Navigation Links
A*STAR scientists discover 'switch' critical to wound healing
Date:3/8/2013

etes. Chronic wounds also tend to affect the elderly and disabled patients, especially those confined to a wheelchair or bed-bound. Unfortunately, chronic wounds are currently poorly understood and insufficiently treated.

6. Dr. Prabha Sampath , principal investigator at IMB and lead author of the paper, said, "Our research provides a comprehensive understanding of the mechanism of the wound healing process. Moving forward, we hope to translate this research into improved patient outcomes. We can now build on this research, to see how we can modulate the defective switch in chronic wounds by targeting miR-198 and its interacting molecules, to develop new strategies for treating chronic wounds."

7. Professor Birgitte Lane, Executive Director of IMB, said, "This switch appears to be an entirely new regulatory component in wound healing, and probably a very important one. Poor wound healing is a major healthcare burden, and this discovery is particularly timely in the face of aging populations and the sharp global rise in diabetes. The finding gives us a platform from which to develop therapies that could significantly reduce chronic wounds and improve healthcare."

An FSTL1-miR-198 molecular 'see-saw' switch.

8. The information necessary to express microRNA-198 (miR-198) and follistatin-like 1 (FSTL1) protein are found in a single "message" produced by the cell. However, miR-198 and FSTL1 protein cannot be produced at the same time it can only be one or the other. These two molecules also have opposite roles: miR-198 (found in unwounded skin) inhibits skin cell migration and wound healing, whereas FSTL1 protein (expressed after injury) promotes skin cell migration and wound healing. A regulatory switch dictates their expression, and hence controls the "see-saw" between inactive resting skin cells and the cell migration necessary for wound healing.

9. Dr. Sampath and her team showed that healthy unwounded skin cont
'/>"/>

Contact: Ong Siok Ming (Ms)
ong_siok_ming@a-star.edu.sg
656-826-6254
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
2. Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
3. A*STAR scientists identify potential drug target for inflammatory diseases including cancers
4. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
5. Scientists solving the mystery of human consciousness
6. Scientists uncover multiple faces of deadly breast cancer
7. Scientists identify major source of cells defense against oxidative stress
8. Scientists tailor cell surface targeting system to hit organelle ZIP codes
9. Scientists rewrite rulebook on breast cancer in landmark global study
10. Warwick scientists uncover how checkpoint proteins bind chromosomes
11. NIH scientists link quickly spreading gene to Asian MRSA epidemic
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A*STAR scientists discover 'switch' critical to wound healing
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... Analytical, based in Ames, IA will reveal the latest results ... system. This instrument rapidly identifies microorganisms in less ... The generated fingerprint when compared to a database of ... strain typing and tracking.Because of its ease of use and ...
... 2009, the United States District Court for the Southern ... previously disclosed antitrust lawsuit filed by Pioneer Valley Casket ... casket retailers against Batesville Casket Company, Inc., a wholly ... )The Pioneer Valley plaintiffs agreed to dismiss their complaint ...
... Inc. (NYSE: DVA ) announced that the United ... has informed the company that it has completed its investigation ... was first issued a formal subpoena in October 2004 and ... against the company, no fines were assessed and no mandatory ...
... A new survey from Noblis Health Innovation, a ... context of the current economic crisis, nearly a third of hospitals ... Conducted in April 2009, the affiliation study is the first in ... Noblis Insights Panel , a collection of more than 150 leading ...
... make that dream so real, goes a popular song. Now ... to perform an essential form of DNA repair. , Prof. ... been studying DNA repair for some two decades: ,Considering that ... a day by radiation, pollutants and harmful chemicals produced within ...
... Cancer Screenings And Education about Skin Cancer PreventionSKILLMAN, N.J., ... Johnson Consumer Companies, Inc., announces its second year of ... Skin" tour. The free skin cancer screening tour ... New York City,s Grand Central Terminal, and will visit ...
Cached Medicine News:Health News:Advanced Analytical Reveals New Platform for Rapid Genotypic Identification of Microorganisms at ASM 2009 2Health News:Federal District Judge Dismisses Antitrust Lawsuit Against Batesville Casket Company 2Health News:Noblis Insights Panel Finds Growing Interest in Hospital Affiliation as a Strategic Response to Challenging Market Conditions 2Health News:Noblis Insights Panel Finds Growing Interest in Hospital Affiliation as a Strategic Response to Challenging Market Conditions 3Health News:Stopgap DNA repair needs a second step 2Health News:AVEENO(R) Announces Kick-Off of The Skin Cancer Foundation's 2nd Annual 'Road to Healthy Skin' Tour Presented by AVEENO(R) and Rite Aid 2Health News:AVEENO(R) Announces Kick-Off of The Skin Cancer Foundation's 2nd Annual 'Road to Healthy Skin' Tour Presented by AVEENO(R) and Rite Aid 3Health News:AVEENO(R) Announces Kick-Off of The Skin Cancer Foundation's 2nd Annual 'Road to Healthy Skin' Tour Presented by AVEENO(R) and Rite Aid 4
(Date:12/24/2014)... , Dec. 23, 2014 Echo Therapeutics, ... device company focused on skin permeation, continuous glucose ... Scott W. Hollander has been appointed Chief ... has more than 20 years of experience in ... and most recently served as Vice President, Business ...
(Date:12/24/2014)... 2014   Synageva BioPharma Corp. (NASDAQ: ... therapeutic products for rare disorders, today announced validation ... Marketing Authorization Application (MAA) for sebelipase alfa for ... request for accelerated assessment, which has the potential ... The MAA, and the Biologics License ...
(Date:12/24/2014)... , Dec. 23, 2014 Tianyin Pharmaceutical ... that specializes in patented biopharmaceutical, modernized traditional Chinese ... (API) today announced that the Company achieved the ... Manufacturing Practice (GMP) certificate of TPI,s Qionglai Facility ... (CFDA). The public notice period is a significant ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... May 25 Two late-breaking clinical trials presented ... clinical data supporting Abbott,s market-leading XIENCE V® Everolimus Eluting ... of more than 5,000 real-world, complex patients, XIENCE V ... at one year (0.84 percent per Academic Research Consortium ...
... 24 At a town hall meeting a year ago, President Obama ... by keeping older people out of more expensive institutional care.  "I actually think ... it helps keep people in their homes," the president told his audience in ... , , ...
Cached Medicine Technology:New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent 2New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent 3New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent 4New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent 5Medicare Policies Ignore Aging-at-Home Concept 2Medicare Policies Ignore Aging-at-Home Concept 3Medicare Policies Ignore Aging-at-Home Concept 4Medicare Policies Ignore Aging-at-Home Concept 5
CCR Medical conventional laryngoscope handles....
... Wire-Reinforced LMA ™ Airway., ,The ... tube which allows it to be ... while maintaining a good seal. This ... and dental surgery, or other procedures ...
... Airway. , ,Developed for cardiopulmonary resuscitation ... the LMA Fastrach™ has been designed to ... or neck. The LMA Fastrach™ allows continuous ... by emergency teams worldwide including NASA for ...
... in the production of airway ... an integrated solution to all ... single-use Portex Soft Seal Laryngeal ... to this wide portfolio of ...
Medicine Products: