Navigation Links
A drug-sensitive 'traffic cop' tells potassium channels to get lost
Date:9/2/2007

La Jolla, CA Our brains are buzzing with electrical activity created by sodium and potassium ions moving in and out of neurons through specialized pores. To prevent the constant chatter from descending into chaos the activity of these ion channels has to be tightly regulated.

One possibility is to issue the channels a ticket straight to the cellular dumpster, discovered researchers at the Salk Institute for Biological Studies. A novel intracellular traffic coordinator pulls potassium channels from their job and whisks them to the recycling plant when not needed to put a damper on brain cells excitability, they report in the September issue of Nature Neuroscience.

Neurons have the task of integrating many incoming signals from other neurons and must strictly regulate their intrinsic membrane excitability, says Paul A. Slesinger, Ph.D., an associate professor in the Peptide Biology Laboratory at the Salk Institute who led the study. Controlling the surface expression of ion channels with the help of trafficking molecules is a very efficient way to do it, he adds.

Brain cells signal by sending electrical impulses along their axons, long, hair-like extensions that reach out to neighboring nerve cells. They make contact via specialized structures called synapses, from the Greek word meaning to clasp together. When an electrical signal reaches the end of an axon, the voltage change triggers the release of neurotransmitters, the brains chemical messengers.

These neurotransmitter molecules then travel across the space between neurons and set off an electrical signal in the adjacent cell unless the receiving end is decorated with so called GIRK channels, that is. In response to incoming signals, these channels open up, creating many little potassium leaks and as a result the signal fizzles.

GIRK channels (short for G-protein-coupled inwardly rectifying potassium channels) a subtype of the many different potassium channel
'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Traffic Violations Result in Safer Drivers
2. Drug trafficking via Internet a growing threat
3. Traffic pollution linked to severe asthma attacks
4. Traffic Smoke May Damage DNA
5. HIV Infection Higher In Drug Trafficking Countries
6. Alcohol And Drug Abuse (Cannabis) Leading Causes For Road Traffic Accidents
7. Trafficking of Women from Asia and East Europe For Flesh Trade
8. Travel And Tourism Industry Calls For Global Efforts To Limit Sexual Trafficking Of Children
9. Asthma Risk Pronounced In Children Living Close to Traffic Ridden Roads
10. Striking Doctors Form Human Chain, Block Traffic
11. Road Traffic Accidents Kill 4,000 people in Delhi
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... Chicago, October 30, 2014—Analysis of data from an ... indicates excellent long-term, local control, 79 percent of ... patients treated with SBRT from 2003 to 2012, ... Chicago Multidisciplinary Symposium in Thoracic Oncology. The Symposium ... Oncology (ASCO), the American Society for Radiation Oncology ...
(Date:10/30/2014)... Beach, Florida (PRWEB) October 30, 2014 ... Halloween visit to Pompano Beach firefighters, showing that you ... community. , Timothy met firefighters Tracey and Carl ... by Galuppi’s Restaurant and the Pompano Beach Chamber of ... outside the fire truck, letting Timothy wear his real ...
(Date:10/30/2014)... PreDiabetes Centers , the pioneer ... shoppers with a supply of sugardown®, a chewable dietary ... blood sugar spikes. Learning how to control blood sugar ... of a diabetes prevention plan. , Shoppers who spend ... tube of sugardown. The offer expires November 30. ...
(Date:10/30/2014)... Dennis Thompson HealthDay ... The Ebola outbreak in Liberia -- one of three West ... World Health Organization officials said Wednesday. Dr. Bruce Aylward, ... the number of burials in Liberia and no increase in ... global push to tame the epidemic may be making some ...
(Date:10/30/2014)... Fort Lauderdale, FL (PRWEB) October 30, 2014 ... leading US Joint Commission Accredited teleradiology and specialty ... today that in addition to its existing teleradiology ... adding multispecialty second opinion and expert telemedicine services, ... Houston, Texas. , As a result of this ...
Breaking Medicine News(10 mins):Health News:Sustained local control for medically inoperable, early stage lung cancer patients 2Health News:Sustained local control for medically inoperable, early stage lung cancer patients 3Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 2Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 3Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 4Health News:PreDiabetes Treatment Company Offers PreD Store Shoppers Supplements to Support Healthy Blood Sugar 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 2Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 3
... it was found that triple drug therapy helped people suffer ... a clot-preventing drug such as aspirin, an ACE inhibitor for ... that these drugs work synergistically to reduce the amount of ... a neurologist at Harvard Medical School and co-director of the ...
... that women who drink insufficient milk during pregnancy probably to ... inhibit// their babies’ growth in the womb. ,The ... Association Journal. 300 women took part in the study. All ... babies of mothers who drank at least a cup of ...
... to lead can induce hypertension in lab animals and more ... adults too. But till now nothing concrete was known about ... to expose to lead for five years researchers have found ... ,Lead's most widely documented effects are neurological. Exposure ...
... will become the benchmark against which the growth of babies ... from the practice of almost 4 decades, //where babies have ... growth pattern portrayed by formula- fed babies. ,It ... rate as compared to breast fed infants and this makes ...
... the American Civil Liberties Union are questioning the policy ... and customs agents to detain travelers //who look like ... is reportedly available with Reuters, also allows Customs and ... ,Health and Human Services Secretary ...
... the advertisement on junk foods shown on television poses ... by tempting them to go for it thereby leading ... foodconsumer.org, previous studies have already associated childhood overweight with ... link between childhood overweight and TV viewing is due ...
Cached Medicine News:Health News:Limiting milk can hamper Babies’ Growt 2Health News:Exposure To Lead Doesn’t Cause Hypertension In Childre 2Health News:Junk Food Ads: The Culprit Behind Childhood Obesity 2
(Date:10/30/2014)... 2014 Stryker Orthopaedics, the Official Joint Replacement ... rounding out its debut year of the relationship at ... AZ. This marks the eleventh tournament stop ... the brand has activated on-site with the "Stryker Mobility ... on the importance of joint health.  ...
(Date:10/30/2014)... 30, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... technology platform company serving the pharmaceutical, biotechnology, and medical ... and the United States , ... the Tel Aviv area of ... WuXi,s broad platform of integrated R&D services to local ...
(Date:10/30/2014)... Mass. , Oct. 30, 2014 Boston ... to participate in the 2014 Credit Suisse Annual Healthcare ... Phoenix , AZ.  Dan Brennan , executive ... presentation about the company beginning at approximately 8:00 a.m. ... A live webcast of the presentation and question ...
Breaking Medicine Technology:Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 3Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 4WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2
... day surgery and post anesthesia care in one ... is a high performance monitor designed for the ... and induction rooms. It offers the flexibility of ... advanced airway gas monitoring. When paired with the ...
... The complete picture of patient respiration and ... the most versatile respiration and ventilation monitors available. ... models. Each model allows you to measure the ... O 2 , and N 2 O easily ...
For accurately monitoring heart and breath sounds....
For accurately monitoring core temperature and heart and breath sounds....
Medicine Products: