Navigation Links
A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
Date:4/2/2012

An international research team led by scientists from Singapore Immunology Network (SIgN) under the Agency of Science, Technology and Research (A*STAR) discovered that a special class of fatty molecules is essential for activating a unique group of early-responding immune cells. This study sheds light on how recognition of fatty molecules by immune cells could protect from infection, allergic reactions, autoimmune diseases and cancer. More importantly, it offers new opportunities to exploit the use of these stimulatory fatty molecules in therapeutic interventions, such as the development of new vaccines and drugs targetted for autoimmune diseases.

The early-responding immune cells investigated in this study, called the invariant natural killer T (iNKT) cells, are important as first line of defence against infectious and foreign agents. When stimulated, iNKT cells secrete large amounts of biological chemicals, and are capable of influencing the responses of other immune cells in the body.

It is well established that iNKT cells recognise and are activated by fatty molecules from various sources, including those from diseases-causing bacteria and those that are naturally produced in the thymus [1]. This study identifies for the first time, the actual type of fatty molecules that stimulates the development of iNKT cells in the thymus. This discovery came about through systematic biochemical and structural analysis of fatty molecules extracted from the thymus.

The team, co-led by Professor Gennaro De Libero and Dr Lucia Mori, Senior Principal Investigators at SIgN, found that the fatty molecules produced in the thymus which were able to stimulate iNKT cells all have the chemical linkage called ether bonds.

To validate the stimulatory activity of these special class of self-generated fatty molecules, the scientists artificially manufactured ether-bonded fatty molecules through synthetic chemistry, and found that they were sim
'/>"/>

Contact: Dr. Sarah Chang
chang_kai_chen@a-star.edu.sg
65-682-66442
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A*STAR scientist receives international award for innovation in healthcare technology
2. A*STAR and Institut Merieux/bioMerieux invest S$3m ($2.2m) in tuberculosis research
3. NTU and A*STAR launch joint Ph.D. research program in immunology
4. A*STAR scientists make headway for cancer treatment and cancer prevention with landmark discovery
5. Scientists Pinpoint Area of Brain That Fears Losing Money
6. Scientists Discover How HIV Is Transmitted Between Men
7. Prevention Is Key Research Goal for Premature Babies, Scientists Say
8. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
9. Scientists find donut-shaped structure of enzyme involved in energy metabolism
10. Neuroscientists reveal new links that regulate brain electrical activity
11. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... RI (PRWEB) December 17, 2014 ... recognize private practices that have made outstanding and ... in support and progression of private practice physical ... American Physical Therapy Association. , On behalf of ... OCS, owner and CEO of Performance accepted the ...
(Date:12/17/2014)... Hill, IL (PRWEB) December 17, 2014 ... 2015 Awards celebrate the best of the best in ... The award is only given to communities and agencies ... through the SeniorAdvisor.com site. Of the nearly 100,000 providers ... this award. Winners of the SeniorAdvisor.com Best of 2015 ...
(Date:12/17/2014)... get more fruits and vegetables at school than they do ... is true for students from wealthier families. These findings ... a healthy boost to poor students, diets, according to the ... students all ate a similar amount of fruits and vegetables ... recently in the journal Preventive Medicine . ...
(Date:12/15/2014)... Grants Pass, OR (PRWEB) December 15, 2014 ... factors perceived by United States women as impacting skin ... – the “Four C’s of skin care.” Water and ... the conclusions in a recent article describing the survey ... her experience, every item in every category discussed would ...
(Date:12/15/2014)... December 15, 2014 SIMpalm, a leading ... Connect App” for iPhone for its client, which allows ... is a company, specialized in finding the right wine. ... engine that uses combined sensory, chemistry and wine information. ... a virtual “wine fingerprint.” Those wines that are close ...
Breaking Medicine News(10 mins):Health News:Performance Physical Therapy Awarded with Jayne L. Snyder Private Practice of the Year 2014 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 3Health News:Poor Students Eat Healthier Foods at School, Study Finds 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2
... 31 HEI, Inc. (Nasdaq: HEII ),( ... into an agreement,to sell substantially all of the ... Inc., a wholly-owned subsidiary of Dutch based Smartrac ... substantially all the assets of,the RFID division, including ...
... /PRNewswire-FirstCall/ - MDS Inc. (TSX: MDS; NYSE:,MDZ), a ... global life,sciences markets, announced today that Stephen P. ... at the Thomas Weisel Partners,Healthcare Conference in Boston ... Time. Interested parties may access the live ...
... ARNA ) announced today that the company is ... Conference on September,6, 2007 at 10:00 a.m. Eastern Time ... New York City. Jack Lief, Arena,s President,and Chief Executive ... company and its clinical development and discovery programs. ...
... Aug. 31 World Heart,Corporation (WorldHeart) (Nasdaq: ... support systems, today announced the appointment of,Mr. David ... Officer.,Mr. Richard Juelis, the departing CFO, will provide ... assist with the transition and with certain,specific projects. ...
... way toward screening people at risk for lung cancer ... from the University of Colorado say. , The most ... said researcher Wilbur A. Franklin, M.D., Professor of Pathology ... goal would be to develop screening techniques for lung ...
... reopen around the country, a new study finds that parents ... early as fourth grade. ,A review of national and statewide ... typical 4th graders, 10% have already had more than a ... the past year. While the numbers are small in the ...
Cached Medicine News:Health News:HEI, Inc. Announces Sale of RFID Division Assets 2Health News:Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 2Health News:Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 3Health News:WorldHeart Appoints David Pellone Chief Financial Officer 2Health News:New technique detects specific chromosomal damage, may indicate lung cancer risk 2Health News:Underage drinking starts before adolescence 2Health News:Underage drinking starts before adolescence 3
(Date:12/15/2014)... -- The Government of Ghana has endorsed a ... and Terumo BCT to respond to the emerging Ebola crisis within ... health system capacity to the citizens of Ghana ... Readiness and Resilience Initiative (GERRI) is a multi-agency effort designed to: ... possible arrival of the Ebola epidemic , Provide new blood ...
(Date:12/13/2014)... 2014 Research and Markets ( ... "Drug Injection Devices to 2020" report ... http://photos.prnewswire.com/prnh/20130307/600769 As new drugs become ... of health conditions, drug developers have increasingly pursued ... process and increase the efficiency and reliability with ...
(Date:12/13/2014)... HUNTSVILLE, Ala. , Dec. 12, 2014 /PRNewswire-USNewswire/ ... has purchased the HiSeq X Ten sequencing system ... will enable HudsonAlpha to produce and analyze genomic ... purchase stems from the Institute,s commitment to research ... The HiSeq X Ten provides unprecedented capacity, ...
Breaking Medicine Technology:Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 2Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 3Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 4Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 5Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 6Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 2HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 3
... For the first time, the Integrated ... analytical, and post-analytical solution coupled with ... five major steps a sample undergoes ... between each one - it delivers ...
... four convenient formats to meet all clinical ... draping for any surgical procedure. All blankets ... up. , ,The precision, die-cut holes provide ... is soft against the patient's skin. Paediatric ...
... a more efficient way to control ... battery operated patient warming system, provides ... with a compact and better way ... surgical process. Its unique design combines ...
For use with WarmTouch® Warming Blankets for the prevention or treatment of hypothermia...
Medicine Products: