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A*STAR scientists discover 'switch' critical to wound healing
Date:3/8/2013

etes. Chronic wounds also tend to affect the elderly and disabled patients, especially those confined to a wheelchair or bed-bound. Unfortunately, chronic wounds are currently poorly understood and insufficiently treated.

6. Dr. Prabha Sampath , principal investigator at IMB and lead author of the paper, said, "Our research provides a comprehensive understanding of the mechanism of the wound healing process. Moving forward, we hope to translate this research into improved patient outcomes. We can now build on this research, to see how we can modulate the defective switch in chronic wounds by targeting miR-198 and its interacting molecules, to develop new strategies for treating chronic wounds."

7. Professor Birgitte Lane, Executive Director of IMB, said, "This switch appears to be an entirely new regulatory component in wound healing, and probably a very important one. Poor wound healing is a major healthcare burden, and this discovery is particularly timely in the face of aging populations and the sharp global rise in diabetes. The finding gives us a platform from which to develop therapies that could significantly reduce chronic wounds and improve healthcare."

An FSTL1-miR-198 molecular 'see-saw' switch.

8. The information necessary to express microRNA-198 (miR-198) and follistatin-like 1 (FSTL1) protein are found in a single "message" produced by the cell. However, miR-198 and FSTL1 protein cannot be produced at the same time it can only be one or the other. These two molecules also have opposite roles: miR-198 (found in unwounded skin) inhibits skin cell migration and wound healing, whereas FSTL1 protein (expressed after injury) promotes skin cell migration and wound healing. A regulatory switch dictates their expression, and hence controls the "see-saw" between inactive resting skin cells and the cell migration necessary for wound healing.

9. Dr. Sampath and her team showed that healthy unwounded skin cont
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Contact: Ong Siok Ming (Ms)
ong_siok_ming@a-star.edu.sg
656-826-6254
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert  

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