Navigation Links
A better way to test new treatments? Approach could help patients and give useful results
Date:7/2/2012

ters around how patients are randomly assigned to one of the two or more groups in a study. In a non-adaptive trial, everyone who volunteers from the first patient to the last gets assigned with what amounts to a coin toss, and the groups end up being of similar size.

But in an adaptive trial, the trial's statistical algorithm constantly monitors the results from the first volunteers, and looks for any sign that one treatment is better than another. It doesn't tell the patients or the study doctors what they're seeing, but they do start randomly assigning slightly more patients into the group that's getting the treatment that is starting to look better. In other words, the trial "learns" along the way.

"It's a way of assigning patients at slightly less than random chance, allowing us to do what might be in the best interest of each patient as the trial goes along," says Meurer, an assistant professor of emergency medicine and neurology at the U-M Medical School.

By the end of the trial, one of the groups of patients will therefore be larger, which means the statistical analysis of the results will be trickier and the results might be a little less definitive. But if the number of patients in the trial is large, and if the difference between treatments is sizable, the results will still have scientific validity, Meurer says.

A clinical trial of post-stroke blood sugar treatment is one example of this kind of approach. It's being coordinated by the Neurological Emergencies Treatment Trial network based at U-M, and conducted at dozens of centers including, in coming months, U-M's own emergency department and inpatient stroke unit.

The study, called SHINE, uses an adaptive method of assigning stroke survivors to a target blood sugar level in the first day after their stroke with the goal of finding out how much impact blood sugar control has on how well the patients do overall. The study was designed by researchers at th
'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Better Health Osteopathic & Integrative Medicine Centre Provides Health Education and Care
2. Building a better Rift Valley fever vaccine
3. Better Health Screening Urged for Female College Athletes
4. Preventing or better managing diabetes may prevent cognitive decline, according to UCSF study
5. A better way to help high-risk pregnant smokers
6. 'Music Makes It Better' Campaign Launches with Justin Bieber, Victoria Justice, and The Band Perry
7. Elderly prisoners need better medical care, according to report
8. Exercise Controls Weight in White Girls Better Than in Black Girls: Study
9. ASCO: Younger colon cancer patients have worse prognosis at diagnosis, yet better survival
10. Half of Americans with individual health plans could gain better coverage under the ACA
11. Phone contact with nurses linked with better outcomes for women with gestational diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... Hastings and Hastings, a Phoenix personal injury ... the greater Phoenix area and across Arizona reports record ... catastrophic automobile accidents. Statistics have indicated a steady increase ... As such, Hastings and Hastings has seen a steady ... who have been injured through no fault of their ...
(Date:10/19/2014)... UNITED NATIONS, New York (PRWEB) October 19, 2014 ... the United Nations Population Fund, welcomes news of a ... release of the more than 200 girls who were ... Girls. "These girls have languished in captivity long enough, ... their families, schools and communities," stated Dr. Osotimehin. , ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest hosting ... HostMonster are the best VPS hosting suppliers in ... the method of partitioning a physical server computer ... appearance and capabilities of running on someone’s own ... close attention to VPS products and related suppliers. ...
(Date:10/19/2014)... NC (PRWEB) October 19, 2014 ... building program has just been released to the ... the online body building and fitness community. The ... attention of DietsAndFitnessGuides.com's Vin Delmonico prompting an investigative ... experience of hitting what is commonly known as ...
(Date:10/19/2014)... causes inflammation in the spinal joints and was ... Egyptian royal families. Now a new study published ... of the American College of Rheumatology (ACR), refutes ... called diffuse idiopathic skeletal hyperostosis (DISH) in royal ... Dynasties. , Ankylosing spondylitis is a member ...
Breaking Medicine News(10 mins):Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2Health News:Mummy remains refute antiquity of ankylosing spondylitis 2
... may be especially prone to depression this time of year, ... some older people, the holidays can generate feelings of sadness ... health problems, experts note. , To help seniors ward ... the following tips: , Socialize. Ask family and friends ...
... Universal Health,Services, Inc. (NYSE: UHS ) announced ... 5 million share repurchase program to supplement,the 1 ... the stock repurchase program, the Company, from time ... the open market or in negotiated,private transactions., ...
... -- A test for four blood proteins may provide a ... radiographs or computerized tomography (CT) scans, according to a new ... CT scans have a very high false positive rate when ... a radiologist at Duke and lead investigator on the study. ...
... FORT ATKINSON, Wis., Dec. 7 EMS Magazine, the ... the winners of the EMS EXPO 2007 Top Picks, ... the year. The winners were chosen,by industry experts and ... The awards were presented at the Texas EMS State ...
... Hologic, Inc. (Nasdaq:,HOLX) today announced that Patrick Sullivan, ... participate in the RBC Capital Markets,2007 Healthcare Conference ... Square Hotel in New York., Interested parties ... webcast of,Hologic,s investor presentation on Wednesday, December 12, ...
... be passed on to nursing infants, rat study shows , , ... mechanism by which a chemical known as perchlorate can collect ... newborns. , Used since the 1940s to manufacture explosives and ... water and food supply, experts say. , And high concentrations ...
Cached Medicine News:Health News:How to Spot, and Beat, the Holiday Blues 2Health News:Study points to possibility of blood test to detect lung cancer 2Health News:EMS Magazine Announces Top Product Innovations for 2007 2Health News:EMS Magazine Announces Top Product Innovations for 2007 3Health News:Environmental Toxin Collects in Breast Milk 2Health News:Environmental Toxin Collects in Breast Milk 3
(Date:10/17/2014)... 17, 2014 ... announced the addition of the  "China Interventional ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... China impacted by ... consumption concept, dietary habit, way of working ...
(Date:10/17/2014)... , October 17, 2014 ... Pharmaceuticals Inc. (NASDAQ: ARNA ), NPS Pharmaceuticals ... XOMA ), Momenta Pharmaceuticals Inc. (NASDAQ: ... CPRX). Free research on these five companies can be ... markets on Thursday, October 16, 2014, ended on a ...
(Date:10/17/2014)... , Oct. 17, 2014  Ameritox SM , the ... appointment of Thomas Smith , M.D., as Chief ... field-based team offering scientific resources for healthcare providers, patients ... held leadership positions at a variety of healthcare companies ... both the pain and behavioral health sides of Ameritox,s ...
Breaking Medicine Technology:China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3Biotech Equities Technical Briefing - Arena Pharma, NPS Pharma, XOMA, Momenta Pharma, and Catalyst Pharma Partners 2Biotech Equities Technical Briefing - Arena Pharma, NPS Pharma, XOMA, Momenta Pharma, and Catalyst Pharma Partners 3Biotech Equities Technical Briefing - Arena Pharma, NPS Pharma, XOMA, Momenta Pharma, and Catalyst Pharma Partners 4Biotech Equities Technical Briefing - Arena Pharma, NPS Pharma, XOMA, Momenta Pharma, and Catalyst Pharma Partners 5Ameritox Appoints New Chief Medical Officer 2
... 5 Lincare Holdings Inc. (Nasdaq: LNCR ) ... the employment agreements with its Chief Executive Officer, John ... S. Schabel and its Chief Financial Officer, Paul G. ... each executive officer,s employment with the company for three ...
... CHENGDU, China, Oct. 5 /PRNewswire-Asia-FirstCall/ -- Tianyin,Pharmaceutical ... manufacturer and,supplier of modernized traditional Chinese medicine ("TCM") and ... to be paid,to its common stock shareholders. The dividend ... of October 30, 2009, with the actual distribution,occurring on ...
Cached Medicine Technology:Lincare Holdings Inc. Extends Terms of Employment Agreements with Executive Officers 2Tianyin Pharmaceutical, Co. Announces Cash Dividend to Common Shareholders - Record Date October 30, 2009 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: