A drug-sensitive 'traffic cop' tells potassium channels t...( La Jolla CA Our brains are buzzing ...),Health

La Jolla, CA Our brains are buzzing with electrical activity created by sodium and potassium ions moving in and out of neurons through specialized pores. To prevent the constant chatter from descending into chaos the activity of these ion channels has to be tightly regulated.

One possibility is to issue the channels a ticket straight to the cellular dumpster, discovered researchers at the Salk Institute for Biological Studies. A novel intracellular traffic coordinator pulls potassium channels from their job and whisks them to the recycling plant when not needed to put a damper on brain cells excitability, they report in the September issue of Nature Neuroscience.

Neurons have the task of integrating many incoming signals from other neurons and must strictly regulate their intrinsic membrane excitability, says Paul A. Slesinger, Ph.D., an associate professor in the Peptide Biology Laboratory at the Salk Institute who led the study. Controlling the surface expression of ion channels with the help of trafficking molecules is a very efficient way to do it, he adds.

Brain cells signal by sending electrical impulses along their axons, long, hair-like extensions that reach out to neighboring nerve cells. They make contact via specialized structures called synapses, from the Greek word meaning to clasp together. When an electrical signal reaches the end of an axon, the voltage change triggers the release of neurotransmitters, the brains chemical messengers.

These neurotransmitter molecules then travel across the space between neurons and set off an electrical signal in the adjacent cell unless the receiving end is decorated with so called GIRK channels, that is. In response to incoming signals, these channels open up, creating many little potassium leaks and as a result the signal fizzles.

GIRK channels (short for G-protein-coupled inwardly rectifying potassium channels) a subtype of the many different potassium channel
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