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A combination therapy of 3 vasodilators may treat portopulmonary hypertension
Date:3/4/2008

equences, the authors conclude.

An accompanying editorial by Karen Swanson of the Mayo Clinic writes, It is easy to see why combination therapy may make sense as we do not yet have a means of determining which predominant mechanism is influencing which patient and, which medications might be most beneficial specifically in POPH.

She laments the fact that POPH is excluded from every clinical trial involving pulmonary hypertension, especially given its prevalence, and worries about the cost of triple-drug therapy when we dont even have good prospective data on individual drug therapy.

Only by following multi-center prospective protocols in POPH will we ever have more meaningful answers to the ideal course of treatment in these patients, she concludes. Until then, we continue to extrapolate our thoughts from single center case reports and case series. Can we move on?


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Contact: Amy Molnar
amolnar@wiley.com
Wiley-Blackwell
Source:Eurekalert

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