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A*STAR scientists discover 'switch' critical to wound healing
Date:3/8/2013

ained high levels of miR-198 but no FSTL1 protein. They demonstrated that these high levels of miR-198 prevent skin cell migration by suppressing several genes, such as PLAU, LAMC2 and DIAPH1 , which are needed for different aspects of the wound healing process. However upon injury, miR-198 is switched off in the wound by a signal from transforming growth factor β1 (TGF-β1). This allows FSTL1 to now be made instead, and the skin migration genes to be unblocked, promoting migration of skin cells into the wound area to drive skin wound healing.

10. The scientists further examined skin samples of chronic non-healing ulcer wounds from patients with diabetes mellitus. They observed that, unlike healthy skin that had been injured, there remained high levels of miR-198 (inhibiting skin cell migration and wound healing) and an absence of FSTL1 protein (promoting skin cell migration upon wounding), indicating that this "switch" is defective in chronic wounds. (Annex A)


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Contact: Ong Siok Ming (Ms)
ong_siok_ming@a-star.edu.sg
656-826-6254
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert  

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A*STAR scientists discover 'switch' critical to wound healing
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