Navigation Links
A feasible, simple and convenient model for study of rectal carcinoma
Date:5/13/2009

The method of building a rabbit rectal VX2 carcinoma model by injecting the cell suspension of VX2 cells into the wall of the rectum guided by X-ray fluoroscopy is feasible. The advantages of the model are ease of establishment, short growth period, and high stability. The rectal VX2 carcinoma established in this rabbit model is similar to human rectal carcinoma in aspects of pathological representation, tumor development, and metastasis. It offers an ideal major animal model for the study of rectal carcinoma, and especially profits the study of the staging of rectal carcinoma in imaging.

A research article to be published on May 7, 2009 in the World Journal of Gastroenterology addresses this question. The research, led by Dr. Cheng from Department of Radiology, the Tenth People's Hospital of Shanghai Tong Ji University, is to establish a rabbit model of rectal VX2 carcinoma for a feasible, simple, and convenient method for the study of rectal carcinoma. Currently, the experimental animal models for the research of rectal carcinoma are often established using induction of chemical carcinogen, and little murid is most often used. This kind of methods requires lots of time and individual variations can be very large. Overall it is difficult to obtain consistent, single tumor which are representative of the course of rectal disease in humans, and it is adverse to perform the research of rectal carcinoma.

The method of building a rabbit rectal VX2 carcinoma model by injecting the suspension of VX2 cells into the wall of the rectum guided by X-ray fluoroscopy is feasible. The advantages of the rectal VX2 carcinoma established in this rabbit model are ease of establishment, short growth period, and high stability.

The model is repeatable and can be monitored dynamically using imaging provided by CT and MRI. It profits the research of rectal carcinoma, especially in the aspect of rectal carcinoma's staging in imaging.

Many studies have described the implantation of the VX2 cell strain into the muscle, kidney, lung, pleural, ossature, and mammary gland of rabbit in order to produce an in situ tumor model that mimics the human condition for research of possible treatments. The implantation technique using VX2 cells which included implanting a little lump of VX2 tumor tissue or injection of the suspension of VX2 cells directly by surgery, and injection of the suspension of VX2 cells guided by B-mode ultrasonics or CT is reliable.

Both the Sixth People's Hospital of Shanghai Jiao Tong University and the Tenth People's Hospital of Shanghai Tong Ji University are general hospital and teaching hospital. The Department of Radiology of the Sixth People's Hospital of Shanghai Jiao Tong University has set one study organization(Institute of Imaging Medical of Shanghai Jiao Tong University), two clinic parts(department of image and the center of neurointerventional), and five second branches(head and neck, musculoskeletal, chest, abdomen and interventional).


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Simple Steps Toward a Healthy Lifestyle
2. Simple blood test proves powerful ally in the fight against malaria
3. Simple Steps to Maintaining Memory
4. Simplex Diabetic Supply Changes Its Name to Simplex Healthcare
5. Nick Jonas and Bayer Diabetes Care Launch Creativity Contest to Encourage Kids With Diabetes to Express Their Simple Win
6. New, simple method identifies preterm infants at risk of eye disease
7. Mayo study shows simple finger device may help predict future heart events, such as heart attack
8. Mayo Study Shows Simple Finger Device May Help Predict Future Heart Events, Such as Heart Attack
9. Getting Social Security Disability Benefits Isn't Simple, Even After Approval
10. A simple balance test may predict cognitive decline in Alzheimers disease
11. Simple Test Helps Predict Heart Attack Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... SYDNEY , June 26, 2016 One of ... , has announced the formation of a new biotechnology company, Noxopharm ... raise $6m in an IPO and to list on the ASX. ... drug candidate, NOX66, ready to enter a Phase 1 clinical study ... been designed to address one of the biggest problems facing cancer ...
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, ... Board will take whatever measures required to build a ... stock which is currently listed on the OTC Markets-pink ... Company Chairman and CEO, "We are seeing an anomaly ... to understand, not only by the Company, but shareholders ...
Breaking Medicine Technology: