Navigation Links
A culprit behind brain tumor resistance to therapy
Date:3/5/2012

Persistent protein expression may explain why tumors return after therapy in glioblastoma patients, according to a study published on March 5th in the Journal of Experimental Medicine.

Current therapy for glioblastoma, the most prevalent malignant brain tumor in adults, includes targeting a protein called VEGF, which promotes the growth of blood vessels to the tumor. Unfortunately, in most glioblastoma patients treated with anti-VEGF drugs, tumors return shortly after treatment.

Through an international collaboration, Jiri Bartek, Jeremy Rich, and colleagues now show that these recurring tumors express a perpetually activated form of the VEGF receptor. This active VEGF receptor drives growth of the tumor even when VEGF is blocked. Directly inhibiting the VEGF receptor, however, killed the tumors and extended the survival of tumor-bearing mice that were resistant to VEGF blockade.

These results suggest that blocking this active VEGF receptor may represent an alternative treatment option in glioblastoma cases where VEGF targeting has failed.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers identify breast cancer culprits
2. Lung cancer culprit could offer target for therapy, UT Southwestern researchers report
3. Key culprit identified in breast cancer metastasis
4. Researchers search for culprit behind dry eyes, mouths and more
5. New culprit found in Lou Gehrigs disease
6. Expert Panel Pinpoints Environmental Culprits in Breast Cancer
7. Extra Calories, Low Protein Are Culprits in Weight Gain
8. Researchers discover new culprit in atherosclerosis
9. New culprit discovered in T-cell acute lymphoblastic leukemia
10. Gene Might Be a Culprit in Sudden Infant Death for Boys
11. Low levels of natural antibodies behind stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... ... The Women’s Choice Award, a growing platform that gives a voice to ... Award. The identification by women of an effective new migraine relief product ... In a survey taken by the Women’s Choice Award organization, nine out of ten ...
(Date:8/22/2017)... ... August 22, 2017 , ... Western North Carolina’s only ... popular international aesthetics conference for medical professionals about the positive impact Juliet™ ... his growing practice. , Dr. George K. Ibrahim shared the results ...
(Date:8/22/2017)... ... ... six years, Lightning Labels has sent out a call for users of its custom label ... of their designs. Submissions this year were open from May 18 to July 1 and ... of the sixth annual Photo Contest, along with the prizes they've received:, ...
(Date:8/22/2017)... ... 2017 , ... Nurses at Apple Rehab Watch Hill , a nursing ... and certification in Closed Pulse Irrigation™ (CPI) for wound care. This qualifies ... Centers for Medicare and Medicaid Services, to have a CPI machine that will provide ...
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... “To Walk ... radioman on a B17 bomber named Edward Koontz. “To Walk Away” is the creation ... Scranton, who has published over two hundred manuscripts in chemistry and religion, as well ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... Ltd. (NASDAQ/TASE: BLRX), a clinical-stage biopharmaceutical company focused on ... the second quarter ended June 30, 2017. ... to date: Continued ... lead project, BL-8040: Announced plans to ... stem cell mobilization treatment for autologous bone-marrow transplantation in ...
(Date:8/7/2017)... Ind. , Aug. 7, 2017 Zimmer Biomet ... musculoskeletal healthcare, today announced that its Board of Directors has ... for the third quarter of 2017. ... be paid on or about October 27, 2017 to stockholders ... 22, 2017.  Future declarations of dividends are subject to approval ...
(Date:8/7/2017)... International plc (NASDAQ: ENDP ) today announced that ... U.S. mesh product liability claims and that it is ... claims at reasonable values. Under the agreements, Endo will ... 2017 and continuing through the fourth quarter of 2019. ... Company intends to increase its mesh product liability accrual ...
Breaking Medicine Technology: