Navigation Links
A circuitous route to therapy resistance
Date:6/26/2013

Gliomas are malignant brain tumors that arise from glial cells called astrocytes, found in the central nervous system. "In treating malignant gliomas, we currently combine radiotherapy with the anticancer drug temozolomide. However, in some patients, tumors rapidly become resistant to both treatment methods," says neurooncologist Professor Dr. Michael Platten, who leads a cooperation unit of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Department of Neurooncology of Heidelberg University Hospital. "We therefore urgently need new methods of treating these diseases more effectively."

Chemotherapy and radiotherapy damage the DNA of tumor cells. Normally these DNA defects automatically trigger the cellular suicide program known as apoptosis. However, tumor cells possess an efficient DNA repair system that they use to protect themselves from the consequences of therapy, thus evading cell death.

Key repair mechanisms in the cell can only work efficiently if a molecule called NAD+ is present. When DNA repair is running at full throttle, as is the case during radiation therapy, NAD+ supplies are quickly exhausted in a cancer cell, leading to DNA damage that goes unrepaired and ultimately cell death. Cancer researchers are therefore trying to use drugs to deprive cells of NAD+ to prevent resistance to therapies. Substances that inhibit the enzyme which produces NAD+ are already being tested in clinical trials.

However, cells can produce NAD+ in a number of ways. They can synthesize it directly, or use a substance called quinolinic acid, a metabolite of the protein building-block tryptophan, as an alternative source to produce NAD+. Michael Platten and his team had discovered that malignant gliomas contain large amounts of quinolinic acid. "We wanted to know whether gliomas might use this circuitous route in order to produce enough NAD+ and thus escape therapy," says neuropathologist Felix Sahm, first au
'/>"/>

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Employee Wellness Challenge Get Fit on Route 66 Has New Mobile App, Announces Health Enhancement Systems
2. Federal Safe Routes to School program reduces child injuries by more than 40 percent in New York City
3. Auto-immune disease: The viral route is confirmed
4. A new route for tackling treatment-resistant prostate cancer
5. New roadmap suggests proven routes to ending health disparities
6. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
7. Novel drug candidates offer new route to controlling inflammation
8. Vein Therapy News Magazine Publishes Laser Facelift Article by Dr. Robin Fleck
9. Rural women less likely to get radiation therapy after lumpectomy for breast cancer
10. New understanding of why anti-cancer therapy stops working at a specific stage
11. Past Life Regression Therapy: Valid Treatment or Ridiculous Foo Foo; Researcher and Author Dr. Heather Friedman Rivera on Dr. Carol Francis Radio Talk Show
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/2/2014)... KY (PRWEB) August 02, 2014 ... Lakeview Estates neighborhood on Lexington’s southeast side, has undertaken ... a little better in the “green” sense, while improving ... Brad Rose, Lakewood Park’s property manager, announced that Lakewood ... its tenants. “We’re really excited about being able ...
(Date:8/2/2014)... August 02, 2014 CEDR HR ... number one provider of customized medical and dental employee ... dental-industry conferences this fall. CEDR’s CEO will be featured ... and early December. , From September 4-6, CEDR will ... Managers (AADOM) Dental Managers Conference in San Diego, to ...
(Date:8/1/2014)... (PRWEB) August 02, 2014 The successful ... the stamping business of Guangdong FODAY Automobile Co.,LTD. As ... the company had already organized an excellent team to ... number of detailed, in-depth technical plans. The company’s vice ... were in the direct involvement of the specific arrangement ...
(Date:8/1/2014)... The Judicial Panel on Multidistrict Litigation ... therapy caused strokes, heart attacks, and other injuries in ... F. Kennelly as the transferee judge and ordered what ... federal court. , As one of his first organizing ... of attorneys who will move the litigation forward on ...
(Date:8/1/2014)... appetite and whole-body metabolism. A protein known as PPARγ ... and body weight, but the identity of the neurons ... new study in the Journal of Clinical Investigation ... neuron known as pro-opiomelanocortin (POMC) neurons is critical in ... and colleagues at Yale University School of Medicine found ...
Breaking Medicine News(10 mins):Health News:Lexington’s Lakewood Park Apartments Getting Into Gardening 2Health News:Nuanced Media Client, CEDR HR Solutions, to Speak at Upcoming Major Dental Conferences 2Health News:Nuanced Media Client, CEDR HR Solutions, to Speak at Upcoming Major Dental Conferences 3Health News:FODAY Automobile Company Is Now Working On The C60F FODAY Project 2Health News:Judge Kennelly Appoints Attorney Michelle Kranz to the Plaintiffs’ Executive Committee in the Testosterone Replacement Therapy MDL 2
... University shows for the first time that the brain ... food and drugs - offering insights into our propensity ... boxing and football. , The research will be published ... Psychopharmacology. , Aggression occurs among virtually all vertebrates and ...
... Routing cue works like a Zip code helps deliver mail, ... researchers have found a way to modify the surface of ... advance that may prove useful in many areas of stem ... at Brigham and Women,s Hospital in Boston modified the surface ...
... $25.5 Million Investment in Detroit - Opens Thursday, DETROIT, ... of Detroit Mercy will be opening a new School of ... giving back to,the City of Detroit. The new wireless facility ... country., Over 261,000 square feet, the School,s new location ...
... Recognising people, objects or animals by the sound they make ... take for granted. But very similar objects can physically make ... subtle clues about the identity and source of the sound. ... (BBSRC) are working out how the human ear and the ...
... into ,skeleton, of animal organ was beating in just ... An organ-building biotechnology that could create transplantable hearts using ... laboratory tests, researchers report. , The technique, called whole ... tissue, according to a report in the Jan. 13 ...
... Fortune 500 Executive Driving Global Breast Cancer Leader,s Promise ... Quickly, End Breast Cancer Forever, ATLANTA, Jan. 12 ... Cure, the global leader in the fight to end breast,cancer ... the,16th annual Trumpet Awards event in Atlanta with a ,High ...
Cached Medicine News:Health News:Aggression as rewarding as sex, food and drugs 2Health News:Stem Cells Modified to Home in Where They're Needed 2Health News:University of Detroit Mercy School of Dentistry Moves to Larger Facility on New Corktown Campus 2Health News:University of Detroit Mercy School of Dentistry Moves to Larger Facility on New Corktown Campus 3Health News:Lend me your ears -- and the world will sound very different 2Health News:Biotechnology Builds a New Heart 2Health News:Biotechnology Builds a New Heart 3Health News:Susan G. Komen for the Cure's CEO Hala Moddelmog Earns 'High Heels in High Places' Recognition at 2008 Trumpet Awards 2Health News:Susan G. Komen for the Cure's CEO Hala Moddelmog Earns 'High Heels in High Places' Recognition at 2008 Trumpet Awards 3
(Date:8/1/2014)... , August 1, 2014 ... by Type (Traditional Wound Closure, Anti infective), Basic (Films, ... Skin & Skin Substitutes), Pressure Relief Devices, NPWT) ... global Wound Care Market is expected to reach ... 2014, growing at a CAGR of 3.2% from ...
(Date:8/1/2014)... Pa. , Aug. 1, 2014 Inovio ... will host a conference call to report its second ... at 9:00 AM ET. CEO Dr. J. Joseph ... discuss second quarter earnings, provide a corporate update, and ... will include clinical development plans for VGX-3100, Inovio,s immune ...
(Date:7/31/2014)... 2014  According to data released today by the ... monthly Medicare Part D premium is expected to remain ... originally projected, the Pharmaceutical Care Management Association (PCMA) said. ... be a bright spot in American health care. By ... and using cutting edge, cost-saving tools like pharmacy networks ...
Breaking Medicine Technology:Wound Care Market Worth $18.3 Billion by 2019 2Wound Care Market Worth $18.3 Billion by 2019 3Inovio Pharmaceuticals to Host Second Quarter 2014 Financial Results Call on August 11, 2014 2Inovio Pharmaceuticals to Host Second Quarter 2014 Financial Results Call on August 11, 2014 3
Head-worn Loupe G3, Galilean teleloupe system....
... The XL Advantage delivers higher magnification for ... crisp, true image, even at the highest ... edge clarity and precise color rendition is ... with an anti-reflective coating produce a superior ...
... The XL Advantage delivers higher magnification ... a crisp, true image, even at the ... to edge clarity and precise color rendition ... treated with an anti-reflective coating produce a ...
... higher magnification for advanced surgical procedures. Prismatic ... at the highest magnification. 3.5x, 4.5x and ... color rendition is ideal for surgical applications. ... produce a superior image. The compact abd ...
Medicine Products: