Navigation Links
A blueprint for 'affective' aggression
Date:9/4/2012

A North Carolina State University researcher has created a roadmap to areas of the brain associated with affective aggression in mice. This roadmap may be the first step toward finding therapies for humans suffering from affective aggression disorders that lead to impulsive violent acts.

Affective aggression differs from defensive aggression or premeditated aggression used by predators, in that the role of affective aggression isn't clear and could be considered maladaptive. NC State neurobiologist Dr. Troy Ghashghaei was interested in finding the areas of the brain engaged with this type of aggressive behavior. Using mice that had been specially bred for affective aggression by his research associate Dr. Derrick L Nehrenberg, Ghashghaei and former undergraduate student Atif Sheikh were able to locate the regions in the mouse brain that switched on and those that were off when the mice displayed affective aggression.

"The brain works by using clusters of neurons that cross communicate at extremely rapid rates, much like a computer," Ghashghaei explains. "One region will process a stimulus, and then that region sends messages to other clusters within the brain, like circuits within a computer. We looked at how the switches flipped in the brains of aggressive mice, and compared that with the brains of completely nonaggressive mice in the same setting, to see how the two processed the situation differently."

They found that affectively aggressive mice demonstrated a large difference in the way their "executive centers" operated when the mice encountered another mouse. "Sensory inputs come in and are sent to the executive center, the part of the brain that decides how to respond to the input," Ghashghaei says. "In the meantime, the information about the response you made gets processed back with either a pleasant or unpleasant association."

According to Ghashghaei, the affectively aggressive mice could react violently because their brains are hardwiredto respond to certain situations aggressively without assessing whether their response to the situation is appropriate or without regard to the behavior's consequences. In addition, affectively aggressive mice may be forming pleasant associations with their violent displays, which would reinforce their aggressive tendencies.

"We cannot say which of the two possibilities underlie the persistent aggressive displays by our mice," Ghashghaei says, "but we can see that the patterns of neuronal activity are very different in the executive centers of these mice. Additionally, there are differences in the neuronal clusters involved with creating pleasant or unpleasant associations to the stimulus or their response. That gives us a few starting spots to begin identifying the mechanisms that underlie these profound behavioral differences."

The regions of the brain that were involved in affective aggression in the mice are similar across all mammalian species. Ghashghaei hopes that his findings in mice will be useful to researchers studying violent behavior in humans, as well as aggression in other animals.

"With the brain, just knowing where to start looking is huge," Ghashghaei says. "Once you have a few targets, you can tease out the possibilities and get to the heart of the problem. We are confident that manipulation of some of the identified targets in our study will disrupt displays of affective aggression in our mouse model."

The researchers' findings appear online in Brain Structure and Function.


'/>"/>

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

Related medicine news :

1. Mayo Clinic, youth mental health experts, publish new guidelines to treat childhood aggression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... and print media enterprise focused entirely on patients with cancer, today announced that ... was chosen as the 2016 CURE® Extraordinary Healer® for Oncology Nursing , ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... outsourced billing and coding services, and Deyta Analytics, recently announced the recipients of ... highest level of quality as measured from the caregiver’s point of view. The ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Pro3rd Grunge ... Utilize Pixel Film Studios’ lower thirds to introduce people, characters, and locations without having ... include boxes, lines, accents, textures and many more design components. Simply select a preset ...
(Date:4/28/2016)... ... April 29, 2016 , ... Monthly subscription boxes are all the rage, and ... recently reviewed the ZEN BOX , the aromatherapy subscription box. , ZEN BOX delivers ... lavender or frankincense) and one Zen Blend (like immune boost, sublime sleep or de-stress ...
(Date:4/28/2016)... ... 28, 2016 , ... La Sirena Foods provides premium canned seafood, specifically, Tuna, ... looking to grow their market share in the USA. , "We are happy to ... Sirena Foods and indirectly with Otis McAllister , a leading global food ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 2016   , ... Recurring Consumable Sales  Clinical sales grow 16% ... (Euronext: MKEA, OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary ... the first quarter ended March 31, 2016 and provided ... its commercial strategy. First Quarter 2016 Revenue ...
(Date:4/27/2016)... NORWALK, Conn. , April 27, 2016 /PRNewswire/ ... availability of its digital health technology platform, which ... services and programs into scalable digital products, Zillion ... mobile engagement and empower consumers to take control ... features face-to-face live video conferencing – including one-to-one, ...
(Date:4/27/2016)... April 27, 2016 Shire plc (LSE: ... Poulton , Chief Financial Officer, will present at the Deutsche ... MA on Wednesday, May 04, 2016, 10:00 am ... be available on the Presentations and Webcasts section of Shire,s ... the webcast will be available on this same website for ...
Breaking Medicine Technology: