Navigation Links
A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
Date:9/4/2007

COLD SPRING HARBOR, N.Y. (Tues., Sept. 4, 2007) Skin cancer is the most prevalent form of human cancer in the United States, according to the Centers for Disease Control. But in order to more fully understand skin cancer in humans, scientists must use model organisms, such as mice, to study the disease in the laboratory.

This months release of Cold Spring Harbor Protocols (www.cshprotocols.org) includes free access to a protocol for generating mice with squamous cell carcinoma (SCC), one of the most common types of skin cancer. The procedure involves injecting mice with a drug called DMBA, which mutates (and thereby activates) a tumor-promoting gene. A second drug, called TPA, then encourages the proliferation of cells that carry the mutated gene. The resulting mass of cells is a tumor.

The protocol, freely available at http://www.cshprotocols.org/cgi/content/full/2007/18/pdb.prot4837, describes how to monitor and evaluate the mice for clinical signs of tumorigenesis. It also includes methods for preparing the tumor tissues for histological analysis, which allows scientists to study characteristics of the tumors at a microscopic level.

The protocol is from Dr. Michael Girardis group at the Yale University School of Medicine (http://info.med.yale.edu/dermatology/dept/girardi.html). Girardis team has used the procedure to examine the role of the immune system in susceptibility to SCC. It can also be used to test other physiological and environmental factors that may influence the growth and progression of skin cancer in mice, and will ultimately help scientists to better understand and control the disease in humans.

Also freely available from Cold Spring Harbor Protocols this month is an article that describes an
'/>"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Ultrasound may mean end to classic stethoscope
2. New methods to prevent injury of patients
3. A new method to help smokers quit
4. Methods to have a flat stomach
5. Bioengineering production strains - Microbia develops new methods
6. New method of measuring arterial stiffness in elderly hypertensives
7. Easier Methods Required to Screen Insulin Resistance
8. Easier Methods Required to Screen Insulin Resistance
9. Accuracy of Some Natural Family Planning Methods Questioned .
10. New Method Of Delivering Chemotherapy
11. Adopting Easier Methods To Screen Insulin Resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (PRWEB) July 12, 2014 Recently, MagicQuinceaneraDresses.com, ... released its new collection of 2014 Quinceanera dresses ... those who want to look fashionable without paying a ... discounted prices, up to 57% off. , The company’s ... ladies to get amazing special occasion outfits. In addition ...
(Date:7/11/2014)... 2014 Recently, DressyQuinceanera.com, a well-known wedding ... Dama dresses to its online category. Furthermore, the ... at deeply discounted rates, up to 62% off. , ... equally excellent in terms of quality and style. All ... discounts are also offered for the company’s other items: ...
(Date:7/11/2014)... 2014 The American Association of Poison ... centers are commending Senator Bill Nelson (D-FL) for his ... 2014 on July 10, 2014. Along with fellow Senate ... Commission (CPSC) to enact rules requiring safer, child-resistant packaging ... , Senate co-sponsors of the bill include: Sen. Richard ...
(Date:7/11/2014)... According to new report "C4ISR Market ... to register a CAGR of 2.28% to reach ... data tables and 76 figures spread through 185 ... http://www.marketsandmarkets.com/Market-Reports/c4isr-market-1315.html , Early buyers will receive 10% ... The report provides market analysis of the global ...
(Date:7/11/2014)... 2014 Ticket Down reports that tickets to ... 3rd place World Cup Match between Brazil and Netherlands ... take place on Saturday, July 12th at Estadio Nacional de ... will take place on Sunday, July 13th at Estadio Jornalista ... tickets for the 2014 World Cup are guaranteed to be ...
Breaking Medicine News(10 mins):Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:DressyQuinceanera.com: Beautiful Quinceanera Dama Dresses At Low Prices 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 3Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2
... 8 The Integrated,Healthcare Association (IHA) welcomes Leah ... annual National Pay for Performance Summit at the,Beverly ... is the,leading forum on pay for performance to ... Group has made outstanding contributions toward the,improvement of ...
... - code situations in hospital parlance - easily expose common ... for children and also set up powerful incentives to ... a study from the Johns Hopkins Childrens Center. , ... and published in the January issue of Pediatrics, found sometimes ...
... GOVERNOR AT RECEPTION 5:30 PM WED., FEB. 13 AT ... CHAMBER, WVAADC, LEGISLATIVE LEADERS, AND CRC HEALTH GROUP ... 8 Four-Star General,Barry McCaffrey (ret.), the former White ... policy expert in the national media, will,spearhead a Feb. ...
... Amscot Financial, a leading,provider of convenient, consumer-oriented ... fun "the Amscot way" at its open house ... at 3260 Vineland Road in Kissimmee. Amscot,will present ... of the,Juvenile Diabetes Research Foundation, which underwrites efforts ...
... woman who collapsed and died shortly after arriving for her ... first reported death to be reported nationally from acute asthma ... by a Michigan State University physician, published in the February ... outlines circumstances under which the woman died, but also raises ...
... Chefs Help Raise Awareness and $50,000 for UNICEF, ... Burke, Paul,Prudhomme and Michael Symon are among eleven ... Idaho Potato Commission,s "Recipes for Relief",on-line program. The ... the United,Nation,s declaration of 2008 as the International ...
Cached Medicine News:Health News:Integrated Healthcare Association Welcomes Leah Binder, New CEO of Leapfrog Group to National Pay for Performance Summit 2Health News:Mock CPR 'codes' expose weaknesses in hospital emergency response for children 2Health News:4-Star Gen. Barry McCaffrey, Former U.S. Drug Czar, and Dr. Barry Karlin, Nation's #1 Drug Treatment Provider, to Spearhead Drug Treatment WVA Advocacy Day Feb 13-14; 142,000 Need, Don't Get Treatment in State 2Health News:Amscot Financial Contributes to the Juvenile Diabetes Research Foundation, Supporting Upcoming 'Walk for a Cure' 2Health News:Case links death to environmental tobacco smoke 2Health News:Idaho Potato Commission Launches 'Recipes for Relief' in Celebration of the International Year of the Potato 2Health News:Idaho Potato Commission Launches 'Recipes for Relief' in Celebration of the International Year of the Potato 3Health News:Idaho Potato Commission Launches 'Recipes for Relief' in Celebration of the International Year of the Potato 4
(Date:1/15/2014)... 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) ... support, China,s orthopedic instrument industry ... market size rising from 3.28 billion yuan in 2006 ...
(Date:1/15/2014)... 2014 As health officials across the Midwest warn against ... in Michigan will offer free diagnostic ... Meijer pharmacists to administer tests and, in some cases, fill ... participating in the study. The Grand ...
(Date:1/15/2014)... Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... from institutional investors to purchase an aggregate of approximately ... at-the-market registered direct offering, led by a dedicated health ... purchase agreements with these investors pursuant to which the ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... the industry-leading portal to QC information, providing ... way to access their quality control data ... Internet. UnityWeb enables Bio-Rad customers to access ... as well as convenient online data entry ...
... self-adhesive insulin pod that you fill with insulin ... to three days and then replace. The OmniPod ... body through a small flexible tube (called a ... its wireless companion, the Personal Diabetes Manager. The ...
Inquire...
SPR treats pigmented and vascular lesions, skin aging, sun damaged skin and fine lines and wrinkles with clinically proven LHE technology....
Medicine Products: