Navigation Links
A fat cell grows up
Date:5/17/2010

PHILADELPHIA Getting from point A to B may sound simple, but not so in the formation of fat cells.

In a finding with potential drug-development implications, Mitchell A. Lazar, M.D., Ph.D., director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania School of Medicine, and colleagues report in the current issue of Genes & Development the discovery of an intermediate state between early-stage fat cells and fully mature ones that is only present transiently during the fat-cell formation process. This intermediate state is induced by hormones related to cortisol, which are known to contribute to obesity and metabolic disturbances in people.

New therapies for obesity or metabolic diseases such as diabetes could potentially target this transition state toward a maturing fat cell.

The transition state present within 24 hours of the start of the fat-cell differentiation process is defined by chemical changes to genetic material called chromatin, which package a cell's DNA. These changes kick start the expression of regulatory proteins and provide a cellular memory that allows the cell to continue developing even after the signal to undergo this transition has waned.

Probing the Genome

Like all cells in the body, fat cells arise from stem cells. Embryonic stem cells give rise to another type of stem cell, which in turn gives rise to early-stage fat cells. Upon stimulation, those early cells complete their differentiation to become fully mature fat cells. Lazar and his team asked: What are the molecular players required to induce the final transformation?

Using a cell culture system, the team, led by postdoctoral researcher David Steger, PhD, probed genes involved in fat-cell development and function for chromatin changes that were associated with the start of mature fat-cell formation. They found chromatin changes near a gene encoding the master regulator of d
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Texas Childrens Cancer Center first in Texas to magnetically lengthen 9-year-olds leg as she grows
2. NJHA: Charity Care Must Be a Priority as Uninsured Burden Grows
3. As girth grows, risk of sudden cardiac death shrinks
4. SciAnswers.com Grows and Adds a Technical and Healthcare Professionals Job Board.
5. Service Foods Reduces its Carbon Footprint and Grows Sales
6. Pet Health Insurance Grows as Pets Live Longer and Healthier Lives
7. Transplanted Trachea Grows Own Blood Supply in Patients Arm
8. Urinary Incontinence Rates Increase Worldwide As Awareness Grows About Treatment Options: Urethral Slings Are Popular Alternatives When Medications Fail
9. The Flag Company, Inc.'s Recently Released “Feel Good” Light Lenses Grows Into Its Own Website
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A fat cell grows up
(Date:7/23/2014)... July 24, 2014) If past experience is anything ... are about to get a lot more recognition for ... on the books allowing NPs to provide primary care ... care and better relationships with physicians and administrators, compared ... from Columbia University School of Nursing, published in ...
(Date:7/23/2014)... 2014 Celebrating a decade of philanthropy ... announced the awarding of $1,070,000 in grants to 20 ... recognition of the Foundation’s 1,000th grant. , “The Horizon ... tradition of supporting community-based organizations that are working to ... in the Garden State,” said Robert A. Marino, Horizon ...
(Date:7/23/2014)... body of research suggesting a safe and effective ... breast cancer, with fewer detrimental side effects and ... The study will be published in final format ... and Endocrinology . , Breast cancer is the ... United States. Approximately 70% of breast cancers are ...
(Date:7/23/2014)... 23, 2014 Global Cardio Care, Inc., ... External Counterpulsation (EECP), is celebrating the 100th birthday ... at the health center. , Weber has been ... receiving ongoing EECP therapy since 1999, he no longer ... CEO of Global Cardio Care, introduced the Sara ...
(Date:7/23/2014)... The voice on the recording was low and calm as ... was infected with the human immunodeficiency virus (HIV) that causes AIDS: ... you know I was on the floor flat on my face ... when the recording ended less than 10 minutes later. “Don’t feel ... because it is just God setting you up for something greater,” ...
Breaking Medicine News(10 mins):Health News:New York law offers nurses more recognition, responsibility 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 3Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 4Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 5Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:Global Cardio Care Celebrates EECP Patient’s 100th Birthday 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 3
... cancer center at NYU Langone Medical Center, identified for ... (miRNAs) play in melanoma metastasis to simultaneously cause cancer ... to fight abnormal cells. The new study is published ... Cancer Cell. Researchers performed a miRNA ...
... , MONDAY, July 11 (HealthDay News) -- Too much salt ... risk for cardiovascular disease and death, a new study shows. ... pressure and high levels of salt consumption and low levels ... called sodium -- and low potassium appears to convey a ...
... Dotinga HealthDay Reporter , MONDAY, July 11 ... in their homes face a higher risk of developing ... new study finds. The research doesn,t definitively ... it doesn,t say how much smoke is too much. ...
... By Denise Mann HealthDay Reporter , MONDAY, ... reduce the risk of lasting neurological damage, but this lifesaving ... local hospitals don,t have the proper systems in place, and ... arrest to be effective, according to the report in the ...
... DETROIT Na Zhu, a Wayne State University College ... Association Student Research Grant Program award. The program financially ... a cure for tinnitus. Zhu, a Ph.D. ... Professor in the Department of Mechanical Engineering, is developing ...
... that can accumulate to high levels in our body ... linked to an increased risk of cancer and/or impaired ... by Sridhar Mani, at Albert Einstein College of Medicine, ... between environmental exposure to these foreign chemicals (xenogens) and ...
Cached Medicine News:Health News:Researchers identify key role of microRNAs in melanoma metastasis 2Health News:Study: Potassium Boosts Heart Health, Salt Harms It 2Health News:Study: Potassium Boosts Heart Health, Salt Harms It 3Health News:ADHD, Learning Issues May Be Linked to Secondhand Smoke 2Health News:Coordinated Cooling Effort After Cardiac Arrest Can Improve Outcomes 2Health News:Coordinated Cooling Effort After Cardiac Arrest Can Improve Outcomes 3
(Date:7/23/2014)...  The management team at Columbia Laboratories, Inc. ... conference call on July 31, 2014, to discuss ... 30, 2014.  The call details are as follows:Date: ... EDTDial-in numbers: , Toll free: (877) 870-4263 (U.S.), ... archive): , www.columbialabs.com , under ,Investor, or ...
(Date:7/23/2014)... ORANGE, Calif. , July 23, 2014 ... will gather in Las Vegas ... event. Spearheaded by educator, author, forward thinker and private ... to bring experts together to candidly discuss clinical and ... two day event is a unique opportunity to welcome ...
(Date:7/23/2014)... , July 23, 2014  Silk Road ... the transcarotid treatment of intra- and extra-cranial cerebrovascular ... P. Wallace to the position of Chief ... lead the company,s Research and Development efforts across ... Prior to joining Silk Road ...
Breaking Medicine Technology:Columbia Laboratories to Discuss Second Quarter 2014 Financial Results on July 31st Conference Call 22014 DOCtalk Registration Now Open 22014 DOCtalk Registration Now Open 3Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 2Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 3
... Analyzes the Effectiveness and Safety of Statin Use for Those Who Need It , ... Recommendations for Choosing a ,Best Buy, Statin and Strategies for ... YONKERS, N.Y. , June 29 ... ) caution that the benefits of statin use by children and some women may ...
... Initiative Launched on Biosafety , , ... WASHINGTON , June 29 Remember chemistry sets, ham radio, amateur ... 2,000 people from around the world belong to the Do-It-Yourself Biology (DIYbio) community, ... bio-monitoring, to new treatments for diseases. , ...
Cached Medicine Technology:Consumer Reports Health Questions Use of Statins By Children and Some Women 2Consumer Reports Health Questions Use of Statins By Children and Some Women 3Consumer Reports Health Questions Use of Statins By Children and Some Women 4Consumer Reports Health Questions Use of Statins By Children and Some Women 5Consumer Reports Health Questions Use of Statins By Children and Some Women 6Consumer Reports Health Questions Use of Statins By Children and Some Women 7Responsible Science for Do-It-Yourself Biologists 2
... The Self-Cath family of ... patients a variety of ... Each catheter is ... grade PVC and has ...
... The Self-Cath family of ... patients a variety of ... Each catheter is ... grade PVC and has ...
IMMCO ANA Elisa meets the guidelines for the laboratory diagnosis and monitoring of systemic autoimmune rheumatic diseases intended for the use of clinical pathologists and laboratory physicians....
... is engineered to distribute contact pressure evenly over ... back, to maximize stability and patient comfort. ... readily conformable to patient anatomy, to provide a ... wool liner is standard on both units, as ...
Medicine Products: