Navigation Links
A*STAR partners Roche to develop new cancer therapeutics
Date:7/14/2014

SingaporeA*STAR's Bioprocessing Technology Institute (BTI) has entered into an agreement with one of the world's largest pharmaceutical company, Roche, to identify novel drug candidates for the detection and treatment of cancer. The partnership brings together BTI's capabilities in novel antibody discovery and Roche's expertise in developing monoclonal antibody (mAbs) therapeutics, opening up the possibility of improved treatment for cancer, a leading cause of death worldwide.

The collaboration makes use of BTI's discovery of a new mechanism where antibodies can directly target and destroy cancer cells, which has the potential for an entirely new class of cancer treatment. Cancer cells may be distinguished from normal cells by their elevated levels of sugar on the cell surface. The mAbs discovered and generated by BTI are able to recognise these sugar targets and allow more accurate identification of cancer cells as compared to traditional antibodies that only target proteins. mAbs generated by BTI are also unique in having a novel mechanism of action; they cause pores to form on the surface of cancer cells, leading to cell degradation and the eventual death of these diseased cells.

Dr Andre Choo, Principal Scientist at BTI and lead investigator for the project, said, "It is exciting to be able to generate a new class of mAbs that can specifically recognise sugars and lead to rapid death of diseased cells. This opens up new strategies to target and kill cancer cells."

Based on this discovery, scientists from BTI have developed a pipeline of mAbs for major cancers found in Singapore. The partnership with Roche will allow new diagnostic tests and cancer treatments to be developed more quickly and to be brought earlier to patient care. Such treatments could complement and augment existing cancer drugs and result in more effective and safer treatments for cancer patients.

Prof Lam Kong Peng, Executive Director of BTI, said, "This collaboration underscores the effectiveness of BTI's antibody research and allows us to leverage on Roche's expertise to develop novel antibody-based therapeutics. We are confident that this will be the start of a long and fruitful partnership that will not only benefit human health but also the biologics industry."

Dr. Juan-Carlos Lopez, Head of the Roche Pharma Research and Early Development Academic Relations and Collaborations, said: "Accessing external innovation through partnerships with public sector research institutes is crucial for identifying first-in-class or best-in-class opportunities. Bringing together the know-how of BTI and the expertise of Roche increases the chance of success in developing novel antibody-based therapeutics targeting both cancer and cancer stem cells which have the potential to revolutionize how we treat cancer."


'/>"/>

Contact: Vanessa Loh
vanessa_loh@a-star.edu.sg
Biomedical Sciences Institutes (BMSI)
Source:Eurekalert  

Related medicine news :

1. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
2. Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
3. A*STAR scientists identify potential drug target for inflammatory diseases including cancers
4. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
5. A*STAR scientists discover switch critical to wound healing
6. A*STAR scientist Alex Matter awarded prestigious Szent-Györgyi Prize for progress in cancer
7. A*STAR scientist wins European Molecular Biology Organization Young Investigator award
8. A*STAR scientists uncover potential drug target to nip cancer in the bud
9. A*STAR scientists bring to light mechanism of drug for infections
10. Women With Older Partners More Often Admitted to Nursing Homes
11. University of Houston Graduate College of Social Work announces partnership with MD Anderson
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A*STAR partners Roche to develop new cancer therapeutics
(Date:2/20/2017)... ... ... Johns Hopkins All Children's Hospital celebrated a major milestone with the topping ... the halfway point of construction and lifting of the final beam on the top ... center for innovation aimed at finding new discoveries and treatments for childhood diseases. The ...
(Date:2/19/2017)... ... February 19, 2017 , ... The Citadel’s new ... students, is being led by Amelia Joseph, Ph.D. Joseph was engaged by the college ... the nursing department in early 2016. After a nation-wide search, she was selected to ...
(Date:2/19/2017)... ... 19, 2017 , ... Orbita, Inc., a leading ... Healthwise ® at HIMSS 2017 to showcase a breakthrough in ... education, technology and services, will demonstrate a voice-powered knowedge assistant based on ...
(Date:2/18/2017)... , ... February 17, 2017 , ... ... drvallecillos.com , Beverly Hills plastic surgeon Dr. Glenn Vallecillos ... , Dr. Vallecillos says, "Traditionally, plastic surgery has been centered around that idea ...
(Date:2/17/2017)... ... 2017 , ... Smiles by Seese is a comprehensive family dental practice ... leads the practice as a skilled and highly credentialed dentist who is qualified to ... patients of all ages with excellence in general, restorative, and cosmetic dentistry . ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... 2017 Adequate intake of vitamin ... minerals in one,s body. Consumers are well aware of ... a healthy composition of bones and teeth. Consumption of ... growing in the world. Medical research and clinical trials ... for treatment of prevalent disorders such as multiple sclerosis, ...
(Date:2/19/2017)...   AC Group Inc. , a leading company, ... in the PMS/EHR healthcare marketplace, will exhibit the 7 ... succeed in this ecosystem at HIMSS,17. ... from over 200 ACOs, compared and analyzed an ACO,s ... that are providing different pieces of Population Health technologies ...
(Date:2/19/2017)... , February 18, 2017 Marapharm ... to purchase a Medical Delivery Service with the specific ... transactions between qualified patients and caregivers. The delivery service ... located in the Coachella Valley, California ... Los Angeles area to the West, population ...
Breaking Medicine Technology: