Navigation Links
A double block of blood vessels to starve cancerous tumors
Date:12/9/2010

A novel strategy of blocking the growth of blood vessels with antibodies should result in improved treatment of cancerous tumors.

The growth of new blood vessels from pre-existing vasculature is called angiogenesis. In adults, angiogenesis occurs only during wound healing and menstrual cycling, but is abundant and harmful in cancerous tumors and the old-age eye disease frequently leading to blindness called age-related macular degeneration (AMD). Without the formation of new blood vessels, tumors cannot grow beyond a small size due to lack of oxygen and nutrients. Inhibition of angiogenesis is used in the treatment of cancer and AMD, but not all cancer patients respond, while others become refractory to therapy.

Academy professor Kari Alitalo and co-workers at the University of Helsinki, Finland, have previously shown that antibodies directed towards vascular endothelial growth factor receptor (VEGFR)-3, found on the surface of endothelial cells lining vessels, can inhibit lymphatic metastasis by 50-70% in preclinical tumor models. Furthermore, antibodies that inhibited the growth factor VEGF-C from binding to the VEGFR-3 suppressed angiogenesis. However, the trouble with this type of inhibitors is that they work poorly in high growth factor concentrations, when the growth factor easily outcompetes the inhibitor. Also the delivery of drugs into tumors is hampered by erratic blood flow and high tumor pressure, which may prevent sufficient amounts of the inhibitor from reaching its target within the tumor.

The novel type of VEGFR-3 blocking antibody has an unprecedented mechanism of action, which was effective even at very high concentrations of the VEGF-C growth factor. Importantly, the authors showed that combined use of antibodies blocking growth factor binding VEGFR-3 dimerization provided not only an additive, but rather a synergistic inhibition.

"The new dimerization inhibitor unveils a biologically meaningful ration
'/>"/>

Contact: Kari Alitalo
kari.alitalo@helsinki.fi
358-505-003-572
University of Helsinki
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Major depression more than doubles risk of dementia among adults with diabetes
2. Obesity, Drinking a Double Threat to the Liver
3. De-Duplication, Compression and No Double Backups Required: AppAssure Releases the Fastest and Most Scalable Backup & Recovery Solution for Microsoft Hyper-V
4. Henry Ford Hospital atudy: Hepatitis C infection doubles risk for kidney cancer
5. Obesity and weight gain near time of prostate cancer surgery doubles risk of recurrence
6. Look Out KFC Double Down, IHOP Pancake Stacker & BK Mimosa - Freshii Launches Zero Calorie Menu with Elemental Sides
7. Radiation Risks Nearly Double for Younger CT Scan Patients
8. Medical costs of cancer have nearly doubled over the past 2 decades
9. U.S. Cancer Costs Double in Two Decades
10. Female-to-Male HIV Transmission Risk Doubles During Pregnancy
11. Pregnancy doubles HIV risk in men; first trial of a microbicide in pregnant women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A double block of blood vessels to starve cancerous tumors
(Date:8/20/2014)... B. E. Smith, the only full-service leadership solutions ... to lead a national chief operating officer ... Ore. The top executive search firm in ... more than 900 healthcare executives into organizations. , ... healthcare organization serving a population of more than 35,000 ...
(Date:8/20/2014)... Hope For The Warriors® is excited to announce ... in Washington, DC on Thursday, October 2, 2014 at ... the courage of our wounded service members, their families, ... Got Heart, Give Hope® Celebration will benefit Hope For ... sense of self, restoring the family unit, and restoring ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Inc. ... year on its 33rd annual Inc. 500|5000, an ... The list represents the most comprehensive look at ... entrepreneurs. Companies such as Yelp, Pandora, Timberland, Dell, ... names gained early exposure as members of the ...
(Date:8/20/2014)... Atlanta, GA (PRWEB) August 20, 2014 ... Data to healthcare, Jvion successfully predicted stage iii ... levels that, in some situations, approached 90%. A ... never been achieved in commercial or academic settings. ... and prevent all types of hospital-acquired conditions to ...
(Date:8/20/2014)... Ticketability.com has Theresa Caputo tickets for ... well-known medium has been thrilling many with her amazing ... cities, with tickets becoming available August 15. , Among ... Albany, Baltimore, Trenton, Erie, Buffalo, Philadelphia, Charlotte, Houston, New ... Diego. The medium’s fans can obtain Theresa Caputo tour ...
Breaking Medicine News(10 mins):Health News:Good Shepherd Health Care System Retains B. E. Smith to Recruit New COO 2Health News:Good Shepherd Health Care System Retains B. E. Smith to Recruit New COO 3Health News:Hope For The Warriors Announces Got Heart, Give Hope Celebration in Washington, DC 2Health News:Etransmedia Makes Exclusive List for the Eighth Consecutive Year in Inc. Magazine 2Health News:Etransmedia Makes Exclusive List for the Eighth Consecutive Year in Inc. Magazine 3Health News:Jvion Achieves Benchmark Accuracy in Pressure Ulcer Prediction 2Health News:Theresa Caputo Tour Tickets for Sale at Ticketability.com Cause a Buying Frenzy Among Customers Over Their Offering of Deeply Discounted Seats 2
... treatment mainstay for prostate cancer puts men at increased ... large observational study published in the// Sept. 20 Journal ... have high five-year survival rates, but they also have ... study author Nancy Keating, MD, MPH, assistant professor of ...
... Chile announced a tax on airline tickets to raise ... who cannot afford them//. ,Representatives from the five ... Ignacio Lula da Silva of Brazil, were present for ... Annan and former US President Bill Clinton also attended. ...
... are almost twice as likely to attempt suicide as non-Maori ... than other New Zealanders. ,The survey conducted by the ... the prevalence of mental disorders among different ethnic groups in ... including 2600 Maori. ,It was found that thirty percent ...
... Recent studies have revealed that increased levels of ... events// in healthy women according to Boston-based investigators. ... screening of lipoprotein(a) in the population as a ... with cardiovascular risk. Besides that most lipid-correcting therapies ...
... tested as an anticancer agent to treat breast cancer, supports ... ,Duchene muscular dystrophy is a disease characterized by ... According to earlier studies, the functional decline of "dystrophic" ... fiber size. ,The recent study conducted by Dr. ...
... (China): More than 200 children were taken ill after eating ... ,The 223 students were admitted to a hospital and are ... ,Students of Dianshi Town High School began reporting symptoms ... at their school Monday and were immediately hopitalised. ...
Cached Medicine News:Health News:Prostate Cancer Treatment Increases Risk of Diabetes and Heart Disease 2Health News:High lipoprotein Levels in women Linked to Cardiovascular Risk 2Health News:Anti-cancer drug may treat muscular dystrophy 2
(Date:8/19/2014)...  Northwest Biotherapeutics (NASDAQ: NWBO ) (NW ... for solid tumor cancers, announced today that the $17.5 ... 2014, has closed.  The three-year notes have a 5% ... of common stock.  The investors also have an option, ... additional 30% of these notes on the same terms. ...
(Date:8/19/2014)... Aug. 19, 2014  Tokyo-based Atonarp Inc. announced ... round led by Walden Riverwood Ventures with participation ... of Atonarp,s Smart Spectrometer technology platform, which will ... has targeted the oil & gas and healthcare ... are excited to partner with Atonarp in pursuing ...
(Date:8/19/2014)... 19, 2014 Avizia, Inc., a leading provider ... closed an equity financing round led by NextGen Angels ... new funding will be used to continue to fuel ... Avizia welcomes Edward Kennedy , CEO and president ... joins Leonard Kurtzman , CFO of newBrandAnalytics, who ...
Breaking Medicine Technology:NW BIO COMPLETES THE CLOSING OF ITS $17.5 MILLION CONVERTIBLE NOTE OFFERING 2NW BIO COMPLETES THE CLOSING OF ITS $17.5 MILLION CONVERTIBLE NOTE OFFERING 3Atonarp Inc. Raises $8M Series A Round Led by Walden Riverwood Ventures 2Avizia Closes Funding Round 2
Inquire...
... brings you into the new age of ... offer your patients immediate, long-term results for ... This injectable filler offers superior versatility for ... reconstructive treatments. Long-lasting, Radiesse saves time and ...
... HEMOCHRON Response is a whole ... to be used at the ... easy-to-read screen and data management ... ID options. QC and operator ...
... Revitol Cellulite Cream is a revolutionary ... eliminating inches. Revitol Cellulite Removal Cream permits ... problem areas. With Revitol you can rid ... Just apply the Cellulite Cream to your ...
Medicine Products: