Navigation Links
A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
Date:5/3/2010

Lung researchers at Johns Hopkins have identified a possible protein trigger responsible for sarcoidosis, a potentially fatal inflammatory disease marked by tiny clumps of inflammatory cells that each year leave deep, grainy scars on the lungs, lymph nodes, skin and almost all major organs in hundreds of thousands of Americans.

The disorder, whose cause has been a persistent mystery for nearly a century, strikes mostly young adults and disproportionately affects African Americans.

The link between sarcoidosis and overproduction of the suspected protein trigger, called serum amyloid A, was revealed after a six-year investigation encompassing more than two dozen laboratory experiments, including some on diseased lung tissue samples from 86 patients in the Baltimore area.

"The increase in production of serum amyloid A explains for the first time how inflammation can persist in the lungs without being triggered by an active infection," says study senior investigator and pulmonologist David Moller, M.D., a professor at the Johns Hopkins University School of Medicine. Moller is also director of the sarcoidosis clinic at The Johns Hopkins Hospital.

Study lead investigator Edward Chen, M.D., says the new findings also clear the path for developing drug treatments or vaccines that can block serum amyloid A from binding to cell receptors and kicking off inflammation.

In the short term, however, Moller says his team has plans to use the study results to create diagnostic tests that could better predict which people with the disease are likely to heal on their own or are more likely to suffer persistent inflammation, which can lead to scarring, difficulty breathing, and heart failure that can only be fixed by lung transplantation.

In a report published in February in the American Journal of Respiratory and Critical Care Medicine, the Johns Hopkins scientists described their research on what was behind the mic
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. HIV researchers solve key puzzle after 20 years of trying
2. Three New Behavioral Health Companies Sign On With MyOutcomes
3. Transplant drug 2-year study outcomes show superior kidney function
4. Study shows liver transplant center impacts patient outcomes
5. Researchers make advances in understanding causes, treatments and outcomes of liver disease
6. New studies examine adverse outcomes associated with obesity and more applicable measures of obesity
7. Hair Loss Doctor Overcomes Odds To Produce First Ever Combination Topical Hair Growth Formula
8. Savvy Mom TV™ Welcomes Dr. Cynthia R. Green, Ph.D. as their Brain Health Expert
9. Typical Male Behavior Comes From Estrogen, Too
10. ATS systematic review: Critical care outcomes tied to insurance status
11. Complete revascularization improves outcomes for CAD patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... (PRWEB) July 29, 2014 truBrain has ... fix provided by energy drinks. Think Drinks , ... nutrition that creates optimal conditions for memory, complex reasoning ... truBrain hopes to raise $50,000 over the course of ... stable mental boost and have compounding effects over time ...
(Date:7/29/2014)... 2014 The report “Filling Equipment ... (Rotary, Volumetric, Aseptic, Net Weight), Process (Manual, Semi-Automatic, ... Global Trend & Forecast to 2019”, defines the ... beverage, pharmaceutical, and cosmetic segments with analyses and ... these segments, in terms of value. It also ...
(Date:7/29/2014)... 2014 CD-adapco™, the largest privately ... software, today announced its renewed membership with ... public-private partnership focused exclusively on the unique needs ... progress in the first year by bringing together ... Computational Modeling and Simulation (CM&S). This momentum will ...
(Date:7/29/2014)... Outsourced coding and Clinical Documentation Improvement ... of hospitals contracting for external CDI services help ... the recently published Black Book™ survey of 650 ... reports “Top Ranked Clinical Documentation Improvement Vendors”. , ... audit, review and programming. By Q3 2015, 71 ...
(Date:7/29/2014)... Botanica Day Spa continues their celebration of summer with the ... waxes to clients in the Tampa Bay area. In ... a number of new client specials including great deals on ... a free mini facial with their first Brazilian wax at ... downtown Clearwater, FL celebrates its twentieth year in business in ...
Breaking Medicine News(10 mins):Health News:Focus- and Productivity-Enhancing Beverage Launches Crowdfunding Campaign on Indiegogo 2Health News:Filling Equipment Market worth $8 Billion by 2019 - Report by MarketsandMarkets 2Health News:Filling Equipment Market worth $8 Billion by 2019 - Report by MarketsandMarkets 3Health News:Filling Equipment Market worth $8 Billion by 2019 - Report by MarketsandMarkets 4Health News:CD-adapco Helps Advance the Use of Simulation in Medical Device Industry 2Health News:Clinical Documentation Improvement Heats Up as Half of US Hospitals Make 2015 Preparations for ICD-10, the Rest to Rely on Outsourcers, Black Book Survey Reveals 2Health News:Clinical Documentation Improvement Heats Up as Half of US Hospitals Make 2015 Preparations for ICD-10, the Rest to Rely on Outsourcers, Black Book Survey Reveals 3Health News:Award-Winning Botanica Day Spa Celebrates 12,000 Brazilian Bikini Waxes 2Health News:Award-Winning Botanica Day Spa Celebrates 12,000 Brazilian Bikini Waxes 3
... magazines or advertising for,treatment information, NEW YORK, ... ( http://www.injectablesafety.org ) and the health and,beauty community ... joint survey reporting that 40% of consumers are ... of consumers feel FDA approval,of an injectable is ...
... for Dedication to Improving, Animal Health and Well-Being; Co-sponsored ... FANCY, CAT FANCY and Veterinary ... you think your veterinarian is the,best in America, nominate ... Vet,for a Healthy Pet(SM) Contest. The national short-essay contest ...
... Mercury Computer,Systems, Inc. (NASDAQ: MRCY ), ... complex image, sensor, and signal,processing applications, announced that ... on Thursday, May 29, 2008 at the Cowen ... at the New York Palace Hotel, in New ...
... a health care problem all over the world, with 130 ... and has variable results according to the genotype of the ... virus clearance at the end of the treatment called End ... ETR have a relapse within the next six months. Thus, ...
... advance underdeveloped approaches to designing a preventive HIV vaccine, ... part of the National Institutes of Health, is launching ... cells, immune cells that can produce antibodies with the ... will strengthen and expand the scientific foundation of HIV ...
... use yields practical guides for,physicians, consumers, employers, health ... The non-profit eHealth,Initiative (eHI) and the Center ... of a widely anticipated report detailing the,impact of ... plans and policy makers nationwide. Based on,research as ...
Cached Medicine News:Health News:New Survey Suggests That Consumers Are Naive to the Risk of Botox Parties and the Importance of FDA Approval for Cosmetic Injectables 2Health News:New Survey Suggests That Consumers Are Naive to the Risk of Botox Parties and the Importance of FDA Approval for Cosmetic Injectables 3Health News:New Survey Suggests That Consumers Are Naive to the Risk of Botox Parties and the Importance of FDA Approval for Cosmetic Injectables 4Health News:Morris Animal Foundation Searches for America's Best Vet With 'Thank Your Vet for a Healthy Pet(SM)' Contest 2Health News:Morris Animal Foundation Searches for America's Best Vet With 'Thank Your Vet for a Healthy Pet(SM)' Contest 3Health News:Mercury Computer Systems to Present at the Cowen and Company 20/20 Technology-Media-Telecom Conference on May 29, 2008 2Health News:NIAID to advance B-cell approach to HIV vaccines 2Health News:NIAID to advance B-cell approach to HIV vaccines 3Health News:eHealth Initiative and the Center for Improving Medication Management to Present Report Detailing Both Impact of E-Prescriptions on U.S. Health Care System and Guidelines for Achieving Optimal Results 2Health News:eHealth Initiative and the Center for Improving Medication Management to Present Report Detailing Both Impact of E-Prescriptions on U.S. Health Care System and Guidelines for Achieving Optimal Results 3
(Date:7/29/2014)... COLORADO SPRINGS, Colo. , July 29, 2014 /PRNewswire-USNewswire/ ... remote-controlled catheter (MARC) which could allow physicians to see ... stroke may hold promise, according to study authors who ... Surgery (SNIS) 11 th Annual Meeting in ... findings stand to advance the field of neurointervention, a ...
(Date:7/29/2014)... and NEW YORK , ... of the executive management team of Caremark Rx, ... Media ( www.pbm365.com ).  PBM365 is the leading independent ... reporting, insight, analysis and opinion on the pharmacy ... will provide insightful and timely coverage of, and context ...
(Date:7/29/2014)... , July 29, 2014  Roche (SIX: RO, ... Association for Clinical Chemistry (AACC) 2014 Clinical Lab Expo ... on the unique ways Roche is partnering with customers ... "Our customers tell us every day that they,re looking ... they deliver in their labs and offices," said ...
Breaking Medicine Technology:New Technology May Improve Visualization Of The Brain During Stroke Treatment 2New Technology May Improve Visualization Of The Brain During Stroke Treatment 3Drew Crawford Announces Launch of PBM365 Media 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 3Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 4
... June 15, 2011 The American Academy of ... 2011 AAFP Foundation Pfizer Immunization Award winners. These ... achieved increased immunization rates in their communities through ... the AAFP,s National Conference were presented to 16 ...
... June 15, 2011 To address surgeons, need for ... in open surgery, Ethicon Endo-Surgery, Inc. (EES) today announces ... advanced bipolar technology.  The new technology is designed with ... sealing vessels consistently along the length of the 40mm ...
Cached Medicine Technology:Family Medicine Residency Programs Recognized for Improving Childhood and Adult Immunizations Rates in Underserved Communities 2Family Medicine Residency Programs Recognized for Improving Childhood and Adult Immunizations Rates in Underserved Communities 3Ethicon Endo-Surgery Launches ENSEAL® G2 Super Jaw 2
Can download data from your A&D balance directly to your PC saving time and reducing the chances of manually recording the wrong weighing data; 60 month warranty; automatic adjustable environment set...
... The ABI Prism 7000 Sequence Detection ... system that detects and quantitates nulceic ... detection of accumulated PCR product is ... fluorescence detection, and application-specific software in ...
... 3100 system offers continuous, unattended operation ... separation and detection, and data analysis. ... and importing sample information, the operator ... Run command. The instrument requires no ...
Coated-Tube (CT) RIA kit for the determination of autoantibodies to the TSH receptor (TSHR) in serum...
Medicine Products: