Navigation Links
A Protein Links Alzheimer's, Down Syndrome
Date:5/20/2010

Amyloid-beta accumulates in eyes of Down-affected patients, spurring cataracts, study finds

THURSDAY, May 20 (HealthDay News) -- Researchers say a kind of protein that clogs the brain in Alzheimer's disease also accumulates in the eyes of Down syndrome patients and causes cataracts.

The finding is leading the researchers to develop an eye test for early signs of Alzheimer's in both disorders.

"People with Down syndrome develop symptoms of Alzheimer's-type dementia often by the age of 30," said study co-author Dr. Lee E. Goldstein, associate professor at Boston University School of Medicine, in a statement. "This is because they have an extra copy of a key Alzheimer's gene that leads to increased amyloid-beta accumulation in the brain. We discovered that this same protein starts to accumulate very early in the lens of the eye, even in children."

"The results are striking," added Dr. David G. Hunter, ophthalmologist-in-chief at Children's Hospital Boston and vice chairman of the department of ophthalmology at Harvard Medical School. "We have known that these cataracts are prevalent in people with Down syndrome and are sometimes seen at birth, but we never knew how they were related to the disorder. Now we know. These distinctive cataracts appear only in people with advanced Alzheimer's disease and much earlier in Down syndrome."

Goldstein said the team is developing an eye scanner to measure amyloid-beta, the protein in question, in the lens. "This approach may provide a way for early detection and monitoring of related pathology in the brain. Effective treatments for the brain disease in Down syndrome and Alzheimer's disease are on the horizon, and early detection is the key for successful intervention."

The findings were reported in the May 20 issue of the journal PLoS One and presented at the recent meeting of the Association for Research in Vision and Ophthalmology in Fort Lauderdale.

More information

For more about Alzheimer's disease, see the U.S. National Library of Medicine.



-- Randy Dotinga



SOURCE: BMC, news release, May 20, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists find protein spurs spread of prostate cancer
2. System that predicts protein structures could help researchers design drugs
3. Without this protein, embryonic development halts
4. Study finds key protein controls T-cell proliferation
5. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
6. The effect of dietary supplements, acids and animal protein on gastrointestinal disorders
7. A single protein regulates 2 immune pathways
8. Alzheimers memory problems originate with protein clumps floating in the brain, not amyloid plaques
9. Biosensor chip enables high-sensitivity protein analysis for disease diagnosis
10. Protein plays a critical role in the development of aggressive breast cancer
11. Structure of inner-ear protein is key to both hearing and inherited deafness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... December 04, 2016 , ... Are You Concerned About Mold In Your Home ... Indoor Air Quality Companies in VA, MD and DC, recently completed its application for ... new mold law in the district of Columbia is a good thing stated John ...
(Date:12/2/2016)... Calif. (PRWEB) , ... December 02, 2016 , ... On ... at the Hard Rock Hotel San Diego honoring the 2016 MPN Heroes—eight individuals who ... neoplasms (MPNs) by going above and beyond the standard of care, demonstrating leadership within ...
(Date:12/2/2016)... Portland, Maine (PRWEB) , ... December 02, 2016 , ... ... support group for caregivers of those affected by autism spectrum disorder (ASD) and other ... and Easter Seals Maine, will give parents and other caregivers the opportunity to share ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Hills, California, will be included in the 2016 “Guide to America’s Top Plastic ... based on the amalgamation of their education, experience, and professional associations. , ...
(Date:12/2/2016)... ... 02, 2016 , ... Universal Medical Systems, Inc. (UMS) the ... company to offer robotic imaging to veterinary medicine is sponsoring the appearance of ... the American Association of Equine Practitioners 62nd Annual Convention from December 4-6, 2016 ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2, 2016  Eli Lilly and Company (NYSE: ... 2017 and provide updated financial guidance for 2016 on ... conference call on that day with the investment community ... The conference call will begin at 10 ... access a live webcast of the conference call through ...
(Date:12/2/2016)... 2, 2016 CVS Health Corporation (NYSE: ... in New York City on Thursday, December 15, 2016, beginning at 8:00 a.m. ... will provide an in-depth review of the company,s strategies ... company will also discuss 2017 earnings guidance during the ... the event will be broadcast simultaneously on the Investor ...
(Date:12/2/2016)... , Dec. 2, 2016 Lianluo Smart ... or "the Company") which develops, markets and sells ... China and international markets, ... Diagnosis and Treatment New Progress Forum, co-hosted by ... Guangdong Province , Guangdong Provincial People,s Hospital ...
Breaking Medicine Technology: