Navigation Links
A blood test for Alzheimer's disease?
Date:1/6/2011

Using a new technology that relies on thousands of synthetic molecules to fish for disease-specific antibodies, researchers have developed a potential method for detecting Alzheimer's disease with a simple blood test. The same methodology might lead to blood tests for many important diseases, according to the report in the January 7th issue of the journal Cell, a Cell Press publication.

"If this works in Alzheimer's disease, it suggests it is a pretty general platform that may work for a lot of different diseases," said Thomas Kodadek of The Scripps Research Institute. "Now we need to put it in the hands of disease experts to tackle diseases where early diagnosis is key."

The new method relies on the notion that many diseases lead to the production of modified proteins. At some point, the adaptive immune system might begin to recognize those proteins as foreign and mount a response. If tests could be developed to recognize those disease-specific proteins or the antibodies that recognize them, it could be the basis for early diagnosis. But in most cases, researchers have had little luck identifying those abnormal proteins.

Kodadek's team decided to take a different tack. They used a large library of randomly selected, unnatural molecules known as "peptoids" to screen for antibodies found in the bloodstream of animals or patients with specific diseases and not in healthy controls.

"The peptoids are really just random shapes," Kodadek explained. The method is really practical, he says, because it allows for the assembly of enormous chemical libraries with little effort. It also offers a way to "step outside of the usual biological or chemical space" in search of molecules that might just fill the pockets of antibodies playing unknown roles in disease.

As a proof of concept, the researchers started with mice with experimental autoimmune encephalitis, a condition that resembles multiple sclerosis in humans. It w
'/>"/>

Contact: Elisabeth Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Inflammatory Bowel Ups Risk for Blood Clots
2. Bowel disease link to blood clots
3. Local Blood Supply Impacted by Wednesdays Severe Snow Storm
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
6. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
7. Bilberry Seems to Act Against Blood Sugar
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
10. NHLBI, CDC launch surveillance and research program for inherited blood diseases
11. IOM report declares high blood pressure a neglected disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... 18, 2014) Benaroya Research Institute at Virginia Mason ... a particular molecule in metastatic breast cancer reduces both ... lung metastases. BRI scientists have found in models of ... by 60 - 80 percent and can keep the ... $1.8 million five-year grant comes from the National Cancer ...
(Date:4/17/2014)... presence of chronic inflammation in benign prostate tissue ... and this association was found even in those ... a study published in Cancer Epidemiology, Biomarkers ... Association for Cancer Research. , An analysis of ... the placebo arm of the Prostate Cancer Prevention ...
(Date:4/17/2014)... study published today in PLOS Pathogens , children ... is common can mount an immune response to infection ... repeated bouts of high fever and illness and partially ... The findings may help researchers develop future interventions that ... parasite. , Each year, approximately 200 million cases of ...
(Date:4/17/2014)... Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, was ... April issue of Nature Reviews Microbiology , ... Dr. McCullers, a world-renowned infectious disease specialist, and ... University of Tennessee Health Science Center, analyzed the ... 1957 and 1968 pandemics, as well as more ...
(Date:4/17/2014)... NY (April 16, 2014) The cause of neuronal ... new study proposes that neurons may be mistaken for ... system, similar to the way autoimmune diseases like type ... body,s cells. The study was published April 16, 2014, ... new, and likely controversial, idea in Parkinson,s disease; but ...
Breaking Medicine News(10 mins):Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Is Parkinson's an autoimmune disease? 2
... software that helps you work smarter by communicating visually, is becoming ... document and standardize processes across hospital departments in order to meet ... ... 26, 2009 -- SmartDraw.com, maker of SmartDraw, the software that helps ...
... that good lifestyle choices help prevent diabetes type 2CHICAGO, March ... offense is a good defense - in football and in ... about diabetes in his own family. "Seeing my mother lose ... bit. I think about all the things Mom could have ...
... G. Komen for the Cure(R) Advocacy Alliance applauds the ... Bailey Hutchison (R-TX) to reignite the war on cancer ... ALERT ( A ccess to L ife-saving ... reatment) Act. (Logo: http://www.newscom.com/cgi-bin/prnh/20070122/NYM084LOGO )"It,s been ...
... March 26 /PRNewswire-HISPANIC PR WIRE/ -- Pfizer,Helpful Answers ... years ago in partnership with the Dallas Concilio ... San Antonio and Corpus Christi gain,greater access to ... train five community health workers - promotores - ...
... in inpatient practice management, announces growth in leadership in ... (IM) recently appointed two additional members to serve on ... in conjunction with a new CEO and increased staff.Mark ... over 20 years of entrepreneurial, financial and operational leadership ...
... Elizabeth Espinoza and Mark Williams Named National Epilepsy Spokespersons ... Mark Williams, siblings from Hutto, TX will travel to ... 2009 to meet with congressional leaders and gain their ... toward a cure for epilepsy as part of the ...
Cached Medicine News:Health News:SmartDraw Helps Hospitals Document and Standardize Processes to Achieve Greater Compliance With Regulatory Agencies 2Health News:SmartDraw Helps Hospitals Document and Standardize Processes to Achieve Greater Compliance With Regulatory Agencies 3Health News:Blue Cross and Blue Shield of Illinois Teams with Chicago Bears Coach Lovie Smith in Diabetes Awareness Drive 2Health News:Blue Cross and Blue Shield of Illinois Teams with Chicago Bears Coach Lovie Smith in Diabetes Awareness Drive 3Health News:Blue Cross and Blue Shield of Illinois Teams with Chicago Bears Coach Lovie Smith in Diabetes Awareness Drive 4Health News:Susan G. Komen for the Cure(R) Advocacy Alliance Applauds Senators Kennedy, Hutchison for Bipartisan Cancer Alert Act 2Health News:March 22-28 is Cover the Uninsured Week 2Health News:March 22-28 is Cover the Uninsured Week 3Health News:Ingenious Med Expands Leadership and Adds Members to Board of Directors 2Health News:Ingenious Med Expands Leadership and Adds Members to Board of Directors 3Health News:Texas Siblings Share Epilepsy Message on Capitol Hill 2
(Date:1/15/2014)... Texas , Jan. 15, 2014  Novation, the leading ... awarded several new IT value-added reseller (VAR) national contracts ... IT goods and services at lower costs. These include ... services such as initiative assistance and ongoing IT consulting ...
(Date:1/15/2014)... OAKS, Calif. , Jan. 15, 2014 ... Amgen (NASDAQ: AMGN ) announced today ... jointly discover and validate new therapeutic targets and ... a chronic disorder that affects millions worldwide. The ...
(Date:1/15/2014)... 15, 2014  Humberto C. Antunes,  Galderma  worldwide CEO, will ... Journal of Drugs in Dermatology (JDD) at ... The event is January 17-20, 2014, at the Omni Orlando Resort ... The ODAC is a distinguished event that ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4
... anti-mail-service pharmacy legislation, New York Governor Andrew Cuomo announced ... to amend NY AB 5502-B, which prevents employers from ... cost mail-service pharmacy option. "Employers, taxpayers, ... to improve this costly, anti-consumer bill," said Pharmaceutical ...
... RIDGE, Colo., Dec 13, 2011 MedEfficiency, Inc., ... the development, manufacturing, and marketing of medical devices ... today announced that it has been awarded a ... contract, MedEfficiency will be listed as a government-approved ...
Cached Medicine Technology:PCMA: Governor Cuomo's Call to Amend Anti-Mail-Service Pharmacy Law Protects Employers and Consumers 2PCMA: Governor Cuomo's Call to Amend Anti-Mail-Service Pharmacy Law Protects Employers and Consumers 3MedEfficiency Awarded VA Contract for Its Total Contact Casting Products 2
TEW serrated micro-retractor blade set....
Micro-retractor arm 12"....
The Budde Halo Retractor Side Rail Support is designed for the adaptation and attachment of the Budde Halo Brain Retractor System to the operating room table when a conventional skull clamp is not us...
Epstein Curettes 3.0 mm, length 8" (203 mm)....
Medicine Products: