Navigation Links
A circuitous route to therapy resistance
Date:6/26/2013

Gliomas are malignant brain tumors that arise from glial cells called astrocytes, found in the central nervous system. "In treating malignant gliomas, we currently combine radiotherapy with the anticancer drug temozolomide. However, in some patients, tumors rapidly become resistant to both treatment methods," says neurooncologist Professor Dr. Michael Platten, who leads a cooperation unit of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Department of Neurooncology of Heidelberg University Hospital. "We therefore urgently need new methods of treating these diseases more effectively."

Chemotherapy and radiotherapy damage the DNA of tumor cells. Normally these DNA defects automatically trigger the cellular suicide program known as apoptosis. However, tumor cells possess an efficient DNA repair system that they use to protect themselves from the consequences of therapy, thus evading cell death.

Key repair mechanisms in the cell can only work efficiently if a molecule called NAD+ is present. When DNA repair is running at full throttle, as is the case during radiation therapy, NAD+ supplies are quickly exhausted in a cancer cell, leading to DNA damage that goes unrepaired and ultimately cell death. Cancer researchers are therefore trying to use drugs to deprive cells of NAD+ to prevent resistance to therapies. Substances that inhibit the enzyme which produces NAD+ are already being tested in clinical trials.

However, cells can produce NAD+ in a number of ways. They can synthesize it directly, or use a substance called quinolinic acid, a metabolite of the protein building-block tryptophan, as an alternative source to produce NAD+. Michael Platten and his team had discovered that malignant gliomas contain large amounts of quinolinic acid. "We wanted to know whether gliomas might use this circuitous route in order to produce enough NAD+ and thus escape therapy," says neuropathologist Felix Sahm, first au
'/>"/>

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Employee Wellness Challenge Get Fit on Route 66 Has New Mobile App, Announces Health Enhancement Systems
2. Federal Safe Routes to School program reduces child injuries by more than 40 percent in New York City
3. Auto-immune disease: The viral route is confirmed
4. A new route for tackling treatment-resistant prostate cancer
5. New roadmap suggests proven routes to ending health disparities
6. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
7. Novel drug candidates offer new route to controlling inflammation
8. Vein Therapy News Magazine Publishes Laser Facelift Article by Dr. Robin Fleck
9. Rural women less likely to get radiation therapy after lumpectomy for breast cancer
10. New understanding of why anti-cancer therapy stops working at a specific stage
11. Past Life Regression Therapy: Valid Treatment or Ridiculous Foo Foo; Researcher and Author Dr. Heather Friedman Rivera on Dr. Carol Francis Radio Talk Show
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... , FRIDAY, March 4 (HealthDay News) -- Many parents ... the high cost of raising children, new research suggests. ... least one child under age 18. The Canadian researchers had ... by having them read a government document estimating that it ...
... invited to apply for travel awards to send their ... to be held July 3-7, 2011 in Amsterdam. ... (IASLC) will grant awards to five different advocacy groups, ... free registration, up to five nights, accommodation and a ...
... By Alan Mozes HealthDay Reporter , FRIDAY, March ... seek care at one of California,s hospital emergency departments leave ... of "leaves without being seen" varied widely across the state ... while the study authors said their results can,t be extrapolated ...
... inputs from humans that go beyond the traditional keyboard and ... tries to make using computers easier," says the Binghamton University ... intelligent way to use the computer? It should feel like ... people use computers the way everyone else does." Yin,s ...
... need more support before and after their child is born, ... happy to attend childbirth classes for their partner,s sake, some ... not have a ready outlet for their own fears and ... University of Gothenburg thesis by midwife Asa Premberg said they ...
... March 4 (HealthDay News) -- A free handbook to help ... is being offered by the American College of Emergency Physicians ... line of defense against underage drinking, but it can be ... guide parents through these conversations with their kids," said ...
Cached Medicine News:Health News:IASLC to help advocacy organizations attend 14th World Conference on Lung Cancer in Amsterdam 2Health News:1 in 5 Patients at California ERs Leaves Without Being Seen 2Health News:1 in 5 Patients at California ERs Leaves Without Being Seen 3Health News:Researchers use human cues to improve computer user-friendliness 2Health News:Researchers use human cues to improve computer user-friendliness 3Health News:Study Finds Men Need More Support Before, After Child Birth 2Health News:Ready to Talk to Your Teen About Alcohol? 2
(Date:12/17/2014)... -- , The new Dompé ... information concerning the biopharmaceutical Group,s national and international clinical research ... the recently launched institutional website that is receiving accolades from ... a new chapter in the fascinating story of Drug Discovery ... panoramic hub on the world of clinical research, ranging from ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, 2014 /PRNewswire/ ... Integrated Clinical Trial Services, LLC (ICTS), two firms ... trials announce that they have formed a joint ... i-CTMS will provide a broad range of patient ... medical device companies. i-CTMS will be ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... the "Electrocardiogram (ECG) Devices - Global Trends, Estimates ... http://photos.prnewswire.com/prnh/20130307/600769 Global ... million by 2016. The North America ... market share while Europe claims ...
Breaking Medicine Technology:Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4
... , BEVERLY HILLS, Calif., Dec. ... opiate detoxification procedure, offers one of the most advanced medical ... dependencies to Zolpidem, a prescription medication widely used for the short-term ... and Edluar. The Waismann Method of Rapid Ambien Detox ...
... , INDIANAPOLIS, Dec. 7 Roche Diagnostics announced today ... Pleasanton, California, as part of an initiative to make state-of-the-art ... laboratories on the west and east coasts. Roche has an ... planning to open an additional facility in New Jersey in ...
Cached Medicine Technology:Waismann Method Offers Safe and Alternative Treatment for Dependency to Ambien 2Waismann Method Offers Safe and Alternative Treatment for Dependency to Ambien 3Roche Diagnostics Opens State-of-the-Art Training Center in California 2
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
... Shuttle Relay Suture Passer allows braided suture ... repair procedures. It may be used ... material and in conjunction with anchors or ... Additionally, the Shuttle Relay can be ...
... Medical Record organizes communication and chart ... outside practitioners. It also manages orders, ... data that traditionally rely on many ... chart. With Microsoft Outlook integration, HealthMatics ...
Medicine Products: