Navigation Links
A different path to fat-related heart disease
Date:1/18/2011

levels of triglycerides, heart-damaging fats commonly associated with obesity and type 2 diabetes in humans. The disruption in cell membrane fat synthesis and consequent triglyceride fat accumulation added up to heart problems for flies short on PE-producing enzymes. Compared to their genetically normal counterparts, they were especially prone to cardiac arrest under stress and other heart problems.

Since overactive SREBP seems to be the cause of heart disease in this system, can it be targeted to reduce heart disease? The researchers addressed this question by inhibiting SREBP or its fat-synthesizing target genes through genetic manipulation. In doing so, they were able to restore fat balance and rescue PE-deficient flies from heart malfunction. These beneficial effects were also achieved by reducing SREBP in just the heart, rather than the whole fly. As a result, the flies were still obese, but their hearts functioned normally. These findings further underscore the importance of SREBP in excess fat-related heart diseases, like lipotoxic cardiomyopathy.

"Here we identified a new metabolic pathway that exhibits striking similarities to obesity- and diabetes-related heart failure in humans," explained Dr. Bodmer, professor and director of the development and aging program at Sanford-Burnham and senior author of the study. "This information might now allow us to interfere with the toxic effects of high fat in the heart by directly manipulating these genes in the heart muscle."


'/>"/>

Contact: Josh Baxt
jbaxt@sanfordburnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Ph.D. thesis shows why patients subjected to dialysis face their illness in different ways
2. Resistance Exercise May Offer Different Cardio Benefits
3. APHA 2010: Attacking the drinking culture on college campuses from different directions
4. Lung Cancer in Smokers, Nonsmokers May Be a Different Disease
5. Neuralstem stem cells survive and differentiate into neurons in rats with stroke
6. Institute for Aging Research study finds indoor and outdoor fall are different for the elderly
7. Scientists map epigenetic changes during blood cell differentiation
8. Breast cancer risk varies among different progestins used in hormone replacement therapy
9. Chemical system in brain behaves differently in cocaine addicts, UT Southwestern scientists find
10. Effective inducing systems of hepatic differentiation from bone marrow mesenchymal stem cells
11. Gene related to aging plays role in stem cell differentiation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... On Saturday, October 25, 2014, the Brownsville ... health and fitness fair ¡Vive tu vida! Get Up! Get ... nutrition for better health and wellness for people of all ... open to the public, will be held at Dean Porter ... to 1:00 pm. , “¡Vive tu Vida! Get Up! ...
(Date:10/22/2014)... 2014 Medical Solutions , ... happy to announce that our co-founder and CFO, ... Analysts’ Staffing 100 for 2014. Anderson was also ... influential people in the staffing industry,” in 2013.     ... 13th-largest healthcare staffing company in the U.S., was ...
(Date:10/22/2014)... October 22, 2014 For Dr. Iris Hunter, ... money; it’s an extension of her life’s mission. Her extensive ... as the owner of FirstLight HomeCare, make it clear that ... to me that my work makes a difference in the ... entrepreneurial spirit, so after much research, I felt ready to ...
(Date:10/22/2014)... TUESDAY, Oct. 21, 2014 (HealthDay News) -- The ... passengers arriving from Ebola-affected nations of West Africa ... screen them for infection with the virus. ... Jeh Johnson noted that 94 percent of air ... land at one of these five airports -- ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 The ... , which is dedicated to distribute health information ... healthcare delivery worldwide announced the development of six ... patients expect when receiving healthcare. These are an ... patient-centered care: “providing care that is respectful of ...
Breaking Medicine News(10 mins):Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 3Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:The Sullivan Institute for Healthcare Innovation Announces Release of Guiding Principles for Patient Experience-Centered Care 2
... nano-sensor for better detection of Mad Cow Disease agent, ... food safety, researchers in New York are reporting development ... of the deadly prion proteins that cause Mad Cow ... detects binding of prion proteins by detecting frequency changes ...
... Suracell,s Italian partner, DNA Research, officially launches Suracell ... international markets expected to open soon, SOUTH ... ), the leading provider of genetically directed,personalized age ... in,a series of worldwide partnerships to bring its ...
... Palomar Medical,Technologies, Inc. (Nasdaq: PMTI ), ... cosmetic treatments, earlier today announced that,it has entered ... &,Gamble Company (NYSE: PG ) to exploit ... new agreement, P&G retains a non-exclusive,license in the ...
... New streamlined pre-application process helps make sale of long-term care ... insurance ... Treaty Network,America Insurance Company (NYSE: PTA ) has developed ... determine whether,their clients qualify for long-term care insurance (LTCi)., ...
... Environment and Health & Beauty Get a New ... HowToDoThings.com, a,popular online destination that helps solve ... on diverse topics, celebrates the,world,s most popular bean ... in recognition of "Caffeine Awareness Month" in March.,HowToDoThings.com ...
... New information about food,and diet appears every day. ... personal endorsement of a trendy diet, news reports,about conflicting ... how do you,separate the truth from the fiction when ... Month(R), the American Dietetic Association,urges consumers to look beyond ...
Cached Medicine News:Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 2Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 3Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 4Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 5Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 6Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 7Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 8Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 9Health News:Anti-Aging/Genetic Health Leader Suracell, Inc. Expands Internationally 2Health News:Palomar Seeks to License Additional Companies to Home-Use Light-Based Hair Removal Technology 2Health News:Palomar Seeks to License Additional Companies to Home-Use Light-Based Hair Removal Technology 3Health News:Palomar Seeks to License Additional Companies to Home-Use Light-Based Hair Removal Technology 4Health News:Penn Treaty Introduces LTCi QuickPass(SM) Program 2Health News:HowToDoThings.com Brews Up New Uses for Coffee That Will Perk You Up in Recognition of March's 'Caffeine Awareness Month' 2Health News:During National Nutrition Month and Beyond, Find the Facts on Nutrition by Focusing on the Science 2
(Date:10/20/2014)... VIEW, California , 20 de octubre de ... líder en el campo de la pulmonología intervencional, ... su Estudio RENEW, casi 3 meses antes de ... fundamental de exención de dispositivo de investigación (IDE) ... Medicamentos) para el sistema de espiral de reducción ...
(Date:10/20/2014)... 2014  ResMed (NYSE: RMD ) ... Exchange program, a comprehensive suite of software and ... other health care providers. ResMed ... patient information. It integrates valuable sleep and respiratory ... management platforms with customers, in-house or third-party electronic ...
(Date:10/20/2014)... SAN DIEGO , Oct. 20, 2014 /PRNewswire/ ... development of therapeutic antibodies, today announced the appointment ... Development Officer. Dr. Londei will lead the preclinical ... "We are pleased to welcome ... Hamza Suria , President and Chief Executive ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3ResMed Launches ResMed Data Exchange 2AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
... 16, 2011 InspireMD, Inc. (OTC BB: NSPR) ... mesh protective stent system, today announced that it has ... 30, 2011 with the U.S. Securities and Exchange Commission. The ... Year-to-Date Highlights Year-to-date shipment volumes ...
... 2011 Beacon Enterprise Solutions Group, Inc. (OTC ... leader in the design, implementation and management of ... today announces the award from teaming partner ICS ... leading provider of innovative technologies and solutions, to ...
Cached Medicine Technology:InspireMD Provides Mid-Year Strategic Update 2InspireMD Provides Mid-Year Strategic Update 3InspireMD Provides Mid-Year Strategic Update 4InspireMD Provides Mid-Year Strategic Update 5InspireMD Provides Mid-Year Strategic Update 6InspireMD Provides Mid-Year Strategic Update 7Beacon Enterprise Solutions Announces $3.4 Million Contract Award With the Veteran's Administration 2Beacon Enterprise Solutions Announces $3.4 Million Contract Award With the Veteran's Administration 3
Unipolar Ventricular Lead...
The Petite leads are low profile (4.8F lead body diameter) implantable endocardial pacing leads which are manufactured using a new proprietary hexafilar coil for permanent stimulation of the ventricl...
Steroid-eluting, screw-in pacing lead...
... The Physique leads are small profile ... active-fixation helix. With a lead body size ... tip size of 7 F, the Physique ... lead available today. Available in both straight ...
Medicine Products: