Navigation Links
A change of heart: Penn researchers reprogram brain cells to become heart cells
Date:7/8/2011

PHILADELPHIA - For the past decade, researchers have tried to reprogram the identity of all kinds of cell types. Heart cells are one of the most sought-after cells in regenerative medicine because researchers anticipate that they may help to repair injured hearts by replacing lost tissue. Now, researchers at the Perelman School of Medicine at the University of Pennsylvania are the first to demonstrate the direct conversion of a non-heart cell type into a heart cell by RNA transfer. Working on the idea that the signature of a cell is defined by molecules called messenger RNAs (mRNAs), which contain the chemical blueprint for how to make a protein, the investigators changed two different cell types, an astrocyte (a star-shaped brain cell) and a fibroblast (a skin cell), into a heart cell, using mRNAs.

James Eberwine, PhD, the Elmer Holmes Bobst Professor of Pharmacology, Tae Kyung Kim, PhD, post-doctoral fellow, and colleagues report their findings online this week in the Proceedings of the National Academy of Sciences. This approach offers the possibility for cell-based therapy for cardiovascular diseases.

"What's new about this approach for heart-cell generation is that we directly converted one cell type to another using RNA, without an intermediate step," explains Eberwine. The scientists put an excess of heart cell mRNAs into either astrocytes or fibroblasts using lipid-mediated transfection, and the host cell does the rest. These RNA populations (through translation or by modulation of the expression of other RNAs) direct DNA in the host nucleus to change the cell's RNA populations to that of the destination cell type (heart cell, or tCardiomyocyte), which in turn changes the phenotype of the host cell into the destination cell.

The method the group used, called Transcriptome Induced Phenotype Remodeling, or TIPeR, is distinct from the induced pluripotent stem cell (iPS) approach used by many labs in that host cells d
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Climate change threatens endangered freshwater turtle
2. Many a mickle makes a muckle: How changes in animals size and shape arise
3. Lifestyle Changes Might Alter Breast Cancer Rates
4. After Diabetes Diagnosis, Concentrate on Dietary Changes, Study Says
5. What will climate change and sea level rise mean for barrier islands?
6. Gene change identifies brain cancer patients that respond better to treatment
7. Autism changes molecular structure of the brain, UCLA study finds
8. When Pregnant Mom Smokes, Babys DNA May Change
9. Gene expression changes in nasal cells may help identify lung cancer in earliest stages
10. Smokers undergo the same changes in gene expression as patients with COPD
11. Ecstasy associated with chronic change in brain function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A change of heart: Penn researchers reprogram brain cells to become heart cells
(Date:7/28/2014)... "I injured my shoulder and had to have ... Sunnyvale, Calif. "When I slept in one, I almost strangled ... and require too many straps. That is why I came ... Vest to improve the design of a standard sling. The ... properly. This helps to speed up the healing process. The ...
(Date:7/28/2014)... HealthDay Reporter FRIDAY, July 25, ... policy that bans blood donations from gay and bisexual men, according ... in the Journal of the American Medical Association . ... cannot donate blood in the United States -- a lifetime ban ... and Drug Administration adopted this policy at the dawn of the ...
(Date:7/28/2014)... MONDAY, July 28, 2014 (HealthDay News) -- Following a ... risk for chronic health issues, a new study indicates. ... who survived childhood cancer should be educated ... their health in the future. "These findings are ... for cancer as children have the opportunity to influence ...
(Date:7/28/2014)... "We experienced difficulty filling our pill ... two inventors from Jamestown, Calif. "We came up with ... we could pour medications in more easily." , They ... keep the lids open as the pill box is ... compartments have been filled. This eliminates hassles and frustrations, ...
(Date:7/28/2014)... Scientists in Japan have completed initial ... test for the asbestos cancer mesothelioma. Surviving Mesothelioma has ... Click here to read it now. , Researchers ... University Graduate School of Medicine say a new test ... above the old test. , “Particularly for the ...
Breaking Medicine News(10 mins):Health News:Lift U.S. Ban on Blood Donations by Gay Men, Experts Say 2Health News:Lift U.S. Ban on Blood Donations by Gay Men, Experts Say 3Health News:Healthy Habits May Help Childhood Cancer Survivors Avoid Chronic Ills 2Health News:Test Results Look Promising for New Mesothelioma Blood Test, According to Surviving Mesothelioma 2
... that only aims at malignant cells might fall short ... of normal cells which are present long before any ... is going to be, new research suggests. , Such ... the body, residing innocently there until certain cancer genes ...
... [New Jersey plastic surgeon] Dr. Paul M. Parker has been performing ... months. His patients have loved their sculpted tummies and their quick ... added two significant refinements to the procedure making the results and ... ...
... 5000 survey recognizes Alpharetta-based Company for outstanding growth, and success in ... ... 28, 2008 -- www.jacksonhealthcare.com [Jackson Healthcare] (JH) has been ... of the nation,s fastest growing and most entrepreneurial private companies. ...
... another Major Rise in Listeners. Affordable Health Insurance and Health ... ... City, MO (PRWEB) August 28, 2008 -- The Health Insurance Advocate ... 6th on 1260 AM and 104.1 FM KSGF. The weekly ...
... Volunteer to take part in Signature,Chefs Auction Galas, ... a kitchen near you: Chef Rahman "Rock" Harper will ... Chef Auctions open to the public,nationwide this fall., ... celebrity chef,spokesperson. In this role, Chef Rock, winner of ...
... for Efforts to Create Sensible Fire Safety ... ... have voted to maintain California,s tough fire,standards by striking down proposed fire ... of sensible,legislation to address fire safety regulations in the state. The bill ...
Cached Medicine News:Health News:Normal Cells May Predict Cancer Virulence 2Health News:Lipoabdominoplasty: A New Type of Tummy Tuck Gets Even Better 2Health News:Lipoabdominoplasty: A New Type of Tummy Tuck Gets Even Better 3Health News:Lipoabdominoplasty: A New Type of Tummy Tuck Gets Even Better 4Health News:Jackson Healthcare Ranked 48th of All Health Companies on Inc. Magazine's 2008 List of 5000 Fastest Growing Private Companies 2Health News:The Health Insurance Advocate Radio Show Expands to Springfield, Missouri, and Reaches a New All-Time Ratings High for Female Listenership 2Health News:The Health Insurance Advocate Radio Show Expands to Springfield, Missouri, and Reaches a New All-Time Ratings High for Female Listenership 3Health News:Chef Rock to Rock Signature Chefs Auctions(R) Nationwide 2Health News:California Senate Rejects Proposed Effort to Weaken Fire Safety Standards 2
(Date:7/28/2014)... 28, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ... 2014 Financial Results and Highlights Conference CallWhen:Monday, August 4 ... How:Live on the Internet. Simply log onto our ... during the live event, a replay of the webcast ... www.isispharm.com . ABOUT ISIS PHARMACEUTICALS, INC. Isis ...
(Date:7/28/2014)... , July 28, 2014 ... £2.5 million to help it meet the global ... healthcare, pharmaceuticals and logistics. Albion joins Shackleton Ventures. ... Over the past 18 months OmPrompt ... platform, its management team and its operations. The ...
(Date:7/25/2014)... July 25, 2014  Depomed, Inc. (NASDAQ: ... quarter fiscal year 2014 financial results after the market ... a conference call beginning at 4:30 pm EDT, 1:30 pm PDT ... the call by dialing 877-317-6789 ( United States ... also be available via a live webcast on the ...
Breaking Medicine Technology:Webcast Alert: Isis Pharmaceuticals' Second Quarter 2014 Financial Results Conference Call 2OmPrompt Funded for Customer Automation Management Market Expansion 2Depomed To Report Second Quarter Fiscal Year 2014 Financial Results On Wednesday, August 6, 2014 2
... Feb. 28, 2012   New Mexico Software, Inc. , d/b/a ... NMXC ), a developer of medical IT solutions and ... community, announced today that the company,s long standing suit brought ... judgment in favor of New Mexico Software. The ...
... 2012   Alexander Orthopaedic Associates (AOA) in Largo, FL, ... their practice with White Plume Technologies between Exscribe ... (ADSC) practice management system (PM system). EMRs ... the billing process unfilled. White Plume Technologies bridges ...
Cached Medicine Technology:New Mexico Software Prevails in Lawsuit 2Alexander Orthopaedic Associates Chooses White Plume Technologies to Fill the EMR Gap 2
Each handle is designed to fit a specific trephine size....
Each handle is designed to fit a specific trephine size....
Each handle is designed to fit a specific trephine size....
Each handle is designed to fit a specific trephine size....
Medicine Products: