Navigation Links
A civil war inside our cells: Scientists show how our bodies fight off 'jumping genes'
Date:4/25/2014

ANN ARBOR, Mich. There's a civil war going on inside every one of the 37 trillion cells in your body. Now, University of Michigan scientists have uncovered how your cells keep this war from causing too much collateral damage.

On one side of the battle: your "regular" DNA, which provides the day-to-day instructions for life. On the other side: tiny bits of rogue DNA that hide like spies between genes in your own DNA. From time to time, these rogue bits of DNA spin off a copy of themselves and "jump" to another DNA location often causing harmful mutations when they land.

How our cells fight off the effects of these rogue DNAs, called LINE-1 retrotransposons, has remained a mystery. But in a new paper published in the open-access journal eLife, scientists from the University of Michigan Medical School and Howard Hughes Medical Institute and colleagues have captured the action like battlefield reporters.

They zeroed in on the defensive activity of an enzyme called APOBEC3A and showed that it can cause mutations within the LINE-1 retrotransposons as they jump to new locations. This prevents subsequent invasions into other areas of DNA.

This defensive strike sends out a signal to other defense forces inside the cell, which neutralize the jumping gene and sweep away the destroyed copy.

The findings not only help explain a mystery of the body they also may help in the development of cancer drugs. That's because other APOBEC enzymes cause cancer-related mutations a kind of "friendly fire" that makes these enzymes a potential target for new drugs.

The new findings about APOBEC3A's ability to squelch LINE-1 activity could mean that blocking APOBEC3 with new cancer drugs might carry consequences.

John Moran, Ph.D., the U-M and HHMI geneticist who led the work with Sandra Richardson, Ph.D., says the new finding gives scientists the first proof of a hypothesized defense strategy.

"It's
'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Modern Civilization Could Vanish Due to Poor Water Conservation Warns Author
2. Female Veterans Leaving the Military Can Get Help Finding Civilian Careers with Career Confidential’s Mission: Transition Job Kit
3. Civilians trained by American mental health professionals bring healing to traumatized victims of Libyas civil war, Baylor study finds
4. Study: Many evangelicals are ambivalent about homosexuality and civil unions for gays
5. Net Worth TV Preparing a Segment about How to Protect Corporate Assets during Civil Unrest
6. The GEO Group, Inc. Receives 2013 Most Valuable Employers for Military® Award by CivilianJobs.com
7. ONR-funded software boosts marines civilian operations at fleet exercise
8. Study explores the impact of corruption and military organization on civilians
9. Following a proteins travel inside cells is key to improving patient monitoring, drug development
10. Neuroimaging: Live from inside the cell
11. Stem cells inside sutures could improve healing in Achilles tendon injuries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... In honor of National Drug Facts ... drug and alcohol abuse in schools and communities across ... with information on some of the dangers and statistics ... National Institute on Drug Abuse, this annual promotion of ... the illusions that teens and young adults get from ...
(Date:3/5/2015)... 05, 2015 Califia Farms , ... the natural products coffee drinks category[1], today unveils its ... West in Anaheim, Calif. Concentrated Cold Brew (CCB) ... Café, which democratizes the next wave of the coffee-taste ... need to become their own baristas. , Califia ...
(Date:3/5/2015)... York, NY (PRWEB) March 05, 2015 ... orthopedic Surgeon ( http://www.orthopedicsurgeonnyc.com ) has been named by ... the New York Metro area. Dr. Glashow has been ... its authoritative guide to the top specialty care doctors ... , The prestigious Castle Connolly program, which carefully screens ...
(Date:3/5/2015)... Nutrition Leaders, a premier purveyor of health, diet, ... Millennium 500 Creatine to its customers. Available from the ... creatine supplement that has been micronized to more quickly ... overall strength gains in users. , Creatine is a ... source in the body and helps fuel muscle contractions ...
(Date:3/5/2015)... 05, 2015 Wimbledon Health Partners ... vascular, echocardiogram and NCV testing, announced the ... Chief Medical Officer. Dr. Artel will be responsible for ... the WimbledonMED program and the continued growth and support ... working with Wimbledon Health Partners as a consulting physician ...
Breaking Medicine News(10 mins):Health News:A Forever Recovery Issues New Tips for Sobriety for National Drug Facts Week 2Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 2Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 3Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 4Health News:Dr. Jonathan Glashow, NYC Orthopedic Surgeon, Named Top Doctor: New York Metro Area 2Health News:Nutrition Leaders Offers Reformulated Millennium 500 German Grade Creatine 2Health News:Wimbledon Health Partners Appoints Chief Medical Officer to Attain Medicare Market Share 2Health News:Wimbledon Health Partners Appoints Chief Medical Officer to Attain Medicare Market Share 3
... in a Queen,s University-led study do not have an influenza ... tested. In addition, key players were not involved in developing ... not good enough just to have a plan, you have ... will work in an emergency," says Dick Zoutman, Queen,s professor ...
... , AKRON, Ohio , Feb. 10 ... is launching its first bachelor,s degree programs in its 40-year ... Administration with a Business Management concentration Bachelor of Science ... Information Management Bachelor of Science – Technology Management with ...
... or GAD, have abnormalities in the way their brain unconsciously ... School of Medicine study, and the study authors say the ... our understanding of how emotion is regulated in everyday life. ... American Journal of Psychiatry. According to the National ...
... ... celiac disease, one of the most common and under-diagnosed autoimmune diseases, it,s symptoms, and how ... a year, one being day-time Emmy Award winner, Elisabeth Hasselbeck of ABC’s “The View”. ... (PRWEB) February 11, 2010 -- ...
... removal of tumors, study found , WEDNESDAY, Feb. 10 (HealthDay ... levels of spiritual thinking and feeling in patients, a finding ... and the physical makeup of the mind, researchers say. , ... Neuron , are based on research in patients who had ...
... , , PUYALLUP, Wash. , ... IT stimulus and the American Recovery and Reinvestment Act ... comprehensive digital imaging and data management integration project with ... paying dividends for MINW patients even after the completion ...
Cached Medicine News:Health News:Akron Institute of Herzing University Launches Its First Bachelor's Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT 2Health News:Akron Institute of Herzing University Launches Its First Bachelor's Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT 3Health News:People with anxiety disorder less able to regulate response to negative emotions, study shows 2Health News:People with anxiety disorder less able to regulate response to negative emotions, study shows 3Health News:Multi-Award Winning Author Tina Turbin Interviews Special Guest Dr. Peter H.R. Green, M.D. On The Thrive in Balance Radio Show 2Health News:Physical Changes in Brain Linked to Altered Spirituality 2Health News:Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements 2Health News:Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements 3
(Date:3/5/2015)... SEATTLE und TÜBINGEN, Deutschland, 5. ... Melinda Gates Stiftung und das deutsche biopharmazeutische ... Stiftung 46 Millionen Euro (52 Millionen US-Dollar) ... im Bereich der medizinisch angewandten Messenger-RNA (mRNA). ... neue Ansätze zur Behandlung von Krankheiten und ...
(Date:3/5/2015)... 5, 2015  As the pharmaceutical industry works ... & Compliance professionals are placing a significant emphasis ... issued today by LRN, the leader in Ethics ... majority of respondents expressed that clarity on company ... of E&C training programs (57%), trumping understanding of ...
(Date:3/5/2015)... , March 5, 2015 Bayer HealthCare announced ... the Conquer Cancer Foundation of the American Society of ... health information technology platform designed to unlock vast quantities ... cancer.  "Bayer is proud to join ... to leverage Big Data to help people whose lives ...
Breaking Medicine Technology:Bill & Melinda Gates Stiftung investiert in CureVac zur Entwicklung innovativer Impfstoffe 2Bill & Melinda Gates Stiftung investiert in CureVac zur Entwicklung innovativer Impfstoffe 3Bill & Melinda Gates Stiftung investiert in CureVac zur Entwicklung innovativer Impfstoffe 4Pharmaceutical Ethics & Compliance Professionals Place Company Values Front and Center 2Pharmaceutical Ethics & Compliance Professionals Place Company Values Front and Center 3Bayer HealthCare Contributes $1 Million to Support Cancer Care Technology Platform 2Bayer HealthCare Contributes $1 Million to Support Cancer Care Technology Platform 3
... Sangart, Inc., a global biopharmaceutical company dedicated to ... perfusion and oxygenation of ischemic (oxygen deprived) tissues ... announced that its investigational biopharmaceutical product, MP4CO, has ... Food and Drug Administration (FDA) for use in ...
... health record (EHR) safety reporting system was announced today ... medical society and professional liability carrier executives in collaboration ... establishes a national system where physicians and other health ... and use of EHRs. Using a ...
Cached Medicine Technology:Sangart, Inc. Receives U.S. Orphan Drug Designation for use of MP4CO in Patients with Sickle Cell Disease 2Sangart, Inc. Receives U.S. Orphan Drug Designation for use of MP4CO in Patients with Sickle Cell Disease 3New National Electronic Health Record Safety System Launched 2New National Electronic Health Record Safety System Launched 3New National Electronic Health Record Safety System Launched 4New National Electronic Health Record Safety System Launched 5New National Electronic Health Record Safety System Launched 6
The Mini Vidas is a compact version of the Vidas system with a built-in computer, keyboard and printer. Two independent sections each accept six tests and can process up to 12 samples simultaneously....
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: