sure if this indicates an aggressive cancer cell or not. Further research and validation in clinical trials is needed to strengthen the theory.

"We hypothesize that the unexplored metabolic characterization of CTCs could provide valuable information for disease monitoring," said Sasportas. "By evaluating the glucose metabolism of CTCs with F-18 FDG, we could better manage the care of cancer patients by improving therapy selection and therefore avoiding unnecessary treatment."

Cancer remains a top cause of death across the globe. It was thought to account for approximately 8.2 million deaths in 2012, according to current World Health Organizations statistics. Lung, liver, stomach, colorectal and breast cancer are associated with the highest mortality.


'/>"/>

Contact: Kimberly Brown
kbrown@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. New technology using florescent proteins tracks cancer cells circulating in the blood
2. NCCS and Clearbridge Biomedics open the regions first circulating tumor cell center
3. Circulating tumor cells in blood can predict a patients response to chemotherapy
4. New research finds flu shot effective regardless of circulating flu strain
5. Sous Vide Circulating Bath Systems Enable Chefs to Achieve Perfect Results
6. Detecting circulating tumor cells
7. New technology allows scientists to capture and preserve cancer cells circulating in the bloodstream
8. Capturing circulating cancer cells could provide insights into how disease spreads
9. Molecular imaging finds novel way to knock down breast cancer
10. PSMA-based imaging traces even treatment-resistant prostate cancer
11. Molecular breast imaging protocol unmasks more cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Surgical Procedure Volumes: Global Analysis (United States, ... Australia, Canada)" report to their offering. ... an essential tool for healthcare business planners, provides surgical ... looks at surgery trends with an in-depth analysis of ...
(Date:6/23/2016)... , June 23, 2016 The ... it continues to present great opportunities to investors. Stock-Callers.com ... today: Intrexon Corp. (NYSE: XON ), Vertex ... Inc. (NASDAQ: ARNA ), and Regeneron Pharmaceuticals ... these stocks and receive your complimentary trade alerts at: ...
(Date:6/23/2016)... , June 23, 2016 Leading BioSciences ... address medical conditions resulting from a breakdown of ... appointed Greg Doyle as chief executive ... BioSciences, executive management team and board of directors, ... financial officer. He will provide continued leadership and ...
Breaking Medicine Technology: