Navigation Links
A common denominator of inflammations and fatty liver
Date:5/27/2008

Many cancer patients lose a lot of weight during their disease: Fat and muscle mass are reduced, free fatty acids accumulate in the liver, and this eventually leads to fatty liver in affected patients. What is called tumor cachexia appears to be caused by signals emitted by the tumor itself. Despite vigorous searching, scientists have not yet been able to identify these degradation signals of tumors. Therefore, a research team at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg, Germany, decided to take the opposite approach: Instead of searching for hunger signals in the tumor, they investigated the other end of the signaling chain: liver cells of mice affected by cancer. In the process, they discovered a molecular marker which controls both metabolic processes and inflammatory responses.

In advanced stages of cancer, particularly in pancreatic and lung cancers, patients frequently suffer from a wasting syndrome known as cancer cachexia. Affected patients grow very thin and weak, often there is a danger of organ failure. Body fat, in particular, is reduced and its accumulatation in the liver leads to fatty liver. This process seems to be caused by signals from the tumor itself, which radically direct metabolic processes in the body towards degradation and cause a state of chronic inflammation in the body. Despite intensive efforts to identify these signals, they remain unknown.

Stephan Herzig, head of the Emmy Noether and Marie Curie Junior Research Group Molecular Metabolic Control at DKFZ, and his co-workers have focused on the other end of the signaling chain: They studied liver cells of tumor-bearing mice showing signs of severe cancer cachexia. In particular, they searched for a molecule called RIP140, previously identified by Herzig as a regulator suppressing fat breakdown in the livers of healthy mice. Indeed, the investigators found a high activity of RIP140 in the cancerous mice and, accordingly, signs of fatty liver in these animals. When Herzig specifically switched off this molecule in the liver cells of tumor-bearing mice, the lipid balance of the liver normalized within a few days. The researchers have now published their results in Hepatology.

Apart from fatty liver, highly active immune cells are another characteristic of wasting in tumor patients: Increased levels of macrophages invade fatty or liver tissue and release messaging substances such as interleukin-6 and tumor necrosis factor-alpha. The result is an inflammatory response in these organs, which eventually contributes to a disruption of metabolism and loss of energy in affected patients. Collaboration partners of Stephan Herzig in London have bred mice that completely lack the RIP140 molecule. These animals are lean and stay lean, even on a rich diet. When the researchers in Herzigs group compared these animals to normal mice, they also found that their macrophages release only small amounts of proinflammatory messaging substances. The RIP140 molecule in these inflammatory cells exercises its effect through another master regulator: the NFkB transcription factor. These results have just been published in Blood.

Thus we have put another small link into the long unknown signaling chain from tumor to tumor cachexia, says Stephan Herzig, characterizing the relevance of his two papers. Now, of course, we will search for the activator of RIP140, Herzig explains. Thus, we will proceed from one link to the next until we arrive at the tumor. And, hopefully, find the hunger signal of tumors one day.


'/>"/>

Contact: Dr. Stefanie Seltmann
s.seltmann@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Mayo Clinic researchers find common gene disorder doubles risk of lung cancer, even among nonsmokers
2. PA ABC Will Benefit Commonwealths Small Businesses, DCED Secretary Says
3. Incidental adrenal masses commonly seen on CT are usually benign; no follow-up needed
4. Smallpox Drug May Protect Against Common Cold
5. Womens Health Crisis: GI Problems Common in Women
6. Study finds 21st birthday binge drinking extremely common; can pose serious health hazards
7. Depression, PTSD Common Among Lung Transplant Patient Caregivers
8. Melissa Biggs, Fashion Designer and Former Baywatch Actress, Teams with CSL Behring to Raise Awareness of Alpha-1 Antitrypsin Deficiency, a Commonly Misdiagnosed Respiratory Disease
9. Fibroids common, but women have options
10. Common Drug Eases Leg Pain From Walking
11. NightHawk Radiology Holdings, Inc. Announces Dutch Tender Offer for Its Common Stock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... 02, 2016 , ... Dr. Raffi Hovsepian, a leading plastic, ... 2016 “Guide to America’s Top Plastic Surgeons” for seven consecutive years. The prestigious ... experience, and professional associations. , One the most frequently honored surgeons in ...
(Date:12/2/2016)... ... December 02, 2016 , ... The PAINWeekEnd Regional ... Resort and Spa in Honolulu, offering local frontline clinicians the opportunity to extend ... , The demand for supplemental training related to pain management has surged dramatically ...
(Date:12/2/2016)... , ... December 02, 2016 , ... Yisrayl Hawkins, at ... into how this current generation fits into Bible Prophecy. Yisrayl says this generation, known ... pointing to this conclusion, showing how the details line up exactly with Bible Prophecy ...
(Date:12/2/2016)... ... 2016 , ... Today CloudMine, a secure, cloud-based platform that ... best Sales Team of 2016 as part of the 2016 SIIA Company CODiE ... & Information Industry Association (SIIA), the principal trade association for the software and ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... a comprehensive in-house dental plan for all patients. Understanding that budget can play ... gives patients a number of perks, including discounts on many valuable dental treatments. ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... - bioLytical lanza el INSTI HIV Self Test para el mercado ... Continue Reading ... New: INSTI Self Test! ... , bioLytical Laboratories (la "Compañía"), un líder mundial ... lanzamiento de su INSTI HIV Self Test  a África con una versión de ...
(Date:12/2/2016)... According to the latest market report published by ... Reprocessors: Single Basin Automated Endoscope Reprocessors Product Type Segment Anticipated ... the global automated endoscope reprocessors market was valued at US$ 740.6 Mn ... of 7.2% during an eight-year forecast period 2016-2024, to reach ... ...
(Date:12/2/2016)... -- In the first ever attempt to include phytocannabinoids ... C. sativa, the Hebrew University in Jerusalem, the University ... , the Universita` del Piemonte Orientale and Phytoplant Research ... unified inventory of phytocannabinoids of different botanical origin. ... chemical and structural diversity of phytocannabinoids. As a result ...
Breaking Medicine Technology: