Navigation Links
A culprit behind brain tumor resistance to therapy
Date:3/5/2012

Persistent protein expression may explain why tumors return after therapy in glioblastoma patients, according to a study published on March 5th in the Journal of Experimental Medicine.

Current therapy for glioblastoma, the most prevalent malignant brain tumor in adults, includes targeting a protein called VEGF, which promotes the growth of blood vessels to the tumor. Unfortunately, in most glioblastoma patients treated with anti-VEGF drugs, tumors return shortly after treatment.

Through an international collaboration, Jiri Bartek, Jeremy Rich, and colleagues now show that these recurring tumors express a perpetually activated form of the VEGF receptor. This active VEGF receptor drives growth of the tumor even when VEGF is blocked. Directly inhibiting the VEGF receptor, however, killed the tumors and extended the survival of tumor-bearing mice that were resistant to VEGF blockade.

These results suggest that blocking this active VEGF receptor may represent an alternative treatment option in glioblastoma cases where VEGF targeting has failed.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers identify breast cancer culprits
2. Lung cancer culprit could offer target for therapy, UT Southwestern researchers report
3. Key culprit identified in breast cancer metastasis
4. Researchers search for culprit behind dry eyes, mouths and more
5. New culprit found in Lou Gehrigs disease
6. Expert Panel Pinpoints Environmental Culprits in Breast Cancer
7. Extra Calories, Low Protein Are Culprits in Weight Gain
8. Researchers discover new culprit in atherosclerosis
9. New culprit discovered in T-cell acute lymphoblastic leukemia
10. Gene Might Be a Culprit in Sudden Infant Death for Boys
11. Low levels of natural antibodies behind stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... May 26, 2017 , ... Water damage to the flooring of several ... had left education officials with a number of critical issues to address before students ... to be accomplished with little or no disruption to class schedules. Second, the project ...
(Date:5/24/2017)... ... May 24, 2017 , ... In modern research, success depends ... instruments for research and understanding the basic principles that were designed to drive ... innovations in stereo microscopy for brightfield and fluorescence typically used in laboratories working ...
(Date:5/24/2017)... ... 24, 2017 , ... Altec Products, Inc., a leader in enterprise ... one-day technology conference in San Diego, CA. , At nVerge 2017, Altec will ... utilize and enhance their Sage ERP solutions by providing improved visibility and control to ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. ... NY, who have now spent 10 years as clinical instructors for the reputable ... College of Dentistry. Through the program, private practitioners receive cutting-edge clinical training and ...
(Date:5/24/2017)... ... , ... Patients who want to receive cosmetic dentistry procedures such as Invisalign® ... for a consultation, with or without a referral. Dr. Bedich enjoys improving the appearance ... , Dr. Bedich offers a variety of cosmetic dentistry services at his practice that ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... MARLBOROUGH, Mass., May 10, 2017 Hologic, Inc. ... financial results for the fiscal second quarter ended April ... (EPS) of $1.84 increased 666.7% compared to the prior ... business resulted in a significant gain, while non-GAAP diluted ... increased 3.2%, or 3.8% in constant currency terms.  Excluding ...
(Date:5/10/2017)... Md. , May 10, 2017 CSSi, ... solutions for the clinical research industry, is proud to ... www.CSSiEnroll.com . The new website features both enriched content ... user experience and enhances the company,s already well-established position ... industry. "After many months of hard ...
(Date:5/9/2017)... 9, 2017  Semler Scientific, Inc. (OTCQB: SMLR), ... to improve the clinical effectiveness and efficiency of ... first quarter ended March 31, 2017. ... customers to identify when preventive care options are ... like heart attacks or strokes occur," said ...
Breaking Medicine Technology: