Navigation Links
A*STAR scientists discover 'switch' critical to wound healing
Date:3/8/2013

etes. Chronic wounds also tend to affect the elderly and disabled patients, especially those confined to a wheelchair or bed-bound. Unfortunately, chronic wounds are currently poorly understood and insufficiently treated.

6. Dr. Prabha Sampath , principal investigator at IMB and lead author of the paper, said, "Our research provides a comprehensive understanding of the mechanism of the wound healing process. Moving forward, we hope to translate this research into improved patient outcomes. We can now build on this research, to see how we can modulate the defective switch in chronic wounds by targeting miR-198 and its interacting molecules, to develop new strategies for treating chronic wounds."

7. Professor Birgitte Lane, Executive Director of IMB, said, "This switch appears to be an entirely new regulatory component in wound healing, and probably a very important one. Poor wound healing is a major healthcare burden, and this discovery is particularly timely in the face of aging populations and the sharp global rise in diabetes. The finding gives us a platform from which to develop therapies that could significantly reduce chronic wounds and improve healthcare."

An FSTL1-miR-198 molecular 'see-saw' switch.

8. The information necessary to express microRNA-198 (miR-198) and follistatin-like 1 (FSTL1) protein are found in a single "message" produced by the cell. However, miR-198 and FSTL1 protein cannot be produced at the same time it can only be one or the other. These two molecules also have opposite roles: miR-198 (found in unwounded skin) inhibits skin cell migration and wound healing, whereas FSTL1 protein (expressed after injury) promotes skin cell migration and wound healing. A regulatory switch dictates their expression, and hence controls the "see-saw" between inactive resting skin cells and the cell migration necessary for wound healing.

9. Dr. Sampath and her team showed that healthy unwounded skin cont
'/>"/>

Contact: Ong Siok Ming (Ms)
ong_siok_ming@a-star.edu.sg
656-826-6254
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
2. Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
3. A*STAR scientists identify potential drug target for inflammatory diseases including cancers
4. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
5. Scientists solving the mystery of human consciousness
6. Scientists uncover multiple faces of deadly breast cancer
7. Scientists identify major source of cells defense against oxidative stress
8. Scientists tailor cell surface targeting system to hit organelle ZIP codes
9. Scientists rewrite rulebook on breast cancer in landmark global study
10. Warwick scientists uncover how checkpoint proteins bind chromosomes
11. NIH scientists link quickly spreading gene to Asian MRSA epidemic
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A*STAR scientists discover 'switch' critical to wound healing
(Date:9/30/2014)... 2014 FDA-approved injectable dermal fillers ... are used in several procedures that are performed ... but are primarily used for wrinkle treatment of ... these fillers are being used as popular treatments ... skin in the hands. (1) (2) Dr. Cynthia ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Healthpointe is ... now performing advanced foot and ankle reconstruction surgeries to ... orthopedic surgeon, Dr. Cortés specializes in the diagnosis and ... injuries . She is also trained to perform advanced ... orthopedic needs. Dr. Cortés is also fluent in Spanish. ...
(Date:9/30/2014)... To mark National Sickle Cell Month which ... with a Disability magazine has published an important ... disabling conditions. , As the new article ... establish a disability related to a hematological disorder, such ... defects, polycythemia vera, and aplastic anemias with bone marrow ...
(Date:9/30/2014)... Jiwa Law Corporation, a personal injury law firm ... be offering free consultation for personal injury claims of their ... for the first time to meet the Vancouver ICBC lawyers ... to understand what their rights are. The experts at Jiwa ... explain to them what the law firm can do regarding ...
(Date:9/30/2014)... Fresno, CA (PRWEB) September 30, 2014 ... announce the grand opening of its newest practice, located ... practice offers digital x-rays, general dentistry services , ... oral surgery. In addition to providing affordable and convenient ... same-day emergency dental appointments . Call Coast Dental ...
Breaking Medicine News(10 mins):Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 2Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 3Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 4Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 2Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 3Health News:Living with a Disability Magazine Marks National Sickle Cell Health Month with New Article on Hematological Disorders 2Health News:Living with a Disability Magazine Marks National Sickle Cell Health Month with New Article on Hematological Disorders 3Health News:Jiwa Law Corporation Now Offers Personal Injury Consultation Without Any Charge 2Health News:Coast Dental Clovis Celebrates Grand Opening 2Health News:Coast Dental Clovis Celebrates Grand Opening 3
... to promote healthcare in the two countries and this can ... Chinese Embassy said here Saturday.// ,"Healthcare is an important ... must join hands in this field. A doctors' exchange programme ... Cao Jiangru, first secretary, science and technology of the embassy ...
... individual responds to stress may be more relevant to ... in the fields of neurobiology and psychoneuroendocrinology. // Healthy ... a very healthy lifestyle. ,From a ... brain, psychologist Bruce McEwen, PhD, of the Laboratory of ...
... efficiently stop HIV virus from entering and infecting blood ... Florida. // Advancement has made man to stop producing ... ,HIV-1 has a technique to escape the antiviral ... getting mutated. But a research team led by Associate ...
... novel imaging study has indicated the potency of just a ... cravings to continue smoking. // ,Researchers found that the amount ... filling nearly 30% of the brain’s nicotine receptors and 3 ... experiences the high of smoking when all the receptors are ...
... Information is all set to release a new CD-ROM collects ... ,The Center for HIV Information at the University of California, ... CD-ROM that contain more than 40 selected chapters from the ... comprehensive, in-depth HIV information that is widely respected as one ...
... journal Nature Clinical Practice Endocrinology and Metabolism, scientists ... low fat western diet to be responsible for ... at the Children's Hospital of the University of ... food environment has become highly insulinogenic, as demonstrated ...
Cached Medicine News:Health News:India and China Agrees to Promote Healthcare Jointly 2Health News:Studying the psycho neurobiology of aging 2Health News:Studying the psycho neurobiology of aging 3Health News:A Protein from Primate may Save Humans from HIV ! 2Health News:A Protein from Primate may Save Humans from HIV ! 3Health News:Imaging study affords renewed thrust on smoking cessation treatments 2Health News:Imaging study affords renewed thrust on smoking cessation treatments 3Health News:A Comprehensive CD-ROM On HIV/AIDS Released By Center for HIV Information 2
(Date:9/30/2014)... 30, 2014 Passport Health, one of the ... has launched FluFree.com, a website designed to promote, educate ... For 20 years, Passport Health has provided its clients ... launch of FluFree.com is designed to address the growing ... of people who actually chose to get vaccinated. ...
(Date:9/30/2014)... , 30. September 2014 ... http://photos.prnewswire.com/prnh/20130430/LA01948LOGO Acutus ... ein minimal-invasives 3D-Herzkammer-Bildgebungs- und Dipoldichte-Mappingsystem in ... die zu komplexen Herzrhythmusstörungen einschließlich Vorhofflimmern ... Abschluss einer zusätzlichen Finanzierung über 26,2 ...
(Date:9/30/2014)... Sept. 30, 2014  Arena Solutions, the pioneer ... announced its Fall 2014 release, which includes two ... Arena DataExtract – and significant enhancements ... products are focused specifically on speeding time to ... of a complete history of tribal knowledge throughout ...
Breaking Medicine Technology:Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 2Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 3Acutus Medical, Inc. schließt zusätzliche Finanzierungsrunde Serie B über 26,2 Mio. USD ab, um Portfolio-Erweiterung zu finanzieren 2Acutus Medical, Inc. schließt zusätzliche Finanzierungsrunde Serie B über 26,2 Mio. USD ab, um Portfolio-Erweiterung zu finanzieren 3Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 2Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 3Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 4
... Corporation , the leading provider of real-time location ... its vice president - government business development, Chris Doran ... 2:45 p.m., June 1 at the VHA Real ... company also will demonstrate its RTLS solutions at Booth ...
... (Nasdaq: OPTR ) today announced that the Company ... June 8, 2011 at 11:00 a.m. Eastern Time at The ... http://photos.prnewswire.com/prnh/20090413/LA97352LOGO ) A live audio webcast of this ... Company,s website at www.optimerpharma.com . Replays of this presentation ...
Cached Medicine Technology:Awarepoint Vice President - Government Business Development Chris Doran to Speak at VHA Real Time Location Systems Conference 2011 2Optimer Pharmaceuticals to Present at the Jefferies 2011 Global Healthcare Conference 2
... is the first hand-held urine analyzer ... lab bench space. Automation of urine ... results between operators and transcription errors.Other ... corrects for ambient temperature and urine ...
... Ultra device consists of a non-compliant balloon ... mounted longitudinally on its outer surface. When ... the atherotomes score the plaque, creating initiation ... to as Atherotomy, allows dilatation of the ...
... catheters provide a simple, efficient and ... in the heart or cardiovascular system. ... ideal for high fidelity pressure measurement. ... 2 to 7 French and in ...
... catheters provide a simple, efficient and ... in the heart or cardiovascular system. ... ideal for high fidelity pressure measurement. ... 2 to 7 French and in ...
Medicine Products: