Navigation Links
A common denominator of inflammations and fatty liver
Date:5/27/2008

Many cancer patients lose a lot of weight during their disease: Fat and muscle mass are reduced, free fatty acids accumulate in the liver, and this eventually leads to fatty liver in affected patients. What is called tumor cachexia appears to be caused by signals emitted by the tumor itself. Despite vigorous searching, scientists have not yet been able to identify these degradation signals of tumors. Therefore, a research team at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg, Germany, decided to take the opposite approach: Instead of searching for hunger signals in the tumor, they investigated the other end of the signaling chain: liver cells of mice affected by cancer. In the process, they discovered a molecular marker which controls both metabolic processes and inflammatory responses.

In advanced stages of cancer, particularly in pancreatic and lung cancers, patients frequently suffer from a wasting syndrome known as cancer cachexia. Affected patients grow very thin and weak, often there is a danger of organ failure. Body fat, in particular, is reduced and its accumulatation in the liver leads to fatty liver. This process seems to be caused by signals from the tumor itself, which radically direct metabolic processes in the body towards degradation and cause a state of chronic inflammation in the body. Despite intensive efforts to identify these signals, they remain unknown.

Stephan Herzig, head of the Emmy Noether and Marie Curie Junior Research Group Molecular Metabolic Control at DKFZ, and his co-workers have focused on the other end of the signaling chain: They studied liver cells of tumor-bearing mice showing signs of severe cancer cachexia. In particular, they searched for a molecule called RIP140, previously identified by Herzig as a regulator suppressing fat breakdown in the livers of healthy mice. Indeed, the investigators found a high activity of RIP140 in the cancerous mice and, accordingly, signs of fatty liver in these animals. When Herzig specifically switched off this molecule in the liver cells of tumor-bearing mice, the lipid balance of the liver normalized within a few days. The researchers have now published their results in Hepatology.

Apart from fatty liver, highly active immune cells are another characteristic of wasting in tumor patients: Increased levels of macrophages invade fatty or liver tissue and release messaging substances such as interleukin-6 and tumor necrosis factor-alpha. The result is an inflammatory response in these organs, which eventually contributes to a disruption of metabolism and loss of energy in affected patients. Collaboration partners of Stephan Herzig in London have bred mice that completely lack the RIP140 molecule. These animals are lean and stay lean, even on a rich diet. When the researchers in Herzigs group compared these animals to normal mice, they also found that their macrophages release only small amounts of proinflammatory messaging substances. The RIP140 molecule in these inflammatory cells exercises its effect through another master regulator: the NFkB transcription factor. These results have just been published in Blood.

Thus we have put another small link into the long unknown signaling chain from tumor to tumor cachexia, says Stephan Herzig, characterizing the relevance of his two papers. Now, of course, we will search for the activator of RIP140, Herzig explains. Thus, we will proceed from one link to the next until we arrive at the tumor. And, hopefully, find the hunger signal of tumors one day.


'/>"/>

Contact: Dr. Stefanie Seltmann
s.seltmann@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Mayo Clinic researchers find common gene disorder doubles risk of lung cancer, even among nonsmokers
2. PA ABC Will Benefit Commonwealths Small Businesses, DCED Secretary Says
3. Incidental adrenal masses commonly seen on CT are usually benign; no follow-up needed
4. Smallpox Drug May Protect Against Common Cold
5. Womens Health Crisis: GI Problems Common in Women
6. Study finds 21st birthday binge drinking extremely common; can pose serious health hazards
7. Depression, PTSD Common Among Lung Transplant Patient Caregivers
8. Melissa Biggs, Fashion Designer and Former Baywatch Actress, Teams with CSL Behring to Raise Awareness of Alpha-1 Antitrypsin Deficiency, a Commonly Misdiagnosed Respiratory Disease
9. Fibroids common, but women have options
10. Common Drug Eases Leg Pain From Walking
11. NightHawk Radiology Holdings, Inc. Announces Dutch Tender Offer for Its Common Stock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... ... As a former supermodel known for her timeless beauty, Joan Severance knows ... is that she put all the words in her new book, "Manifest Your Mate: ... and sparkling sense of humor have inspired her to write a book on how ...
(Date:4/24/2017)... ... 24, 2017 , ... Labs often perform the same operations ... operators and management to assess these processes with a critical eye—particularly in the ... , Created with the help of both internal and external process experts, ...
(Date:4/24/2017)... New York, NY (PRWEB) , ... April 24, ... ... students in 72 countries clearly shows that over the last decade, student well-being ... have ticked all the boxes of formal education, join the Islamic State to ...
(Date:4/24/2017)... ... ... “Learning to Use Your SPIRITUAL COMPASS To Navigate Life Issues”: a guide to using ... Life Issues” is the creation of published author, Rachel Jamerson, writer of 25 years, ... USA, and former member of the American Association of Christian Counselors. Rachel studied ...
(Date:4/24/2017)... ... 2017 , ... Miami Periodontist and Dental Implant ... Foundation’s 2017 Symposium on Tissue Regeneration and Implant Dentistry held in Miami Beach ... Symposium at the Fontainebleau Hotel located in Miami Beach, FL. This annual symposium ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Novartis today ... the National Heart, Lung, and Blood Institute (NHLBI) ... that 58% of patients with treatment-naïve severe aplastic ... when treated with eltrombopag at the initiation of ... The study evaluated three sequential treatment groups, or ...
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, Inc. ... providing the Urology, Uro/Gyn and Gynecology markets with innovative ... first quarter ended March 31, 2017 after the market ... The Company will host a conference call and webcast ... Tuesday, May 2, 2017 at 4:30 p.m. Eastern Time ...
(Date:4/18/2017)... DIEGO , April 18, 2017  Astute Medical, ... a case series to be presented at the 2017 ... which begins today and continues through April 22. Physicians ... IGFBP-7 , used to assess risk for acute kidney ... decompensated heart failure (ADHF). Elevated levels ...
Breaking Medicine Technology: