Navigation Links
A double block of blood vessels to starve cancerous tumors
Date:12/9/2010

A novel strategy of blocking the growth of blood vessels with antibodies should result in improved treatment of cancerous tumors.

The growth of new blood vessels from pre-existing vasculature is called angiogenesis. In adults, angiogenesis occurs only during wound healing and menstrual cycling, but is abundant and harmful in cancerous tumors and the old-age eye disease frequently leading to blindness called age-related macular degeneration (AMD). Without the formation of new blood vessels, tumors cannot grow beyond a small size due to lack of oxygen and nutrients. Inhibition of angiogenesis is used in the treatment of cancer and AMD, but not all cancer patients respond, while others become refractory to therapy.

Academy professor Kari Alitalo and co-workers at the University of Helsinki, Finland, have previously shown that antibodies directed towards vascular endothelial growth factor receptor (VEGFR)-3, found on the surface of endothelial cells lining vessels, can inhibit lymphatic metastasis by 50-70% in preclinical tumor models. Furthermore, antibodies that inhibited the growth factor VEGF-C from binding to the VEGFR-3 suppressed angiogenesis. However, the trouble with this type of inhibitors is that they work poorly in high growth factor concentrations, when the growth factor easily outcompetes the inhibitor. Also the delivery of drugs into tumors is hampered by erratic blood flow and high tumor pressure, which may prevent sufficient amounts of the inhibitor from reaching its target within the tumor.

The novel type of VEGFR-3 blocking antibody has an unprecedented mechanism of action, which was effective even at very high concentrations of the VEGF-C growth factor. Importantly, the authors showed that combined use of antibodies blocking growth factor binding VEGFR-3 dimerization provided not only an additive, but rather a synergistic inhibition.

"The new dimerization inhibitor unveils a biologically meaningful ration
'/>"/>

Contact: Kari Alitalo
kari.alitalo@helsinki.fi
358-505-003-572
University of Helsinki
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Major depression more than doubles risk of dementia among adults with diabetes
2. Obesity, Drinking a Double Threat to the Liver
3. De-Duplication, Compression and No Double Backups Required: AppAssure Releases the Fastest and Most Scalable Backup & Recovery Solution for Microsoft Hyper-V
4. Henry Ford Hospital atudy: Hepatitis C infection doubles risk for kidney cancer
5. Obesity and weight gain near time of prostate cancer surgery doubles risk of recurrence
6. Look Out KFC Double Down, IHOP Pancake Stacker & BK Mimosa - Freshii Launches Zero Calorie Menu with Elemental Sides
7. Radiation Risks Nearly Double for Younger CT Scan Patients
8. Medical costs of cancer have nearly doubled over the past 2 decades
9. U.S. Cancer Costs Double in Two Decades
10. Female-to-Male HIV Transmission Risk Doubles During Pregnancy
11. Pregnancy doubles HIV risk in men; first trial of a microbicide in pregnant women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A double block of blood vessels to starve cancerous tumors
(Date:12/22/2014)... Give a loved one the greatest gift ... and vitality. , For a limited time, HealthiPlus ( ... in special Holiday Wellness gift packages at drastically reduced ... bottle contains cutting-edge, proven nutritional support for joints, mental ... as we age. , Joint Health Plus ...
(Date:12/22/2014)... December 22, 2014 Pasadena sleep ... consultations for sleep apnea. Drowsy drivers are 15 times ... who are well-rested, and some experts believe that sleep-deprived ... as intoxicated drivers. Unfortunately, millions of Americans may be ... Academy of Sleep Medicine, about 18 million Americans have ...
(Date:12/22/2014)... Branch, TX (PRWEB) December 22, 2014 ... revolutionary work glove with many useful features. Customers of ... and can have the new gloves delivered to their ... work gear and hand tools that incorporate heavy duty ... Utility Magnetic Glove allows workers to store metal parts ...
(Date:12/22/2014)... December 22, 2014 NAPW ... Professional Woman of the Year. Ms. Foley is recognized ... the largest, most-recognized networking organization of professional women in ... National Association of Professional Women is a powerfully vibrant ... Local Chapters. , “As a nurse, I felt like ...
(Date:12/22/2014)... 2014 The NLN’s 2015 ... programs this month. Faculty have been selected through ... educators fast-tracked for administrative leadership roles within their ... for Simulation Educators, featuring a curriculum uniquely devised ... education. , Twenty nurse educators were chosen ...
Breaking Medicine News(10 mins):Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:NLN Leadership Institute Announces 2015 Cohorts 2Health News:NLN Leadership Institute Announces 2015 Cohorts 3
... to researchers, new bandages developed by US researchers take ... mice show that hydrogel bandages speed up healing.They look ... times and become pliable when wet.// Unlike regular bandages, ... hydrogel dressings actually penetrate the wound and enhance the ...
... have observed that, people suffering from heat diseases are better ... but for a few it might prove too much.People who ... still safe to enjoy a game of golf.// Researchers at ... 15 male golfers, aged between 50 and 75, half of ...
... studied on African tribe, most of the things being equal ... to be healthier for the heart than eating a vegetarian ... the body control blood levels of leptin,// a substance secreted ... increased risk for heart attack and stroke. ,Lead author ...
... has found that caffeine is often used to treat ... is a condition characterized by cessation in breathing and ... growing concern over caffeine's effects on a baby's circulatory ... caffeine on cardiac output, specifically studying the effects on ...
... important tips regarding splitting a pill and ways of taking care ... a whole one. one might be neglecting off a medication, or ... way, you may need to split a pill into two or ... some advice on how to go about pill splitting. First, you ...
... offer some valuable advice on how to make sure your ... bones and teeth, and helps prevent osteoporosis and any bone ... produce vitamin D.// Just10 to 15 minutes of natural sunlight ... many factors can reduce sunlight exposure, such as windows, sunscreen, ...
Cached Medicine News:Health News:Fish rich diet lowers leptin 2Health News:Caffeine reduces infant blood flow 2
(Date:12/19/2014)... 19, 2014  Advanced Medical Isotope Corporation ("AMIC") ... primarily in the development of brachytherapy devices and ... announced that a Life Sciences Discovery Fund (LSDF) ... which AMIC is the commercialization partner.  The award ... the proposal titled "Optimized Injectable Radiogels for High-dose ...
(Date:12/19/2014)... Ill. , Dec. 19, 2014   Hospira, ... leading provider of injectable drugs and infusion technologies, today ... Morgan 33rd Annual Healthcare Conference on Wednesday, Jan. 14, ... presentation is scheduled to begin at 10:30 a.m. Pacific ... available to all interested parties through a live audiocast ...
(Date:12/19/2014)... HILL, N.C. , Dec. 19, 2014 /PRNewswire/ ... innovative consumer research and marketing communication tools are ... and globally competitive – consequently consumers, desires, preferences, ... In this environment, market research groups across all ... and marketing communication tools. However, the adoption of ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 2Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 3Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2
... 20, 2012 /PRNewswire-Asia/ -- China Health Resource, Inc. (OTCBB: CHRI), ... exclusive agreement with a leading producer of Gastrodia in Pingwu, ... to March 31, 2015, and extends the very successful product ... which will end March 31, 2012.  The quality of Gastrodia ...
... 20, 2012  INVO Bioscience, Inc. (OTC BB: IVOB), a ... diagnosed with infertility, today announced that the National Health ... the INVOcell for use as a Class II device. ... millions of infertile couples in Brazil and marks a ...
Cached Medicine Technology:China Health Resource Signs 3 Year Exclusive Agreement for Acquisition of Gastrodia Extending Very Successful Product Line Through 2015 2China Health Resource Signs 3 Year Exclusive Agreement for Acquisition of Gastrodia Extending Very Successful Product Line Through 2015 3INVO Bioscience Announces Approval of INVOcell by Brazil's ANVISA 2INVO Bioscience Announces Approval of INVOcell by Brazil's ANVISA 3
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
... Phoroptor features lighted dials to make it ... in the darkened setting of the exam ... leave the lights off throughout the entire ... cylinder power and cylinder axis scales that ...
... The Reichert CT200 Tonometer ... the XCEL 250 and XCEL ... also compatible with other Zeiss-style ... mounted on the top of ...
Medicine Products: